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Excision of Giant Cell Tumour of Tendon Sheath

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Overview¶
Giant cell tumour of tendon sheath (GCTTS) is a common benign neoplasm of the hand and synovial sheaths that does not metastasize [1, 3, 5]. While typically localized, it can present in atypical locations such as the distal biceps tendon sheath causing anterior elbow symptoms [10] or the wrist causing snapping [11]. Reports in the paediatric population are rare [3]. The condition is characterized by its potential for local recurrence, which remains the primary risk following intervention [2, 5, 6]. Recurrence typically occurs within 36 months of excision [2].
Complete surgical resection is the treatment of choice for most patients with tenosynovial giant cell tumors [4]. Tenosynovial GCTs should be excised as extensively as possible, ideally achieving R0 margins [7]. For localized pigmented villonodular synovitis, arthroscopic excision is the treatment of choice and is currently considered curative [19]. However, diffuse tenosynovial giant cell tumor disease presents challenges due to high recurrence rates [4]. In cases of infiltrative GCTTS, radiation therapy may provide local tumor control while preserving hand function [9].
Regular follow-up evaluations are mandatory for tenosynovial GCTs to monitor for recurrence [7].
Anatomy & Pathophysiology¶
Giant cell tumors may present as separate concomitant lesions on both the volar and dorsal aspects of the same hand [8]. The occurrence of these separate concomitant tumors in the same hand suggests a potential micro-traumatic origin due to repeated back-hand blows [8].
Classification¶
Tenosynovial GCT: This category encompasses tenosynovial giant cell tumors and pigmented villonodular synovitis [4]. Pigmented villonodular synovitis is also known as giant-cell tumor of the tendon sheath and synovial membrane [6]. Giant cell tumors of the tendon sheaths in the hand are benign lesions in which recurrence is the primary risk [5]. Giant cell tumour of tendon sheath is a common benign tumour of the hand that can be locally recurrent after excision, and reports in the paediatric population are rare [3].
Other Considerations: Tenosynovial GCTs should be excised as extensively as possible, ideally with R0 margins, and regular follow-up evaluations are mandatory [7]. There is a case report of lung metastases of diffuse giant cell tumour of the fibular tendon sheath at the ankle [7]. GCTTS may undergo malignant change even though it is rare [14]. There is a case report of multifocal, recurrent, bilateral giant cell tumor of the tendon sheath and pigmented villonodular synovitis involving both upper and lower extremities in an adult [12]. There is a case report of separate concomitant giant cell tumors occurring on both aspects of the same hand [8]. There is a case report of giant cell tumour of the distal biceps tendon sheath in the English language literature [10].
Clinical Presentation¶
Giant cell tumour of tendon sheath (GCTTS) is a common benign tumour of the hand [3]. Although typically presenting in adults, rare paediatric cases exist, including the youngest reported case in a 4-year-old boy [3]. Unusual anatomical presentations include the first documented instance of GCTTS in the distal biceps tendon sheath, which serves as an unusual cause of anterior elbow symptoms [10].
Concomitant or multifocal disease patterns provide insight into potential aetiologies and systemic associations. Separate concomitant GCTTS on both the volar and dorsal aspects of the same hand has been reported, suggesting a potential micro-traumatic origin due to repeated back-hand blows [8]. Rare instances of multifocal, recurrent, bilateral GCTTS and pigmented villonodular synovitis involving both upper and lower extremities in an adult have also been described [12].
GCTTS must be included in the differential diagnosis of soft tissue lesions around the ankle [14]. Clinical presentation can vary from simple masses to complex functional impairments. A snapping wrist may result from a synovial giant cell tumour combined with an anomalous lumbrical muscle [11]. Additionally, posterior interosseous nerve palsy can be secondary to pigmented villonodular synovitis of the elbow [13].
Rare presentations involve extensive involvement of the flexor-tendon sheath of a finger with associated reactive periostitis of the phalanges [22].
