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Cannabis and CBD for Pain
What the evidence does and doesn't show for cannabis and CBD in musculoskeletal pain, and practical and safety considerations.
What it is¶
Cannabis-based medicine covers products made from the cannabis plant, including cannabidiol (CBD) and THC. CBD is one part of the plant that does not cause a "high". THC is the part that does. These products come as oils, tablets or creams you can take by mouth or rub on the skin.
People with long-term pain from arthritis, nerve pain, or pain after surgery sometimes ask about these products. Many patients are curious. In one survey, 80.9% of people seeing a hand and upper-limb clinic said they would consider using medical cannabis [1]. Among people with spine pain, one in three were already using it [2]. Large numbers of people with wear-and-tear arthritis at the base of the thumb said they would be interested in trying it [3].
How it works is still being worked out. Your body has its own system that responds to the active parts of cannabis. CBD and THC act on that system, which is thought to affect how you feel pain. Some doctor's see a place for CBD in managing pain after keyhole shoulder surgery and long-term pain [4]. Early work on CBD taken under the tongue after keyhole rotator cuff (shoulder tendon) repair found it showed significant promise in reducing pain in the first days after surgery [5].
The picture is mixed, though. For nerve pain caused by traumatic brachial plexus injuries (stretching or tearing of the nerve network between the neck and arm), trials found no clinically important benefit when cannabis-based treatment was added to standard drug therapy [6]. A synthetic form of THC did not appear to limit opioid intake after knee replacement surgery [7]. Current evidence does show efficacy and safety for chronic musculoskeletal and neuropathic pain [8], but more research is needed before firm advice can be given for many conditions.
Does it work?¶
The honest answer is that it depends on the condition. For long-term muscle, joint and nerve pain, current evidence shows cannabinoids can work and are safe [1]. Reviews also point to a possible role for cannabis-based medicines in peripheral neuropathy, which is pain from nerves outside the brain and spinal cord [2]. But for many hand and arm conditions, the research has not caught up yet, so firm conclusions cannot be drawn [1].
Some findings are encouraging. CBD can be included in a combined pain plan after keyhole rotator cuff repair without harming the result [3], and without long-term harm either [4]. For teenagers and young adults having keyhole hip surgery, marijuana use before the operation did not change their pain levels, painkiller needs, or how well they recovered [5]. They showed marked improvement after surgery whether or not they had used it [5].
Other findings are less clear. Teenagers who reported using marijuana before ACL (knee ligament) reconstruction were more likely to need an overnight stay in hospital for pain and took longer to return to sport [6]. And a study looking at cannabis and nicotine use together after upper limb fracture surgery found no clear added risk, though the study may simply have been too small to detect one [7].
So the picture is genuinely mixed. Some evidence supports cannabis-based medicines for chronic pain conditions. Some shows no effect. Some raises questions in younger patients. If you are considering these products, talk it through with your doctor, who can weigh the evidence for your specific condition.
What are the risks?¶
The honest answer is that the research on safety is still patchy, and it depends on which product you use and why. Here is what the evidence does and does not show.
For CBD taken under the tongue after keyhole shoulder tendon repair, studies found an acceptable safety profile [1]. It could be used as part of a combined pain plan without harming the result of surgery [2], and without long-term harm either [3]. That is the clearest safety signal we have, and it comes from one type of surgery and one way of taking it.
For cannabis-based medicines generally, current evidence shows they can work and are safe for long-term muscle, joint and nerve pain [4]. But that finding comes with a caveat: firm conclusions for many hand and arm conditions need more research [4]. Reviews also point to a possible role in peripheral neuropathy, which is pain from nerves outside the brain and spinal cord [5].
Some findings raise questions rather than reassurance. Teenagers who reported using marijuana before ACL (knee ligament) reconstruction were more likely to need an overnight stay in hospital for pain, and took longer to return to sport [6]. For cannabis and nicotine used together after upper limb fracture surgery, one study found no clear added risk, but it may simply have been too small to detect one [7]. And for nerve pain from traumatic brachial plexus injuries (stretching or tearing of the nerve network between the neck and arm), trials found no clinically important benefit when cannabis-based treatment was added to standard drug therapy [8].
For teenagers and young adults having keyhole hip surgery, marijuana use before the operation did not change pain levels, painkiller needs, or recovery [9].
The overall picture is mixed. If you are considering these products, talk it through with your doctor, who can weigh the evidence for your specific condition.
Is it right for you?¶
There is no simple test for this. The evidence points to some groups where these products may have a place, and others where they probably do not.
If you have long-term muscle, joint or nerve pain, current evidence shows cannabis-based medicines can work and are safe [1]. Reviews also point to a possible role for pain from nerves outside the brain and spinal cord [2]. If you are having keyhole shoulder tendon repair, CBD taken under the tongue has been studied in the first days after surgery and showed significant promise in reducing pain [3], with an acceptable safety profile [3].
