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Anabolic Steroids, Testosterone and Tendon Rupture Risk
Anabolic steroids and testosterone are linked to a higher risk of tendon rupture, including the rotator cuff, biceps and quadriceps. How steroids and TRT affect tendons, joints, bone and recovery from surgery.
What you're feeling¶
You may notice pain in your shoulder that worsens with activity. This discomfort often flares up at night, making it hard to sleep on that side. You might find it difficult to reach behind your back to fasten a bra or tuck in a shirt. Simple tasks like lifting objects or raising your arm can become challenging.
Your surgeon will consider your hormonal status when assessing these symptoms. Low testosterone levels are linked to an increased risk of wear-and-tear arthritis in the joint. This condition can cause stiffness and pain as the cartilage breaks down. Maintaining optimal hormone levels may help protect your joint health, but deficiency can increase the risk of injury or re-injury.
If you have been prescribed testosterone, be aware that it is associated with a higher risk of rotator cuff tears. The rotator cuff is a group of muscles and tendons that stabilize your shoulder. You might experience sudden weakness or pain if a tear occurs. There is also an increased risk of needing subsequent repairs to fix these tears.
In some cases, testosterone use is linked to a higher risk of infection-related reoperations after total shoulder replacement. Total shoulder arthroplasty is a procedure where damaged joint surfaces are replaced with artificial parts. You may face a higher risk of any type of reoperation after this surgery. Further research is needed to understand exactly why testosterone increases the risk of needing another surgery after shoulder replacement.
If you are using anabolic steroids, your surgeon should discuss your endocrinologic history with you. Anabolic steroids are synthetic substances similar to the male sex hormone testosterone. Their use may contribute to pectoralis major rupture, which is a tear in the large chest muscle. This injury often causes sharp pain and bruising in the front of the shoulder.
While continuing anabolic steroids during recovery from a pectoralis major rupture does not seem to negatively affect functional recovery, caution is advised. Clinicians should prescribe testosterone replacement therapy judiciously. This means carefully weighing the benefits against the risks for your unique profile. Your surgeon will counsel you on these risks to help you make informed decisions about your care.
What's actually happening¶
Testosterone levels in your body act like a dimmer switch for joint and tendon health. There is a specific threshold where levels become too low or too high, and both extremes can weaken your tissues. When levels are suboptimal, the smooth coating on your bone ends—called cartilage—may wear down faster. This wear-and-tear arthritis reduces the cushioning in your joints, making them more prone to damage.
Your tendons are thick ropes of fibers that connect muscle to bone. In some cases, testosterone use is linked to a higher risk of these ropes tearing. For example, bodybuilders using anabolic steroids have seen more pectoralis major ruptures. Similarly, patients prescribed testosterone face an increased risk of rotator cuff tears in the shoulder. These tears happen because the tissue structure changes, making it less able to handle stress.
This risk extends to major surgeries like total shoulder replacement. Men using testosterone have a higher chance of needing a second surgery after their first shoulder replacement. This is often due to infections or other complications that prevent proper healing. Your surgeon needs to know your full hormone history because low testosterone can also increase the risk of osteoarthritis. Maintaining balanced levels is key to keeping your joints strong and stable.
While some short-term testosterone use before surgery might help with bone density and body composition, long-term or high-dose use carries risks. It can lead to reoperations or infections that complicate your recovery. Your surgeon will assess your unique risk profile before deciding on any hormone therapy. Understanding these connections helps you and your medical team protect your joints during treatment and recovery.
What to expect¶
Your surgeon will look at your hormonal health as part of your overall injury risk. Testosterone levels have a complex link to shoulder problems. Low testosterone is linked to a higher risk of wear-and-tear arthritis in the joint. Maintaining healthy levels may help keep your joints strong. However, using testosterone or anabolic steroids can also change how your tendons handle stress.
If you are prescribed testosterone, you may face a higher risk of tearing the rotator cuff tendons in your shoulder. This group of patients also sees more follow-up surgeries to repair these tears. If you use anabolic steroids, there is a specific risk of rupturing the large chest muscle. This is most common in body builders. If you have already suffered this chest muscle rupture, continuing steroid use does not seem to hurt your functional recovery.