Investigations¶
MRI: Magnetic resonance imaging is essential for diagnosing tenosynovial giant cell tumors, accurately defining their localization, and establishing the treatment strategy [30]. It provides valuable diagnostic clues, although definitive diagnosis relies on histopathological confirmation [34]. Pre-operative evaluation with magnetic resonance imaging contributes significantly to the diagnosis of localized pigmented villonous synovitis [35]. In cases of peroneal neuropathy secondary to pigmented villonous synovitis, early diagnosis via magnetic resonance imaging and electromyography is critical for prognosis [36]. Although magnetic resonance imaging findings and location may aid in diagnosis, careful assessment is mandatory, particularly in unusual locations [33].
Treatment¶
Non-Operative¶
Asymptomatic patients with diffuse pigmented villonodysplasia can be successfully managed nonoperatively [26]. For infiltrative GCTTS, radiation therapy may provide local tumor control with preservation of hand function [9].
Operative¶
Indications: Complete surgical resection is the treatment of choice for most patients with tenosynovial giant cell tumors [4]. Complete operative excision is the ideal treatment for pigmented villonodular synovitis [29].
Surgical Approach / Technique: Open synovectomy is the standard method of management for pigmented villonodular synovitis [37]. Arthroscopic excision is effective for the localized type of GCTTS in all four joints [24]. Arthroscopic excision is the preferred treatment for localized pigmented villonodular synovitis due to its effectiveness and minimal morbidity [28]. For diffuse-type GCT with bony erosions, open synovectomy combined with bone grafting is a safe and effective operation for the salvage of the ankle joint [27]. Complete resection of the mass and nerve decompression can lead to complete resolution of symptoms in cases of pigmented villonodular synovitis causing nerve palsy [13].
Complications¶
Recurrence: Recurrence is the primary risk for giant cell tumors of the tendon sheaths in the hand [2, 5]. Giant cell tumor of tendon sheath can be locally recurrent after excision [3]. Recurrence after surgical excision of GCTTS varies widely from 4% to 44%, with incomplete excision being a primary cause [16]. Recurrence typically occurs within 36 months of excision [2]. Diffuse disease presents challenges due to high recurrence rates [4].
Other Considerations: Rare presentations include separate concomitant giant cell tumors occurring on both aspects of the same hand [8]. Multifocal, recurrent, bilateral giant cell tumor of the tendon sheath and pigmented villonodular synovitis involving both upper and lower extremities in an adult has been reported [12].
Recovery¶
Light activity (weeks): Specific timelines for light activity are not detailed in the available evidence.
Full activity (months): Specific timelines for full activity are not detailed in the available evidence.
Complete recovery / outcome plateau (months): Recurrence is the primary risk for giant cell tumors of the tendon sheaths in the hand, typically occurring within 36 months of excision [2]. Complete surgical resection remains the treatment of choice for most patients with tenosynovial giant cell tumors, although diffuse disease presents challenges due to high recurrence rates [4].
Rehabilitation protocol: Specific rehabilitation protocols are not detailed in the available evidence.
Functional milestones: At 2 years after surgery for a synovial giant cell tumour causing snapping wrist, grip strength was equal to the contralateral side with no recurrence of the tumour [11]. Complete resection of the mass and nerve decompression for posterior interosseous nerve palsy secondary to pigmented villonodular synovitis can lead to complete resolution of symptoms even with a long delay in diagnosis [13]. Patients with pigmented villonodular synovitis of the hip managed with arthroscopic synovectomy reported good functional outcomes without evidence of recurrence in a cohort with an average follow-up of almost 7 years [18]. The prognosis after excision of localized pigmented villonodular synovitis of the knee is excellent, with no recurrences observed in one series [39]. Arthroscopic synovectomy following a timely diagnosis of PVNS produces good outcomes in nodular cases, with no evidence of symptomatic or radiographic disease persistence among patients [47].
Other Considerations: The pathogenesis and optimum treatment of pigmented villonodular synovitis remain unclear, with uncertainties persisting due to the rarity of cases, varying reporting details, and lack of long-term follow-up in most series [15].
