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Terapia com Peptídeos na Medicina Musculoesquelética

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Injectable and regenerative peptide therapies in orthopaedics and sports medicine — what the evidence shows for tendon, cartilage and bone healing, and where the hype outpaces the data.

Updated Aug 2026
Uma cadeia molecular de peptídeos ao lado de um pequeno frasco.
As terapias com peptídeos são amplamente comercializadas para cicatrização e recuperação; as evidências para uso musculoesquelético são limitadas. Kieran Hirpara 4.0

Esta página foi traduzida automaticamente e ainda não foi verificada por um médico. A versão em inglês é a versão oficial.

O que você está sentindo

Você provavelmente está lidando com dor e rigidez nos seus tecidos moles. Esse desconforto pode parecer profundo no músculo ou ao longo dos tendões. Frequentemente, ele se intensifica após um dia de atividades. Você pode notar que é pior quando acorda pela primeira vez pela manhã. A rigidez pode aliviar um pouco à medida que você se move, mas pode retornar se você se esforçar demais.

Tarefas diárias simples podem se tornar difíceis. Você pode ter dificuldade em alcançar as costas para fechar um sutiã. Enfiar a camisa pode puxar a área dolorida. Dormir do lado afetado pode mantê-lo acordado. Esses pequenos movimentos podem desencadear dores agudas ou uma dor surda que persiste. Seu cirurgião entende como esses limites afetam sua rotina.

Embora alguns tratamentos mostrem promessa em estudos com animais, as evidências sobre terapias com peptídeos injetáveis em humanos atualmente são insuficientes. Não há ensaios clínicos randomizados investigando o uso de BPC-157 em sujeitos humanos. A ciência ainda não é forte o suficiente para determinar sua eficácia geral ou segurança para aprimoramento esportivo. Por essa razão, seu cirurgião não recomenda o uso de BPC-157 para desempenho e recuperação esportiva.

Alguns pacientes encontram alívio com outras abordagens. Por exemplo, o EGYFIL mostrou-se seguro para tratar dor e rigidez nos tecidos moles. Parece reduzir a dor e a rigidez durante os três dias de tratamento. Você pode sentir esse alívio tão cedo quanto três horas após a primeira aplicação. No entanto, os resultados variam, e seu cirurgião o ajudará a escolher o caminho mais seguro a seguir.

É importante ouvir o seu corpo. Se uma atividade causar dor aguda, pare e descanse. Aplique gelo ou calor conforme orientado pela sua equipe de cuidados. Mantenha um registro de quando a dor é pior. Isso ajuda seu cirurgião a personalizar seu plano de tratamento. Lembre-se, a cura leva tempo. Seja paciente com seu progresso e comunique-se abertamente com sua equipe médica sobre o que você está sentindo.

O que está realmente acontecendo

O seu corpo depende de um equilíbrio delicado para manter as articulações em movimento suave. A cartilagem atua como um revestimento liso nas extremidades dos ossos, enquanto os tendões funcionam como cordas resistentes que conectam o músculo ao osso. Quando você lesiona essas estruturas, o processo natural de reparo frequentemente é insuficiente. Por exemplo, quando um tendão se rompe, a conexão entre o tendão e o osso pode não cicatrizar com a força ou a estrutura necessárias. Isso leva à instabilidade e à dor, pois o ponto de fixação fica comprometido.

Em alguns casos, a própria superfície articular se desgasta ou desenvolve defeitos. Isso pode ocorrer após uma lesão ou devido ao estresse de longo prazo. A superfície lisa torna-se áspera, causando fricção e desconforto durante o movimento. O seu corpo tenta corrigir esses problemas enviando células para a área, mas, às vezes, o tecido de reparo é fraco ou não se integra bem ao tecido saudável circundante. É por isso que o simples repouso ou os tratamentos básicos podem não resolver completamente o problema.

Os pesquisadores estão explorando novas maneiras de apoiar esse processo de cicatrização. Algumas abordagens utilizam peptídeos especiais — pequenos blocos de construção das proteínas — para estimular o seu corpo a se reparar de forma mais eficaz. Em estudos com animais, certos peptídeos demonstraram potencial para fortalecer as conexões entre tendão e osso e melhorar a cicatrização da cartilagem. Outros tratamentos visam reduzir a inflamação rapidamente, ajudando você a sentir menos dor e rigidez em questão de horas ou dias. No entanto, é importante saber que, para muitas dessas terapias mais recentes, como a BPC-157, atualmente não há evidências clínicas de ensaios em humanos que comprovem sua eficácia ou segurança para a recuperação esportiva. Seu cirurgião pode ajudá-lo a entender quais opções têm suporte sólido e quais ainda são experimentais.