For men undergoing shoulder replacement surgery, testosterone use is linked to higher risks. You may face a greater chance of infection-related reoperations. You may also face a higher risk of any type of reoperation after your primary shoulder replacement. Your surgeon will discuss your endocrinologic history with you. They will counsel you on the risks of injury or re-injury if you have testosterone deficiency.
If you need testosterone replacement therapy, it is prescribed with care. It is too early to say it directly causes knee ligament injuries like ACL tears. But your unique risk profile matters. Some studies show that giving testosterone around the time of surgery can improve your body composition and bone density. It may also improve your clinical outcomes after orthopaedic surgery.
Data on other risks, like stroke in young adults, remains limited. Your surgeon needs to weigh these benefits against the increased risk of tendon tears and reoperations. Be honest about your steroid or testosterone use. This helps your team plan the safest path for your recovery and long-term joint health.
Evidence & references
Overview¶
- Testosterone replacement therapy is associated with increased odds of surgically treated tendon rupture [1].
- Testosterone users had a 2.9-fold increased risk of tendon rupture compared to nonusers [2].
- It is premature to imply causation between testosterone replacement therapy and anterior cruciate ligament injuries based solely on existing results due to confounding variables [3].
- Clinicians should remain vigilant and prescribe testosterone replacement therapy judiciously with a thorough assessment of each patient's unique risk profile regarding anterior cruciate ligament injury risk [3].
- There is a threshold-dependent relationship between testosterone levels and shoulder pathology [4].
- Hormonal status should be considered in musculoskeletal risk assessment [4].
- The use of prescription testosterone is associated with an increased likelihood of experiencing a distal biceps tendon injury [5].
- The use of prescription testosterone is associated with an increased likelihood of subsequently requiring surgical repair for distal biceps tendon injury [5].
- Patients with prior prescription testosterone exposure have an increased rate of distal biceps tendon injury compared with patients without such exposure [5].
- Patients with prior prescription testosterone exposure have an increased rate of biceps tendon repair compared with patients without such exposure [5].
- Surgeons should be more intentional about discussing endocrinologic history with patients regarding quadriceps tendon injury risk [6].
- Surgeons should counsel patients with testosterone deficiency on the risks for injury or re-injury [6].
- Patients who filled a prescription for testosterone replacement therapy were much more likely to experience a quadriceps muscle or tendon injury within 1 year of filling their prescription [7].
- Patients who filled a prescription for testosterone replacement therapy were at increased risk of undergoing surgical repair of the quadriceps tendon [7].
- Testosterone replacement therapy is associated with increased tendon rupture risk in men [8].
- Testosterone replacement therapy is not associated with increased tendon rupture risk in women [8].
- The association between testosterone replacement therapy and increased tendon rupture risk may be due to sex-specific differences in dosing [8].
- Anabolic steroid use may contribute to pectoralis major rupture [9].
- Continuation of anabolic steroids during recovery from pectoralis major rupture does not seem to have a negative effect on functional recovery [9].
- Selective androgen receptor modulator (SARM) use is associated with tendon damage [10].
- Prescription testosterone is associated with a higher risk of infection-related reoperations after primary total shoulder arthroplasty in male patients [13].
- Prescription testosterone is associated with a higher risk of all-cause reoperations after primary total shoulder arthroplasty in male patients [13].
Background & Causes¶
- Testosterone replacement therapy is associated with increased odds of surgically treated tendon rupture [1].
- Testosterone users had a 2.9-fold increased risk of tendon rupture compared to nonusers [2].
- It is premature to imply causation between testosterone replacement therapy and anterior cruciate ligament injuries based solely on existing results due to confounding variables [3].
- There is a threshold-dependent relationship between testosterone levels and shoulder pathology [4].
- Prescription testosterone use is associated with an increased likelihood of experiencing a distal biceps tendon injury [5].