Some situations argue against it. If you have nerve pain from a traumatic brachial plexus injury (stretching or tearing of the nerve network between the neck and arm), trials found no clinically important benefit when cannabis-based treatment was added to standard drug therapy [4]. If you are having knee replacement surgery, a synthetic form of THC did not appear to limit opioid (strong painkiller) intake [5]. If you are a teenager facing ACL (knee ligament) reconstruction, reported marijuana use before the operation was linked to a longer hospital stay for pain and a slower return to sport [6].
Compared with standard pain medicines, these products are not a replacement. They are best thought of as one option your doctor might add to a plan that already includes other treatments.
This should be a shared decision with your doctor. They know your condition, your other medicines and your health history, and can weigh the evidence for you specifically.
The bottom line¶
Cannabis-based medicines may have a place in your pain plan, but it depends on your condition. For long-term muscle, joint and nerve pain, the evidence shows they can work and are safe [1]. Reviews also point to a possible role for pain from nerves outside the brain and spinal cord [2]. For many hand and arm conditions, though, the research has not caught up yet [1]. So go in with realistic expectations: these products are one option to consider, not a proven fix for everything. The most important caveat is that the evidence is mixed, so talk it through with your doctor before trying anything.
References
- Hand Surgery Patient Perspectives on Medical Cannabis: A Survey of Over 600 Patients. *Journal of Hand Surgery Global Online*. 2023. 10.1016/j.jhsg.2022.02.009
- Perceptions in orthopedic surgery on the use of cannabis in treating pain: a survey of patients with spine pain (POSIT Spine). *Journal of Orthopaedic Surgery and Research*. 2024. 10.1186/s13018-024-04558-6
- Assessment of Medical Cannabis in Patients With Osteoarthritis of the Thumb Basal Joint. *The Journal of Hand Surgery*. 2023. 10.1016/j.jhsa.2021.10.018
- Poster 373: Perceptions & Opinions on Cannabidiol Among Sports Medicine Orthopaedic Surgeons. *Orthopaedic Journal of Sports Medicine*. 2023. 10.1177/2325967123s00336
- Effects Of Cannabidiol On Post-Operative Pain Following Arthroscopic Rotator Cuff Repair. *Journal of Shoulder and Elbow Surgery*. 2023. 10.1016/j.jse.2023.02.032
- CORR Insights®: Does Cannabis-based Medicine Improve Pain and Sleep Quality in Patients With Traumatic Brachial Plexus Injuries? A Triple-blind, Crossover, Randomized Controlled Trial. *Clinical Orthopaedics & Related Research*. 2024. 10.1097/corr.0000000000003265
- A Synthetic Form of Cannabinoid Does Not Decrease Opioid Use After Total Knee Arthroplasty: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Study. *The Journal of Arthroplasty*. 2026. 10.1016/j.arth.2026.02.047
- Medical Cannabis in Hand Surgery: A Review of the Current Evidence. *The Journal of Hand Surgery*. 2023. 10.1016/j.jhsa.2022.11.008
- The Use of Cannabinoids in the Treatment of Peripheral Neuropathy and Neuropathic Pain: A Systematic Review. *The Journal of Hand Surgery*. 2025. 10.1016/j.jhsa.2024.09.015
- Cannabidiol for Postoperative Pain Control After Arthroscopic Rotator Cuff Repair Demonstrates No Deficits in Patient-Reported Outcomes Versus Placebo: 1-Year Follow-up of a Randomized Controlled Trial. *Orthopaedic Journal of Sports Medicine*. 2024. 10.1177/23259671231222265
- Poster 186: Cannabidiol for Post-Operative Pain Control after Arthroscopic Rotator Cuff Repair Demonstrates No Functional Deficits at 1-Year. *Orthopaedic Journal of Sports Medicine*. 2023. 10.1177/2325967123s00172
- No Evidence That Preoperative Marijuana Use Influences the Success of Hip Arthroscopy for Femoracetabular Impingement in Adolescents and Young Adults. *Orthopaedic Journal of Sports Medicine*. 2025. 10.1177/23259671251385152
- Effect of Marijuana Use on Pain Management and Return to Sport After Anterior Cruciate Ligament Reconstruction in Pediatric and Adolescent Patients: A Matched Control Study. *Orthopaedic Journal of Sports Medicine*. 2025. 10.1177/23259671251369015
- Cannabis and nicotine use are independently associated with adverse surgical, medical, and psychosocial outcomes following upper extremity fracture fixation. *Journal of Orthopaedic Surgery and Research*. 2026. 10.1186/s13018-025-06635-w
Evidence & references
This is the clinical evidence summary written for health professionals. It is technical, and it lists the research this page was built from. You do not need to read it to understand your treatment or to make a decision about it.
Overview¶
- Cannabidiol (CBD) can be considered in a postoperative multimodal pain management regimen without detrimental effects on patient-reported outcomes at 1-year follow-up after arthroscopic rotator cuff repair [1].
- CBD can be considered in a postoperative multimodal pain management regimen without long-term functional deficits at 1-year follow-up after arthroscopic rotator cuff repair [2].
