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Diabetes and Upper-Limb Conditions

Why diabetes makes frozen shoulder, trigger finger, carpal tunnel syndrome and Dupuytren's more common, and how it affects healing and surgery.

Overview

Diabetes mellitus significantly alters the pathophysiology and clinical presentation of upper-limb conditions, necessitating heightened diagnostic vigilance. In asymptomatic type II diabetes, active glycaemic control and regular upper limb exercise may help delay degeneration of the supraspinatus tendon [1]. Shoulder pain in this population should raise suspicion for frozen shoulder, a condition where the prevalence of prediabetes reaches 37.5% [2, 11]. Furthermore, clinicians must consider spontaneous diabetic myonecrosis in patients presenting with atraumatic acute-onset pain and swelling in the hand to avoid misdiagnosis as inflammatory, infectious, or vascular pathology [3].

Infectious complications are more severe in diabetic cohorts, particularly when glycaemic control is poor [5]. Renal disease and diabetes independently increase the risk of failed outpatient management for cellulitic hand infections, often necessitating inpatient therapy [6]. In elective settings, monitoring HbA1c levels prior to surgery is critical to improving outcomes for diabetic patients undergoing procedures such as carpal tunnel release [9].

Carpal tunnel syndrome in diabetes is mechanistically linked to advanced glycation end products (AGEs) and RAGE expression within the flexor tendon synovium [9]. Obesity exerts a relationship with carpal tunnel syndrome that is similar to or more powerful than diabetes alone, even in the absence of mellitus [10]. The comorbidity of obesity and diabetes suggests an additive effect on the prevalence of this condition [10]. For frozen shoulder related to diabetes, emerging evidence comparing low-level laser therapy versus muscle energy technique may guide future clinical practice [4].

Background & Causes

Diabetes mellitus drives distinct pathological changes across the upper limb, ranging from early tendon degeneration to systemic inflammatory responses. In asymptomatic patients with type II diabetes, early degeneration of the supraspinatus tendon is detectable via shear wave elastography [1]. Altered molecular processes, including oxidative stress response and extracellular matrix organization, contribute to this tendon degeneration and impaired healing [24]. Furthermore, the HMGB1/RAGE/β-catenin axis mediates an aberrant osteogenic-tenogenic differentiation imbalance of tendon stem/progenitor cells in diabetic tendinopathy [25].

Frozen shoulder exhibits strong metabolic associations. Shoulder pain in people with diabetes may be indicative of frozen shoulder [2]. The prevalence of prediabetes is 37.5% in patients with primary frozen shoulder [11]. Type 2 diabetes and fasting glycemic traits are causal factors of frozen shoulder [12]. At the tissue level, matrix metalloproteinase-1 and matrix metalloproteinase-9 are highly expressed in the joint capsule of diabetic frozen shoulder [21]. However, older age and the presence of diabetes mellitus are negative prognostic factors for shoulder manipulation under ultrasound-guided cervical nerve root block for frozen shoulder [7].

Carpal tunnel syndrome in diabetes involves specific molecular and comorbid drivers. Higher RAGE expression is observed in the flexor tendon synovium of diabetic patients with more severe carpal tunnel syndrome [8]. Advanced glycation end products (AGEs) and RAGE expression play a role in the development of carpal tunnel syndrome in diabetic patients [9]. Obesity possesses a similar or more powerful relationship with carpal tunnel syndrome than diabetes alone, and comorbidity of obesity and diabetes suggests an additive effect on increased carpal tunnel syndrome prevalence [10]. Additionally, spontaneous diabetic myonecrosis can present as acute carpal tunnel syndrome in diabetic patients [3].

Systemic glycemic control influences infection severity and soft tissue mechanics. Poor glycaemic control is linked to increased severity of hand infections in diabetic patients [5]. While this section focuses on the upper limb, the broader impact of diabetes on connective tissue is evident in the lower extremity, where increased stiffness and tone in extrinsic foot muscles, Achilles tendon, and plantar fascia may contribute to abnormal foot loading patterns and increased risk of ulcer recurrence in patients with a history of diabetic foot ulcers [19].