Key Evidence¶
- [L5] Giant cell tumor of tendon sheath is a benign condition that does not metastasize. [1] (10.1016/s0749-0712(21)00046-9)
- [L4] Giant cell tumors of the tendon sheaths in the hand are benign lesions where recurrence is the primary risk, typically occurring within 36 months of excision. [2] (10.1016/j.otsr.2013.03.008)
- [L4] Giant cell tumour of tendon sheath is a common benign tumour of the hand that can be locally recurrent after excision, and reports in the paediatric population are rare, with this case believed to be the youngest reported. [3] (10.1177/1753193412455792)
- [L5] Complete surgical resection remains the treatment of choice for most patients with tenosynovial giant cell tumors, though diffuse disease presents challenges due to high recurrence rates. [4] (10.5435/jaaos-d-24-01255)
- [L4] Giant cell tumors of the synovial sheaths in the hand are benign lesions in which recurrence is the primary risk. [5] (10.1016/j.jhsa.2013.08.051)
- [L4] Pigmented villonoid synovitis and giant-cell tumor of tendon sheath are benign synovial neoplasms with the potential for local recurrence. [6] (10.2106/00004623-198466010-00012)
- [Case_report] Tenosynovial GCTs should be excised as extensively as possible, ideally with R0 margins, and regular follow-up evaluations are mandatory. [7] (10.1016/j.otsr.2016.10.018)
- [L5] This case describes the first report of separate concomitant giant cell tumors occurring on both aspects of the same hand, suggesting a potential micro-traumatic origin due to repeated back-hand blows over more than 20 years. [8] (10.1007/s12593-015-0185-3)
- [L4] In cases of infiltrative GCTTS, radiation therapy may provide local tumor control with preservation of hand function. [9] (10.1016/j.jhsa.2012.01.011)
- [L4] The authors report the first case of giant cell tumour of the distal biceps tendon sheath in the English language literature, highlighting the importance of considering this condition as a potential cause of anterior elbow symptoms. [10] (10.1177/1758573217701064)
- [Case_report] At 2 years after surgery, the grip strength is equal to the other side and there has been no recurrence of the tumour. [11] (10.1177/1753193409361441)
- [Case_report] This case report describes a rare instance of multifocal, recurrent, bilateral giant cell tumor of the tendon sheath and pigmented villonodular synovitis involving both upper and lower extremities in an adult. [12] (10.1016/j.jhsa.2014.11.010)
- [Case_report] Complete resection of the mass and nerve decompression can lead to complete resolution of symptoms even with a long delay in diagnosis. [13] (10.1016/j.otsr.2012.11.015)
- [L5] GCTTS must be included in the differential diagnosis of a soft tissue lesion around the ankle and may undergo malignant change even though it is rare. [14] (10.1055/s-0039-1679102)
- [L4] The pathogenesis and optimum treatment of pigmented villonodular synovitis remain unclear, with uncertainties persisting due to the rarity of cases, varying reporting details, and lack of long-term follow-up in most series. [15] (10.2106/00004623-198769060-00026)
- [L4] Recurrence after surgical excision of GCTTS varies widely from 4% to 44%, with incomplete excision being a primary cause. [16] (10.1016/j.jhsa.2012.11.001)
- [L4] Patients reported good functional outcomes without evidence of recurrence in a 19 patient cohort with an average follow-up of almost 7 years. [18] (10.1177/2325967119s00413)
- [L4] Arthroscopic excision is the treatment of choice and is currently thought to be curative. [19] (10.1016/j.arthro.2005.12.035)
- [L4] This case describes an unusual presentation of pigmented villonodular tenosynovitis involving the entire flexor-tendon sheath of a finger with associated reactive periostitis of the phalanges, a bone change not previously described in association with this lesion. [22] (10.2106/00004623-197759040-00032)