- Patients with prior prescription testosterone exposure have an increased rate of biceps tendon repair compared with patients without such exposure [5].
- Testosterone therapy is associated with increased odds of quadriceps tendon injury [6].
- Patients who filled a prescription for testosterone replacement therapy were much more likely to experience a quadriceps muscle or tendon injury within 1 year of filling their prescription [7].
- Patients who filled a prescription for testosterone replacement therapy were at increased risk of undergoing surgical repair of the quadriceps tendon [7].
- Testosterone replacement therapy is associated with increased tendon rupture risk in men but not women [8].
- The association between testosterone replacement therapy and increased tendon rupture risk in men but not women may be due to sex-specific differences in dosing [8].
- Anabolic steroid use may contribute to pectoralis major rupture [9].
- Continuation of anabolic steroids during recovery from pectoralis major rupture does not seem to have a negative effect on functional recovery [9].
- Selective androgen receptor modulator (SARM) use is associated with tendon damage [10].
- Testosterone replacement therapy within 1 year of rotator cuff repair appears to be a risk factor for multiple postoperative complications [11].
- Testosterone replacement therapy within 1 year of rotator cuff repair appears to be a risk factor for subsequent shoulder surgery [11].
- Further research is needed to understand the mechanism by which testosterone increases the risk of reoperation after total shoulder arthroplasty [12].
- Prescription testosterone is associated with an increased risk of infection-related reoperations after primary total shoulder arthroplasty in male patients [13].
- Prescription testosterone is associated with an increased risk of all-cause reoperations after primary total shoulder arthroplasty in male patients [13].
- Bioavailable testosterone levels are a risk factor for osteoarthritis [17].
- There is a causal relationship between bioavailable testosterone levels and osteoarthritis [17].
- Low testosterone levels are independently associated with an increased risk of osteoarthritis in the U.S. population [18].
Symptoms & Presentation¶
- Testosterone replacement therapy is associated with increased odds of surgically treated tendon rupture [1].
- Testosterone users had a 2.9-fold increased risk of tendon rupture compared to nonusers [2].
- It is premature to imply causation between testosterone replacement therapy and anterior cruciate ligament injuries based solely on existing results due to confounding variables [3].
- There is a threshold-dependent relationship between testosterone levels and shoulder pathology [4].
- Prescription testosterone use is associated with an increased likelihood of experiencing a distal biceps tendon injury [5].
- Patients with prior prescription testosterone exposure have an increased rate of biceps tendon repair compared with patients without such exposure [5].
- Testosterone therapy is associated with increased odds of quadriceps tendon injury [6].
- Patients who filled a prescription for testosterone replacement therapy were much more likely to experience a quadriceps muscle or tendon injury within 1 year of filling their prescription [7].
- Patients who filled a prescription for testosterone replacement therapy were at increased risk of undergoing surgical repair of the quadriceps tendon [7].
- Testosterone replacement therapy is associated with increased tendon rupture risk in men but not women [8].
- Anabolic steroid use may contribute to pectoralis major rupture [9].
- Selective androgen receptor modulator (SARM) use is associated with tendon damage [10].
- Testosterone replacement therapy within 1 year of rotator cuff repair appears to be a risk factor for multiple postoperative complications [11].
- Testosterone replacement therapy within 1 year of rotator cuff repair appears to be a risk factor for subsequent shoulder surgery [11].
- Supplemental testosterone increases the risk of reoperation after total shoulder arthroplasty [12].
- Prescription testosterone is associated with an increased risk of infection-related reoperations after primary total shoulder arthroplasty in male patients [13].
- Prescription testosterone is associated with an increased risk of all-cause reoperations after primary total shoulder arthroplasty in male patients [13].
- Testosterone therapy is associated with rotator cuff tears, repairs, and revision repairs [15].
- Testosterone deficiency is associated with poorer postoperative outcomes in total joint arthroplasty [16].
Management¶
- Testosterone replacement therapy is associated with increased odds of surgically treated tendon rupture [1].
- Testosterone users had a 2.9-fold increased risk of tendon rupture compared to nonusers [2].