Symptoms & Presentation

Shoulder Pathology: Early degeneration of the supraspinatus tendon can occur in asymptomatic patients with type II diabetes mellitus [1]. Shoulder pain in people with diabetes may be indicative of frozen shoulder [2]. The prevalence of prediabetes is 37.5% in patients with primary frozen shoulder [11]. Type 2 diabetes and fasting glycemic traits are causal factors of frozen shoulder [12].

Carpal Tunnel Syndrome: Spontaneous diabetic myonecrosis can present as acute carpal tunnel syndrome, characterized by atraumatic acute-onset pain and swelling in the hand [3]. Higher RAGE expression in flexor tendon synovium is associated with more severe carpal tunnel syndrome in patients with diabetes [8]. Diabetic carpal tunnel syndrome presents with more profound electrophysiological abnormalities compared to non-diabetic cases [16]. Obesity has a similar or more powerful relationship with carpal tunnel syndrome than diabetes alone, and the comorbidity of obesity and diabetes suggests an additive effect on increased carpal tunnel syndrome prevalence [10].

Infection Severity: Diabetic patients with hand infections may present with increased severity of infection linked to poor glycaemic control [5].

Management

Diagnosis and Risk Assessment

Clinicians should maintain a high index of suspicion for frozen shoulder in diabetic patients presenting with shoulder pain [2]. In cases of atraumatic, acute-onset pain and swelling in the hand, spontaneous diabetic myonecrosis must be considered to distinguish it from inflammatory, infectious, or vascular etiologies [3]. For asymptomatic patients with type II diabetes mellitus, active glycemic control and regular upper limb exercise may help delay supraspinatus tendon degeneration [1].

Non-Operative Management

Glycemic Control: Strict glycemic control during the first 3 to 6 months following arthroscopic rotator cuff repair is a modifiable risk factor associated with improved healing rates [14]. Surgeons should consider involving endocrinology colleagues to optimize postoperative glycemic control in select patients undergoing this procedure [14].

Surgical Selection: The success of superior capsular reconstruction (SCR) using fascia lata autograft in strictly controlled diabetic patients should not be generalized to less rigorously managed populations [15]. While preclinical and observational studies provide preliminary support for SGLT2 inhibitors in diabetic rotator cuff disease, high-quality randomized clinical trials are currently lacking [22].

Operative Management

Frozen Shoulder: Older age and the presence of diabetes mellitus are negative prognostic factors for shoulder manipulation under ultrasound-guided cervical nerve root block [7]. There are no significant differences in outcomes between early and delayed arthroscopic release in patients with a history of diabetes mellitus [17].

Carpal Tunnel Release: Preoperative semaglutide use is not associated with a reduction in 90-day complications or 2-year reoperation-free survival in patients with type II diabetes mellitus undergoing carpal tunnel release [13].

Infection Management

Severity and Risk: During the COVID-19 pandemic, hand infections treated were more severe and linked to poor glycaemic control, despite lower attendance volumes [5]. Renal disease and diabetes increase the risk of failed outpatient management for cellulitic hand infections [6].

Disposition: Most patients with diabetic hand infections can be successfully treated as outpatients, although the presence of comorbidities should influence the consideration for inpatient therapy [6].

Key Considerations

Preoperative Assessment and Risk Stratification: Preoperative HbA1c is not a predictive factor for surgical failure requiring reoperation following arthroscopic rotator cuff repair [18]. Preoperative semaglutide use was not associated with a reduction in 90-day complications or 2-year reoperation-free survival in patients with type II diabetes mellitus undergoing carpal tunnel release [13]. Understanding perioperative management guidelines for diabetes is essential for hand surgeons to prevent unexpected day of surgery cancellations [23].

Diabetic Hand Infections: Clinicians should consider spontaneous diabetic myonecrosis in diabetic patients with atraumatic acute-onset pain and swelling in the hand to avoid confusion with other inflammatory, infectious, or vascular conditions [3]. During the COVID-19 pandemic, there was an increased severity of hand infections in treated diabetic patients, linked to poor glycaemic control [5]. Renal disease and diabetes increase the risk of failed outpatient management of cellulitic hand infections, influencing consideration for inpatient therapy [6].