- [L4] Arthroscopic excision is effective for localized type of GCTTS for all four joints. [24] (10.1016/j.otsr.2017.03.016)
- [L4] Asymptomatic patients can be successfully managed nonoperatively. [26] (10.1302/0301-620x.95b3.30192)
- [L4] For Dt-GCT with bony erosions, open synovectomy combined with bone grafting seems to be a safe and effective operation for the salvage of ankle joint. [27] (10.1186/s12891-017-1824-6)
- [L4] Arthroscopic excision is the preferred treatment due to its effectiveness and minimal morbidity. [28] (10.1007/s00167-003-0448-6)
- [Case_report] The ideal treatment for pigmented villonodular synovitis is complete operative excision. [29] (10.2106/00004623-199072060-00022)
- [L4] Magnetic resonance imaging is essential to diagnose this pathologic condition and to define accurately its localization and treatment strategy. [30] (10.1007/s00167-011-1747-y)
- [L4] Although MRI findings and location might help in the diagnosis of a T-GCT, careful assessment is mandatory, especially in unusual locations. [33] (10.1186/s12891-016-1050-7)
- [L4] MRI provides valuable clues, but definitive diagnosis relies on histopathological confirmation. [34] (10.1186/s12891-026-09563-w)
- [L4] Pre-operative evaluation with MRI made an important contribution to the diagnosis of LPNS. [35] (10.1007/s00167-002-0318-7)
- [Case_report] Early diagnosis via MRI and EMG is very important for prognosis, and early surgical resection of all pathologic tissues is necessary. [36] (10.1007/s00167-009-0720-5)
- [L4] Open synovectomy is the standard method of management. [37] (10.5435/00124635-200606000-00007)
- [L4] The prognosis after excision is excellent, with no recurrences observed in this series. [39] (10.2106/00004623-196749010-00010)
- [L4] Intraoperative dynamic ultrasound application has the potential to be used in repair of the tendon in minimum invasive surgery. [40] (10.1177/1753193415601288)
- [L4] Arthroscopic synovectomy following a timely diagnosis of PVNS produces good outcomes in nodular cases, with no evidence of symptomatic or radiographic disease persistence among these patients. [47] (10.1177/2325967118763118)
See Also¶
References¶
[1] GIANT CELL TUMORS OF TENDON SHEATH. Hand Clinics. 1995. DOI: 10.1016/s0749-0712(21)00046-9
[2] Giant cell tumors of the tendon sheaths in the hand: Review of 96 patients with an average follow-up of 12 years. Orthopaedics & Traumatology: Surgery & Research. 2013. DOI: 10.1016/j.otsr.2013.03.008
[3] Giant cell tumour of tendon sheath in a 4-year-old boy. Journal of Hand Surgery (European Volume). 2012. DOI: 10.1177/1753193412455792
[4] Tenosynovial Giant Cell Tumor and Pigmented Villonodular Synovitis. Journal of the American Academy of Orthopaedic Surgeons. 2025. DOI: 10.5435/jaaos-d-24-01255
[5] Giant Cell Tumors of the Tendon Sheaths in the Hand: Review of 96 Patients With an Average Follow-Up of 12 Years. The Journal of Hand Surgery. 2013. DOI: 10.1016/j.jhsa.2013.08.051
[6] Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases.. The Journal of Bone & Joint Surgery. 1984. DOI: 10.2106/00004623-198466010-00012
[7] Lung metastases of diffuse giant cell tumour of the fibular tendon sheath at the ankle: A case report. Orthopaedics & Traumatology: Surgery & Research. 2017. DOI: 10.1016/j.otsr.2016.10.018
[8] Multiple Giant Cell Tumors of the Tendon Sheath : Separate Volar and Dorsal Lesions Involving Three Digits of the Same Hand Following Repetitive Trauma. Journal of Hand and Microsurgery. 2015. DOI: 10.1007/s12593-015-0185-3
[9] Radiation Therapy for Infiltrative Giant Cell Tumor of the Tendon Sheath. The Journal of Hand Surgery. 2012. DOI: 10.1016/j.jhsa.2012.01.011
[10] Trauma or tumour: giant cell tumour of distal biceps tendon sheath, an unusual cause of elbow pain. Shoulder & Elbow. 2017. DOI: 10.1177/1758573217701064