O que esperar

Deve saber que as evidências atuais não apoiam o uso clínico rotineiro de muitas terapias injetáveis com peptídeos na ortopedia e na medicina desportiva. Para a maioria destes tratamentos, a base científica ainda é insuficiente. Isto significa que ainda não podemos confirmar a sua eficácia global, segurança ou as melhores formas de os utilizar para a cicatrização.

Alguns peptídeos específicos mostram potencial em estudos laboratoriais iniciais, mas estes resultados provêm de ratos, cavalos ou culturas de células, não de seres humanos. Por exemplo, certos peptídeos ajudaram na cicatrização tendinosa em modelos de rato e na reparação da cartilagem em modelos de cavalo. No entanto, não existem ensaios clínicos em humanos para o BPC-157. Devido a esta lacuna nos dados humanos, não recomendamos a utilização do BPC-157 para o desempenho ou recuperação desportiva. A ciência simplesmente não é robusta o suficiente para apoiar o seu uso em atletas.

Existem algumas exceções onde existem dados humanos. O EGYFIL é um desses tratamentos. Parece ser seguro para reduzir a dor e a rigidez nos tecidos moles. Pode notar uma redução dos sintomas tão cedo como três horas após a primeira aplicação. O curso do tratamento dura tipicamente três dias, durante os quais deve sentir menos dor e rigidez.

Para outras condições, como defeitos trocleares (um tipo de lesão da superfície articular), tratamentos como peptídeos autoensambláveis ou microfratura podem melhorar os sintomas em comparação com a não intervenção. No entanto, a melhoria provém de causas diferentes, dependendo do método utilizado.

Em geral, o seu prognóstico depende da terapia específica. Muitos tratamentos com peptídeos carecem de benefícios humanos comprovados. Outros, como o EGYFIL, oferecem alívio a curto prazo para a dor e a rigidez. O seu cirurgião irá ajudá-lo a compreender quais as opções que têm evidência real por trás delas e quais não têm. O nosso objetivo é ter expectativas realistas, não promessas. Se um tratamento carece de dados humanos robustos, seremos honestos sobre isso consigo.

Reviewed by Kieran Hirpara · 12 June 2026.

Want the clinical detail? Read the clinician version.

Talk to your treating clinician for advice specific to you.

For an appointment with the CQ Hand + Upper Limb team, ask your GP about a referral or visit www.cqupperlimb.com.

Evidence & references

This is the clinical evidence summary written for health professionals. It is technical, and it lists the research this page was built from. You do not need to read it to understand your treatment or to make a decision about it.

Overview

  • Orthopaedic and sports medicine providers must understand the current lack of evidence to support the clinical use of injectable peptide therapies, despite their potential therapeutic and regenerative benefits [1].
  • Therapeutic strategies for microfracture augmentation, such as those using growth factor–functionalized self-assembling peptide hydrogel scaffolds, can be cost-effective ways to improve cartilage healing outcomes [2].
  • Functionalized self-assembled peptides with hBMP7 biological activity promote the differentiation of adipose-derived stem cells (ADSCs) into nucleus pulposus-like cells [3].
  • Treatment of trochlear defects with only KLD (self-assembling peptide) or only microfracture resulted in an improvement in clinical symptoms compared with no treatment [4].
  • The improvement in clinical symptoms from treating defects with only KLD or only microfracture likely resulted from different causes depending on the treatment [4].
  • The literature on injuries involving artificial turf is suitable for qualitative analysis only due to vast heterogeneity in factors such as level of play, sex, and definition of injury [5].
  • The authors do not recommend the use of BPC-157 for sports performance and recovery because there are no randomized controlled trials investigating its use in human subjects [7].
  • The science is clearly lacking to determine the overall effectiveness, safety profile, and clinical indications for BPC-157 use in sports enhancement in athletes [7].
  • The critical reader uses figures in publications to guide the interpretation of study findings that are described in the text [8].
  • EGYFIL, a topical lotion based on hyaluronic acid and peptides, is safe and seems to reduce pain and stiffness in patients during the 3 days of treatment [9].
  • EGYFIL reduces pain and stiffness in patients already after 3 hours from the first application [9].