- It is premature to imply causation between testosterone replacement therapy and ACL injuries based solely on existing results due to confounding variables [3].
- Clinicians should remain vigilant and prescribe TRT judiciously with a thorough assessment of each patient's unique risk profile [3].
- Findings suggest a threshold-dependent relationship between testosterone and shoulder pathology [4].
- Hormonal status should be considered in musculoskeletal risk assessment [4].
- The use of prescription testosterone is associated with an increased likelihood of experiencing a distal biceps tendon injury [5].
- The use of prescription testosterone is associated with an increased likelihood of subsequently requiring surgical repair for distal biceps tendon injury [5].
- Patients with prior prescription testosterone exposure have an increased rate of distal biceps tendon injury compared with patients without such exposure [5].
- Patients with prior prescription testosterone exposure have an increased rate of biceps tendon repair compared with patients without such exposure [5].
- Surgeons should be more intentional about discussing endocrinologic history with patients [6].
- Surgeons should counsel patients with testosterone deficiency on the risks for injury or re-injury [6].
- Patients who filled a prescription for testosterone replacement therapy were much more likely to experience a quadriceps muscle or tendon injury within 1 year of filling their prescription [7].
- Patients who filled a prescription for testosterone replacement therapy were at increased risk of undergoing surgical repair of the quadriceps tendon [7].
- TRT is associated with increased tendon rupture risk in men [8].
- TRT is not associated with increased tendon rupture risk in women [8].
- The association between TRT and tendon rupture risk in men but not women may be due to sex-specific differences in dosing [8].
- Anabolic steroids use may contribute to pectoralis major rupture injury [9].
- Continuation of anabolic steroids during recovery from pectoralis major rupture does not seem to have a negative effect on functional recovery [9].
- SARM use is associated with tendon damage [10].
- TRT within 1 year of rotator cuff repair appears to be a risk factor for multiple postoperative complications [11].
- TRT within 1 year of rotator cuff repair appears to be a risk factor for subsequent shoulder surgery [11].
- Further research is needed to understand the mechanism by which testosterone increases the risk of reoperation after total shoulder arthroplasty [12].
- Testosterone use is associated with a higher risk of infection-related reoperations after total shoulder arthroplasty in male patients [13].
- Testosterone use is associated with a higher risk of all-cause reoperations after total shoulder arthroplasty in male patients [13].
- Patients prescribed at least 3 months of TRT had a significantly higher incidence of ACL injuries compared to controls within a 2-year follow-up period [14].
Key Considerations¶
- Testosterone replacement therapy is associated with increased odds of surgically treated tendon rupture [1].
- Testosterone users had a 2.9-fold increased risk of tendon rupture compared to nonusers [2].
- It is premature to imply causation between testosterone replacement therapy and anterior cruciate ligament injuries based solely on existing results due to confounding variables [3].
- Clinicians should remain vigilant and prescribe testosterone replacement therapy judiciously with a thorough assessment of each patient's unique risk profile [3].
- Findings suggest a threshold-dependent relationship between testosterone and shoulder pathology [4].
- Hormonal status should be considered in musculoskeletal risk assessment [4].
- The use of prescription testosterone is associated with an increased likelihood of experiencing a distal biceps tendon injury [5].
- The use of prescription testosterone is associated with an increased likelihood of subsequently requiring surgical repair for distal biceps tendon injury [5].
- Patients with prior prescription testosterone exposure have an increased rate of distal biceps tendon injury compared with patients without such exposure [5].
- Patients with prior prescription testosterone exposure have an increased rate of biceps tendon repair compared with patients without such exposure [5].
- Surgeons should be more intentional about discussing endocrinologic history with patients [6].
- Surgeons should counsel patients with testosterone deficiency on the risks for injury or re-injury [6].
- Patients who filled a prescription for testosterone replacement therapy were much more likely to experience a quadriceps muscle or tendon injury within 1 year of filling their prescription [7].