[11] Snapping wrist caused by synovial giant cell tumour and anomalous lumbrical muscle: a case report. Journal of Hand Surgery (European Volume). 2010. DOI: 10.1177/1753193409361441
[12] Recurrent Pigmented Villonodular Synovitis and Multifocal Giant Cell Tumor of the Tendon Sheath: Case Report. The Journal of Hand Surgery. 2015. DOI: 10.1016/j.jhsa.2014.11.010
[13] Posterior interosseous nerve palsy secondary to pigmented villonodular synovitis of the elbow: Case report and review of literature. Orthopaedics & Traumatology: Surgery & Research. 2013. DOI: 10.1016/j.otsr.2012.11.015
[14] Giant Cell Tumor of Tendon Sheath Developed over Chimeric-Free Latissimus Dorsi and Serratus Anterior Muscle Flaps. Journal of Hand and Microsurgery. 2020. DOI: 10.1055/s-0039-1679102
[15] Pigmented villonodular synovitis.. The Journal of Bone & Joint Surgery. 1987. DOI: 10.2106/00004623-198769060-00026
[16] Giant Cell Tumor of the Tendon Sheath. The Journal of Hand Surgery. 2013. DOI: 10.1016/j.jhsa.2012.11.001
[18] Pigmented Villonodular Synovitis of the Hip Managed with Arthroscopic Synovectomy: An Analysis of 19 Cases with up to 10-year Follow-up. Orthopaedic Journal of Sports Medicine. 2019. DOI: 10.1177/2325967119s00413
[19] Localized Pigmented Villonodular Synovitis: Arthroscopic Treatment of a Lesion Arising From the Quadriceps Tendon Sheath. Arthroscopy. 2006. DOI: 10.1016/j.arthro.2005.12.035
[22] Pigmented Villonodular Tenosynovitis. The Journal of Bone & Joint Surgery. 1977. DOI: 10.2106/00004623-197759040-00032
[24] Giant cell tumor of tendon sheath: Open surgery or arthroscopic synovectomy? A systematic review of the literature. Orthopaedics & Traumatology: Surgery & Research. 2017. DOI: 10.1016/j.otsr.2017.03.016
[26] Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. The Bone & Joint Journal. 2013. DOI: 10.1302/0301-620x.95b3.30192
[27] Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. BMC Musculoskeletal Disorders. 2017. DOI: 10.1186/s12891-017-1824-6
[28] Localized pigmented villonodular synovitis in the anteromedial compartment of the knee associated with cartilage lesions of the medial femoral condyle: report of a case and review of the literature. Knee Surgery, Sports Traumatology, Arthroscopy. 2004. DOI: 10.1007/s00167-003-0448-6
[29] Pigmented villonodular synovitis in a vertebra. A case report.. The Journal of Bone & Joint Surgery. 1990. DOI: 10.2106/00004623-199072060-00022
[30] Arthroscopic treatment of localized pigmented villonodular synovitis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy. 2011. DOI: 10.1007/s00167-011-1747-y
[33] Tenosynovial giant cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant tumors: report of two cases. BMC Musculoskeletal Disorders. 2016. DOI: 10.1186/s12891-016-1050-7
[34] Two rare intra-articsular knee disorders with overlapping symptoms: separate case reports of tenosynovial giant cell tumour and lipoma arborescens and literature review. BMC Musculoskeletal Disorders. 2026. DOI: 10.1186/s12891-026-09563-w
[35] Two contrasting presentations of localised pigmented villonodular synovitis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy. 2002. DOI: 10.1007/s00167-002-0318-7
[36] An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: a case report. Knee Surgery, Sports Traumatology, Arthroscopy. 2009. DOI: 10.1007/s00167-009-0720-5
[37] Pigmented Villonodular Synovitis. Journal of the American Academy of Orthopaedic Surgeons. 2006. DOI: 10.5435/00124635-200606000-00007
[39] Localized Pigmented Villonodular Synovitis of the Knee. The Journal of Bone & Joint Surgery. 1967. DOI: 10.2106/00004623-196749010-00010
[40] Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. Journal of Hand Surgery (European Volume). 2016. DOI: 10.1177/1753193415601288
[47] Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. Orthopaedic Journal of Sports Medicine. 2018. DOI: 10.1177/2325967118763118