How It Works

  • Injectable peptide therapy possesses significant therapeutic and regenerative potential [1].
  • Orthopaedic and sports medicine providers currently lack sufficient evidence to support the clinical use of peptide therapies [1].
  • Self-assembling peptides with hBMP7 biological activity promote the differentiation of adipose-derived stem cells (ADSCs) into nucleus pulposus-like cells [3].
  • Treatment of trochlear defects with only KLD self-assembling peptide or only microfracture results in an improvement in clinical symptoms compared with no treatment [4].
  • The improvement in clinical symptoms from KLD or microfracture treatment likely results from different causes depending on the specific treatment [4].
  • There are no randomized controlled trials investigating the use of BPC-157 in human subjects [7].
  • The science is lacking to determine the overall effectiveness, safety profile, and clinical indications for BPC-157 use in sports enhancement in athletes [7].
  • The authors do not recommend the use of BPC-157 for sports performance and recovery [7].
  • EGYFIL, a topical lotion based on hyaluronic acid and peptides, is safe for the treatment of pain and stiffness in soft tissues [9].
  • EGYFIL reduces pain and stiffness in patients during a 3-day treatment period [9].
  • EGYFIL reduces pain and stiffness already after 3 hours from the first application [9].
  • BMP-7 application significantly enhances the quality of tendon-to-bone healing by promoting structural maturation [10].
  • BMP-7 application significantly enhances the quality of tendon-to-bone healing by promoting functional stability [10].
  • GHRP-2 administration reduced M1 macrophage polarization in a rat rotator cuff tear model [11].
  • GHRP-2 administration enhanced histologic tendon-bone healing properties in a rat rotator cuff tear model [11].
  • GHRP-2 administration enhanced biomechanical tendon-bone healing properties in a rat rotator cuff tear model [11].
  • Axon preservation and minimal inflammation were observed in animals treated with BDNF-incorporated biofunctionalized peptide-based hydrogel [12].
  • Locomotor functional recovery was not observed in animals treated with BDNF-incorporated biofunctionalized peptide-based hydrogel [12].
  • The designed intervention of BDNF-incorporated hydrogel indicates potentiality for further evaluations in developing efficient therapies for severe spinal cord injury [12].

What the Evidence Shows

  • Orthopaedic and sports medicine providers must understand the current lack of evidence to support the clinical use of injectable peptide therapies [1].
  • The improvement in clinical symptoms from KLD or microfracture alone likely resulted from different causes depending on the treatment [4].
  • Injectable therapeutic peptides are not recommended for sports performance and recovery because there are no randomized controlled trials investigating their use in human subjects [7].
  • The science is lacking to determine the overall effectiveness, safety profile, and clinical indications for peptide use in sports enhancement in athletes [7].
  • BMP-7 application significantly enhances the quality of tendon-to-bone healing by promoting structural maturation and functional stability in a rat rotator cuff tear model [10].
  • GHRP-2 administration enhanced histologic and biomechanical tendon-bone healing properties in a rat rotator cuff tear model [11].

Practical Considerations

  • The science is lacking to determine the overall effectiveness, safety profile, and clinical indications for BPC-157 in sports enhancement in athletes [7].
  • The use of BPC-157 for sports performance and recovery is not recommended [7].
  • Functionalized self-assembled peptides promote the differentiation of adipose-derived stem cells (ADSCs) into nucleus pulposus-like cells [3].
  • Treatment of trochlear defects with only KLD (self-assembling peptide) resulted in an improvement in clinical symptoms compared with no treatment [4].
  • Treatment of trochlear defects with only microfracture resulted in an improvement in clinical symptoms compared with no treatment [4].
  • The improvement in clinical symptoms from KLD or microfracture treatment likely resulted from different causes depending on the treatment [4].
  • EGYFIL reduces pain and stiffness in patients during the 3 days of treatment [9].

Key Evidence

  • [L5] While peptide therapy may possess significant therapeutic and regenerative potential, it is critical that orthopaedic and sports medicine providers understand the current lack of evidence to support the clinical use of these peptides. [1] (10.1177/03635465251357593)
  • [L5] Therapeutic strategies for microfracture augmentation, such as those presented in this study, can be cost-effective ways to improve cartilage healing outcomes. [2] (10.1177/03635465211021798)
  • [L5] The functionalized self-assembled peptide promotes the differentiation of ADSCs into nucleus pulposus-like cells. [3] (10.1186/s13018-022-03102-8)
  • [L5] Treatment of defects with only KLD or with only microfracture resulted in an improvement in clinical symptoms compared with no treatment; the improvement likely resulted from different causes depending on the treatment. [4] (10.2106/jbjs.m.01408)
  • [L4] The authors argue that the literature on injuries involving artificial turf is suitable for qualitative analysis only due to vast heterogeneity in factors such as level of play, sex, and definition of injury. [5] (10.1177/03635465231210186)
  • [L5] The authors do not recommend the use of BPC-157 for sports performance and recovery because there are no randomized controlled trials investigating its use in human subjects, and the science is clearly lacking to determine the overall effectiveness, safety profile, and clinical indications for sports enhancement in athletes. [7] (10.1016/j.arthro.2024.09.005)
  • [L5] The critical reader uses figures in publications to guide the interpretation of study findings that are described in the text. [8] (10.1177/03635465241259467)
  • [L4] EGYFIL is safe and seems to reduce pain and stiffness in patients during the 3 days of treatment, already after 3 h from the first application. [9] (10.1186/s12891-023-06903-y)
  • [L5] BMP-7 application significantly enhances the quality of tendon-to-bone healing by promoting structural maturation and functional stability. [10] (10.1016/j.jse.2026.04.003)
  • [L5] GHRP-2 administration reduced M1 macrophage polarization and enhanced histologic and biomechanical tendon-bone healing properties in a rat rotator cuff tear model. [11] (10.1016/j.arthro.2024.11.094)
  • [L5] Although locomotor functional recovery was not observed, axon preservation and minimal inflammation in animals treated with BDNF-incorporated hydrogel indicate the potentiality of the designed intervention for further evaluations in the path of developing efficient therapies for severe spinal cord injury. [12] (10.1016/j.injury.2018.12.027)