- Patients who filled a prescription for testosterone replacement therapy were at increased risk of undergoing surgical repair of the quadriceps tendon [7].
- Testosterone replacement therapy is associated with increased tendon rupture risk in men [8].
- Testosterone replacement therapy is not associated with increased tendon rupture risk in women [8].
- The association between testosterone replacement therapy and increased tendon rupture risk in men but not women may be due to sex-specific differences in dosing [8].
- Anabolic steroid use may contribute to pectoralis major rupture in body builders [9].
- Continuation of anabolic steroids during recovery from pectoralis major rupture does not seem to have a negative effect on functional recovery [9].
- Testosterone replacement therapy within 1 year of rotator cuff repair appears to be a risk factor for multiple postoperative complications [11].
- Testosterone replacement therapy within 1 year of rotator cuff repair appears to be a risk factor for subsequent shoulder surgery [11].
- Further research is needed to understand the mechanism by which testosterone increases the risk of reoperation after total shoulder arthroplasty [12].
Key Evidence¶
- [L3] Testosterone replacement therapy is associated with increased odds of surgically treated tendon rupture. [1] (10.1177/2325967125s00009)
- [L3] Testosterone users had a 2.9-fold increased risk of tendon rupture compared to nonusers. [2] (10.1177/2325967124s00339)
- [L5] It is premature to imply causation between testosterone replacement therapy and ACL injuries based solely on existing results due to confounding variables; clinicians should remain vigilant and prescribe TRT judiciously with a thorough assessment of each patient's unique risk profile. [3] (10.1016/j.arthro.2024.11.086)
- [L3] These findings suggest a threshold-dependent relationship between testosterone and shoulder pathology and highlight the need to consider hormonal status in musculoskeletal risk assessment. [4] (10.1016/j.jse.2026.01.012)
- [L3] Patients with prior prescription testosterone exposure have an increased rate of distal biceps tendon injury and biceps tendon repair compared with patients without such exposure. [5] (10.1016/j.jse.2023.02.122)
- [L5] The author advises surgeons to be more intentional about discussing endocrinologic history with patients and counseling those with testosterone deficiency on the risks for injury or re-injury. [6] (10.1097/corr.0000000000002835)
- [L3] Patients who filled a prescription for testosterone replacement therapy were much more likely to experience a quadriceps muscle or tendon injury within 1 year of filling their prescription and were at increased risk of undergoing surgical repair of the quadriceps tendon. [7] (10.1097/corr.0000000000002744)
- [L3] TRT is associated with increased tendon rupture risk in men but not women, potentially due to sex-specific differences in dosing. [8] (10.1177/23259671261430731)
- [L4] Anabolic steroids use may contribute to the injury, but continuation during recovery does not seem to have a negative effect on functional recovery. [9] (10.1186/s12891-023-06382-1)
- [L4] SARM use is associated with increased muscle mass, hepatotoxicity, cardiotoxicity, tendon damage, and androgenic side effects throughout the body. [10] (10.1177/03635465241252435)
- [L3] TRT within 1 year of rotator cuff repair appears to be a risk factor for multiple postoperative complications and subsequent shoulder surgery. [11] (10.1016/j.jseint.2025.10.002)
- [L3] Further research is needed to understand the mechanism by how testosterone increases the risk of reoperation after TSA. [12] (10.1177/2325967124s00118)
- [L2] Testosterone use is associated with a higher risk of both infection-related and all-cause reoperations after total shoulder arthroplasty. [13] (10.1016/j.jseint.2026.101634)
- [L3] This study found that patients prescribed at least 3 months of TRT had a significantly higher incidence of ACL injuries compared to controls within a 2-year follow-up period. [14] (10.1016/j.arthro.2024.10.032)