Frozen Shoulder Management: Shoulder pain in people with diabetes could be indicative of frozen shoulder [2]. Older age and the presence of diabetes mellitus are negative prognostic factors for shoulder manipulation under ultrasound-guided cervical nerve root block for frozen shoulder [7]. The findings of a study comparing low-level laser therapy versus muscle energy technique may provide evidence on the efficacy of these interventions and guide clinical practice for frozen shoulder related to diabetes [4].

Carpal Tunnel Syndrome (CTS): Among patients with diabetes who had carpal tunnel syndrome, higher RAGE expression was observed in those with more severe disease, suggesting RAGE-mediated pathways may play a role in the pathophysiology of CTS in patients with diabetes [8]. Diabetic carpal tunnel syndrome had more profound electrophysiological abnormalities compared to non-diabetic cases [16]. There were no significant differences in outcomes between early and delayed arthroscopic release in patients with a history of diabetes mellitus [17].

Rotator Cuff and General Considerations: Active control of diabetes and regular upper limb exercise may help delay supraspinatus tendon degeneration in asymptomatic type II diabetes patients [1]. The success of superior capsular reconstruction using fascia lata autograft in a selected population of strictly controlled patients with diabetes should not be generalized to a less rigorously managed diabetic population [15].

Key Evidence

  • [L3] Active control of the condition of diabetes patients and regular upper limb exercise might help delay the degeneration of supraspinatus tendons. (10.1186/s12891-025-08864-w)
  • [L2] Clinicians should remain alert that shoulder pain in people with diabetes could be indicative of a frozen shoulder. (10.1186/s12891-025-08672-2)
  • [L4] Clinicians should consider this diagnosis in diabetic patients with atraumatic acute-onset pain and swelling in the hand to avoid confusion with other inflammatory, infectious, or vascular conditions. (10.1016/j.jhsg.2021.10.006)
  • [L2] The findings of the study may provide evidence on the efficacy of these interventions and most likely, the optimal treatment approach for frozen shoulder related to diabetes, which may guide clinical practice. (10.1186/s13018-024-04735-7)
  • [L4] While fewer patients attended the service during the pandemic, there was an increased severity of hand infections in those treated, linked to poor glycaemic control. (10.1177/17531934231196026)
  • [L3] These comorbidities should influence consideration for inpatient therapy though most patients can undergo successful treatment as outpatients. (10.1186/s13018-023-03911-5)
  • [L3] Older age and the presence of diabetes mellitus are negative prognostic factors for shoulder manipulation under ultrasound-guided cervical nerve root block. (10.1016/j.jseint.2024.11.022)
  • [L2] Among patients with diabetes who had CTS, higher RAGE expression was observed in those with more severe disease, suggesting that RAGE-mediated pathways may play a role in the pathophysiology of CTS in patients with diabetes. (10.1097/corr.0000000000003800)
  • [Paper] This CORR Insights commentary highlights the role of advanced glycation end products (AGEs) and RAGE expression in the development of carpal tunnel syndrome in diabetic patients, emphasizing the importance of monitoring HbA1c levels before elective surgery to improve outcomes. (10.1097/corr.0000000000003820)
  • [L2] Obesity even without diabetes mellitus may possess a similar or more powerful relationship with carpal tunnel syndrome than diabetes alone, and comorbidity of obesity and diabetes suggests an additive effect on increased carpal tunnel syndrome prevalence. (10.1016/j.jhsg.2025.01.016)
  • [L4] The prevalence of prediabetes is 37.5% in patients with primary frozen shoulder. (10.1016/j.jseint.2023.08.017)
  • [L1] This study supports a genetic causal relationship between type 2 diabetes and fasting glucose and frozen shoulder. (10.1016/j.jse.2023.08.006)
  • [L3] Preoperative semaglutide use was not associated with a reduction in 90-day complications or 2-year reoperation-free survival in patients with type II diabetes mellitus undergoing carpal tunnel release. (10.1016/j.jhsa.2025.09.003)
  • [L5] Strict glycemic control in the first 3 to 6 months after arthroscopic rotator cuff repair is a modifiable risk factor associated with better healing rates, and surgeons should consider engaging endocrinology colleagues to improve postoperative glycemic control in select patients. (10.1016/j.arthro.2022.09.017)
  • [Commentary] The success of SCR using fascia lata autograft in a selected population of strictly controlled patients with diabetes should not be generalized to a less rigorously managed diabetic population. (10.1016/j.arthro.2024.10.015)
  • [L4] Diabetic CTS had more profound electrophysiological abnormalities. (10.1186/s12891-023-06881-1)
  • [L3] There were no significant differences in outcomes between early and delayed arthroscopic release in patients with a history of diabetes mellitus. (10.1016/j.jseint.2023.06.007)
  • [L3] In patients with diabetes mellitus, preoperative HbA1c is not a predictive factor for surgical failure requiring reoperation. (10.1016/j.jse.2023.06.034)
  • [L3] The increased stiffness and tone in these structures may contribute to abnormal foot loading patterns, potentially increasing the risk of ulcer recurrence. (10.1186/s12891-025-08791-w)
  • [L4] The findings of this study demonstrate the potential involvement of MMP-1 and 9 in the pathophysiology of diabetic FS. (10.1016/j.jse.2024.03.062)
  • [L4] Preclinical and observational studies provide preliminary support for the therapeutic benefits of SGLT2 inhibitors in diabetic rotator cuff disease, although high-quality randomized clinical trials are lacking. (10.5397/cise.2024.00969)
  • [L5] Understanding these perioperative management guidelines is essential for hand surgeons to prevent unexpected day of surgery cancellations. (10.1016/j.jhsa.2024.05.018)
  • [L5] Bioinformatic analyses suggested several altered molecular processes, including oxidative stress response and extracellular matrix organization, may contribute to tendon degeneration and impaired healing in diabetes patients. (10.1016/j.jse.2025.07.012)
  • [L5] The findings revealed the critical role of the HMGB1/RAGE/β-catenin axis in the differentiation imbalance of TSPCs and diabetic tendinopathy, highlighting a novel essential mechanism involved in the pathogenesis of diabetic tendinopathy and providing a promising therapeutic target and approach for diabetic tendinopathy. (10.1186/s13018-025-06572-8)