References

[1] Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. The American Journal of Sports Medicine. 2026. DOI: 10.1177/03635465251357593

[2] Microfracture Augmentation With Trypsin Pretreatment and Growth Factor–Functionalized Self-assembling Peptide Hydrogel Scaffold in an Equine Model. The American Journal of Sports Medicine. 2021. DOI: 10.1177/03635465211021798

[3] Self-assembling peptides with hBMP7 biological activity promote the differentiation of ADSCs into nucleus pulposus-like cells. Journal of Orthopaedic Surgery and Research. 2022. DOI: 10.1186/s13018-022-03102-8

[4] Effects of the Combination of Microfracture and Self-Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model. Journal of Bone and Joint Surgery. 2014. DOI: 10.2106/jbjs.m.01408

[5] Lower Extremity Injury Rates on Artificial Turf Versus Natural Grass Playing Surfaces: Response. The American Journal of Sports Medicine. 2024. DOI: 10.1177/03635465231210186

[7] Injectable Therapeutic Peptides—An Adjunct to Regenerative Medicine and Sports Performance?. Arthroscopy. 2024. DOI: 10.1016/j.arthro.2024.09.005

[8] The Critical Reader: Visualizing Data. The American Journal of Sports Medicine. 2024. DOI: 10.1177/03635465241259467

[9] A pre-market interventional, single-arm clinical investigation of a new topical lotion based on hyaluronic acid and peptides, EGYFILTM, for the treatment of pain and stiffness in soft tissues. BMC Musculoskeletal Disorders. 2023. DOI: 10.1186/s12891-023-06903-y

[10] Effects of BMP-7 and Low Molecular Weight Peptide Solution on Healing in a Rotator Cuff Tear Model: A Histopathological and Biomechanical Study in Rats. Journal of Shoulder and Elbow Surgery. 2026. DOI: 10.1016/j.jse.2026.04.003

[11] Growth Hormone–Releasing Peptide 2 May Be Associated With Decreased M1 Macrophage Production and Increased Histologic and Biomechanical Tendon‐Bone Healing Properties in a Rat Rotator Cuff Tear Model. Arthroscopy. 2024. DOI: 10.1016/j.arthro.2024.11.094

[12] Biofunctionalized peptide-based hydrogel as an injectable scaffold for BDNF delivery can improve regeneration after spinal cord injury. Injury. 2019. DOI: 10.1016/j.injury.2018.12.027

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b. Any arrangements, understandings, or agreements regarding the Licensed Material not stated herein are separate from and independent of the terms and conditions of this Public License.

Section 8 -- Interpretation.

a. For the avoidance of doubt, this Public License does not, and shall not be interpreted to, reduce, limit, restrict, or impose conditions on any use of the Licensed Material that could lawfully be made without permission under this Public License.

b. To the extent possible, if any provision of this Public License is deemed unenforceable, it shall be automatically reformed to the minimum extent necessary to make it enforceable. If the provision cannot be reformed, it shall be severed from this Public License without affecting the enforceability of the remaining terms and conditions.

c. No term or condition of this Public License will be waived and no failure to comply consented to unless expressly agreed to by the Licensor.

d. Nothing in this Public License constitutes or may be interpreted as a limitation upon, or waiver of, any privileges and immunities that apply to the Licensor or You, including from the legal processes of any jurisdiction or authority.

Creative Commons is not a party to its public licenses. Notwithstanding, Creative Commons may elect to apply one of its public licenses to material it publishes and in those instances will be considered the “Licensor.” The text of the Creative Commons public licenses is dedicated to the public domain under the CC0 Public Domain Dedication. Except for the limited purpose of indicating that material is shared under a Creative Commons public license or as otherwise permitted by the Creative Commons policies published at creativecommons.org/policies, Creative Commons does not authorize the use of the trademark "Creative Commons" or any other trademark or logo of Creative Commons without its prior written consent including, without limitation, in connection with any unauthorized modifications to any of its public licenses or any other arrangements, understandings, or agreements concerning use of licensed material. For the avoidance of doubt, this paragraph does not form part of the public licenses.

Creative Commons may be contacted at creativecommons.org.