- [L3] This finding may represent a musculoskeletal consequence of TRT and is important for patients and clinicians to understand. [15] (10.5435/jaaos-d-22-00554)
- [L3] Testosterone deficiency is associated with poorer postoperative outcomes in total joint arthroplasty, with distinct patterns observed in THA and TKA. [16] (10.5435/jaaos-d-25-00190)
- [L1] The results of our study supported a causal relationship between bioavailable testosterone levels and OA, identifying bioavailable testosterone levels as a risk factor for OA. [17] (10.1186/s12891-025-08626-8)
- [L3] Low testosterone levels are independently associated with an increased risk of OA in the U.S. population. [18] (10.1186/s12891-024-08272-6)
References¶
[1] Testosterone Replacement Therapy Increases Odds of Tendon Ruptures Treated Surgically. Orthopaedic Journal of Sports Medicine. 2025. DOI: 10.1177/2325967125s00009 [2] Poster 374: Tendon Tears Among Patients Treated with Exogenous Therapeutic Anabolic Steroids: An Eight Year Retrospective Analysis in a Single Institution. Orthopaedic Journal of Sports Medicine. 2024. DOI: 10.1177/2325967124s00339 [3] Editorial Commentary: Testosterone Replacement Therapy and Anterior Cruciate Ligament Injury Risk: Insights and Cautions for Clinical Application. Arthroscopy. 2024. DOI: 10.1016/j.arthro.2024.11.086 [4] Testosterone levels and risk of adhesive capsulitis: a 1:1 propensity matched analysis. Journal of Shoulder and Elbow Surgery. 2026. DOI: 10.1016/j.jse.2026.01.012 [5] The use of prescription testosterone is associated with an increased likelihood of experiencing a distal biceps tendon injury and subsequently requiring surgical repair. Journal of Shoulder and Elbow Surgery. 2023. DOI: 10.1016/j.jse.2023.02.122 [6] CORR Insights®: Testosterone Therapy Is Associated With Increased Odds of Quadriceps Tendon Injury. Clinical Orthopaedics & Related Research. 2023. DOI: 10.1097/corr.0000000000002835 [7] Testosterone Therapy Is Associated With Increased Odds of Quadriceps Tendon Injury. Clinical Orthopaedics & Related Research. 2023. DOI: 10.1097/corr.0000000000002744 [8] Testosterone Therapy and Associated Rates of Tendon Tear and Surgical Repair: A Retrospective Analysis. Orthopaedic Journal of Sports Medicine. 2026. DOI: 10.1177/23259671261430731 [9] Pectoralis major rupture in body builders: a case series including anabolic steroid use. BMC Musculoskeletal Disorders. 2023. DOI: 10.1186/s12891-023-06382-1 [10] Athlete Selective Androgen Receptor Modulators Abuse: A Systematic Review. The American Journal of Sports Medicine. 2025. DOI: 10.1177/03635465241252435 [11] Preoperative testosterone replacement therapy: a potential risk-factor for complications and reoperation after rotator cuff repair. JSES International. 2026. DOI: 10.1016/j.jseint.2025.10.002 [12] Poster 149: Supplemental Testosterone Increases Risk of Reoperation after Total Shoulder Arthroplasty. Orthopaedic Journal of Sports Medicine. 2024. DOI: 10.1177/2325967124s00118 [13] Prescription testosterone is associated with increased risk of infection-related and all-cause reoperations after primary total shoulder arthroplasty in male patients. JSES International. 2026. DOI: 10.1016/j.jseint.2026.101634 [14] Prescription Testosterone Is Associated With an Increased Risk of Anterior Cruciate Ligament Injury. Arthroscopy. 2024. DOI: 10.1016/j.arthro.2024.10.032 [15] The Relationship Between Testosterone Therapy and Rotator Cuff Tears, Repairs, and Revision Repairs. Journal of the American Academy of Orthopaedic Surgeons. 2023. DOI: 10.5435/jaaos-d-22-00554 [16] Testosterone Deficiency and Total Joint Arthroplasty Outcomes—A Large Claims Database Study. Journal of the American Academy of Orthopaedic Surgeons. 2025. DOI: 10.5435/jaaos-d-25-00190 [17] The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study. BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-025-08626-8 [18] Correlation between low testosterone levels and the risk of osteoarthritis: a cross-sectional analysis of NHANES data (2011–2016). BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-024-08272-6