References

[1] Shear wave elastography of the supraspinatus tendon with early degeneration in asymptomatic type II diabetes mellitus patients: a multicenter study. BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-025-08864-w

[2] Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records. BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-025-08672-2

[3] Spontaneous Diabetic Myonecrosis Presenting as Acute Carpal Tunnel Syndrome. Journal of Hand Surgery Global Online. 2022. DOI: 10.1016/j.jhsg.2021.10.006

[4] Comparative effectiveness of low-level laser therapy versus muscle energy technique among diabetic patients with frozen shoulder: a study protocol for a parallel group randomised controlled trial. Journal of Orthopaedic Surgery and Research. 2024. DOI: 10.1186/s13018-024-04735-7

[5] The incidence and severity of diabetic hand infection presentations during the COVID-19 pandemic. Journal of Hand Surgery (European Volume). 2023. DOI: 10.1177/17531934231196026

[6] Renal disease and diabetes increase the risk of failed outpatient management of cellulitic hand infections: a retrospective cohort study. Journal of Orthopaedic Surgery and Research. 2023. DOI: 10.1186/s13018-023-03911-5

[7] Older age and diabetes mellitus are negative prognostic factors for shoulder manipulation under ultrasound-guided cervical nerve root block for frozen shoulder: a retrospective cohort study. JSES International. 2025. DOI: 10.1016/j.jseint.2024.11.022

[8] Is RAGE Expression in Flexor Tendon Synovium Associated With Carpal Tunnel Syndrome in Patients With Diabetes?. Clinical Orthopaedics & Related Research. 2025. DOI: 10.1097/corr.0000000000003800

[9] CORR Insights®: Is RAGE Expression in Flexor Tendon Synovium Associated With Carpal Tunnel Syndrome in Patients With Diabetes?. Clinical Orthopaedics & Related Research. 2026. DOI: 10.1097/corr.0000000000003820

[10] Obesity as a Risk Factor for Carpal Tunnel Syndrome Independent of Diabetes Mellitus: A Nationwide Study. Journal of Hand Surgery Global Online. 2025. DOI: 10.1016/j.jhsg.2025.01.016

[11] Prevalence of prediabetes in patients with idiopathic frozen shoulder: a prospective study. JSES International. 2024. DOI: 10.1016/j.jseint.2023.08.017

[12] Type 2 diabetes and fasting glycemic traits are causal factors of frozen shoulder: a 2-sample Mendelian randomization analysis. Journal of Shoulder and Elbow Surgery. 2024. DOI: 10.1016/j.jse.2023.08.006

[13] Endoscopic and Open Carpal Tunnel Release in Patients With Type II Diabetes Mellitus: Influence of Preoperative Semaglutide Use on Postoperative Outcomes. The Journal of Hand Surgery. 2025. DOI: 10.1016/j.jhsa.2025.09.003

[14] Editorial Commentary : Rotator Cuff Repair in Patients With Diabetes: Stricter Glycemic Control for the First 6 Months Is Associated With Better Healing. Arthroscopy. 2023. DOI: 10.1016/j.arthro.2022.09.017

[15] Editorial Commentary: Both Rotator Cuff Repair and Superior Capsular Reconstruction in Patients With Diabetes Show Good Outcomes When Glucose Is Well Managed. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2025. DOI: 10.1016/j.arthro.2024.10.015

[16] Characteristics of diabetic and non-diabetic carpal tunnel syndrome in terms of clinical, electrophysiological, and Sonographic features: a cross-sectional study. BMC Musculoskeletal Disorders. 2023. DOI: 10.1186/s12891-023-06881-1

[17] Effect of surgical timing in outcomes in Hispanic patients after arthroscopic capsular release in diabetic and idiopathic adhesive capsulitis. JSES International. 2023. DOI: 10.1016/j.jseint.2023.06.007

[18] Elevated HbA1c is not associated with reoperation following arthroscopic rotator cuff repair in patients with diabetes mellitus. Journal of Shoulder and Elbow Surgery. 2024. DOI: 10.1016/j.jse.2023.06.034

[19] Mechanical properties of extrinsic foot muscles, Achilles tendon, and plantar fascia in patients with a history of diabetic foot ulcers. BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-025-08791-w

[21] Matrix metalloproteinase-1 and matrix metalloproteinase-9 are highly expressed in the joint capsule of diabetic frozen shoulder. Journal of Shoulder and Elbow Surgery. 2025. DOI: 10.1016/j.jse.2024.03.062

[22] Potentials of SGLT2 inhibitors in the treatment of diabetic rotator cuff diseases: a comprehensive review. Clinics in Shoulder and Elbow. 2025. DOI: 10.5397/cise.2024.00969

[23] Update on Perioperative Medication Management for the Hand Surgeon: A Focus on Diabetes, Weight Loss, Rheumatologic, and Antithrombotic Medications. The Journal of Hand Surgery. 2024. DOI: 10.1016/j.jhsa.2024.05.018

[24] Genome-wide transcriptional analysis of tendon tissue-related genes and pathways in the torn rotator cuff of diabetes patients. Journal of Shoulder and Elbow Surgery. 2026. DOI: 10.1016/j.jse.2025.07.012

[25] The HMGB1/RAGE/β-catenin axis mediates aberrant osteogenic-tenogenic differentiation imbalance of tendon stem/progenitor cells in diabetic tendinopathy. Journal of Orthopaedic Surgery and Research. 2025. DOI: 10.1186/s13018-025-06572-8

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d. Nothing in this Public License constitutes or may be interpreted as a limitation upon, or waiver of, any privileges and immunities that apply to the Licensor or You, including from the legal processes of any jurisdiction or authority.


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