- Cannabis-based medicines are applicable for the treatment of peripheral neuropathy and neuropathic pain [3].
- 89% of participants in a survey of musculoskeletal pain patients considered medical cannabis to be more effective than narcotics for adequate pain management [4].
- Regular cannabis use may be associated with increased opioid usage in the context of total joint arthroplasty [5].
- No specific guidance for the use of cannabis in perioperative pain management can be suggested based on the association between regular cannabis use and increased opioid usage after total joint arthroplasty [5].
- Patients estimated that medical cannabis could treat more than half of their spine pain [6].
- One in three patients with spine pain were already using medical cannabis [6].
- 79% of patients with spine pain believe cannabis could reduce opioid usage [6].
- Most survey respondents in the orthopaedic sports medicine community believed that CBD has a role in postoperative and chronic pain management [7].
- Large numbers of patients with osteoarthritis of the thumb basal joint would be interested in trialing either oral or topical formulations of medical cannabis for treatment of their pain [8].
- 80.9% of patients presenting for hand and upper-extremity complaints would consider using medical cannabis [9].
- Patients presenting for hand and upper-extremity complaints perceive medical cannabis as a safe treatment option for common orthopedic conditions [9].
- Cost is identified as a major barrier to the use of medical cannabis by patients presenting for hand and upper-extremity complaints [9].
- A synthetic form of THC does not appear to limit opioid intake after primary total knee arthroplasty [10].
- Current evidence demonstrates efficacy and safety for chronic musculoskeletal and neuropathic pain [19].
- Definitive conclusions regarding the efficacy of medical cannabis in hand and upper extremity conditions require continued investigation [19].
How It Works¶
- Cannabidiol (CBD) can be considered in a postoperative multimodal pain management regimen without long-term functional deficits at 1-year follow-up after arthroscopic rotator cuff repair [2].
- 89% of participants considered medical cannabis to be more effective than narcotics for adequate pain management [4].
- No specific guidance in the use of cannabis in perioperative pain management can be suggested based on the association between regular cannabis use and increased opioid usage after total joint arthroplasty [5].
- Cannabis-based medicine did not provide clinical improvement in pain compared with a placebo in patients with traumatic brachial plexus injuries [11].
- A majority of sports medicine surgeons believe that CBD has a role in post-operative and chronic pain management [12].
- More clinical research for cannabinoids is needed to help orthopaedic traumatologists provide guidance for patients seeking advice for this therapeutic [13].
- Patients with documented cannabis dependence demonstrated higher odds of developing wound complications following hand and wrist soft-tissue surgical procedures [16].
What the Evidence Shows¶
Postoperative Pain Management¶
- CBD can be considered in a post-operative multimodal pain management regimen without long-term functional deficits at 1-year follow-up after arthroscopic rotator cuff repair [2].
- Buccally absorbed CBD demonstrates an acceptable safety profile and shows significant promise in reducing pain in the immediate peri-operative period following arthroscopic rotator cuff repair compared to control [17].
- Cannabis use does not affect outcomes after total hip arthroplasty [14].
- Further studies are warranted to determine the efficacy and safety of perioperative cannabis use after total hip arthroplasty to help guide orthopaedic surgeons in counseling patients [14].
- Higher-level studies are needed to ascertain the impact of cannabis use for patients undergoing total joint arthroplasty [15].
Neuropathic Pain¶
- Cannabis-based treatment did not provide clinically important benefit as an adjuvant to standard multimodal drug therapy for neuropathic pain in traumatic brachial plexus injuries [18].
- Findings suggest the applicability of cannabis-based medicines for peripheral neuropathy [3].
Patient and Surgeon Perceptions¶
- Patients estimated medical cannabis could treat more than half of their spine pain [6].
Practical Considerations¶
Postoperative Pain Management¶
- CBD can be considered in a postoperative multimodal pain management regimen without detrimental effects on outcome [1].
- CBD can be considered in a post-operative multimodal pain management regimen without long-term detrimental effects [2].
Patient and Provider Perceptions¶
- Large numbers of patients with osteoarthritis of the thumb basal joint would be interested in trialing either oral or topical formulations of medical cannabis for treatment of their thumb basal joint pain [8].
Clinical Guidance and Research Needs¶
- No specific guidance in the use of cannabis in perioperative pain management can be suggested based on the association between regular cannabis use and increased opioid usage in total joint arthroplasty [5].
- More clinical research for cannabinoids is needed to help orthopaedic traumatologists provide guidance for patients seeking advice [13].
Key Evidence¶
- [L2] These findings suggest that CBD can be considered in a postoperative multimodal pain management regimen without detrimental effects on outcome. [1] (10.1177/23259671231222265)
- [L2] These findings suggest that CBD can be considered in a post-operative multimodal pain management regimen without long-term detrimental effects. [2] (10.1177/2325967123s00172)
- [L2] These findings suggest the applicability of cannabis-based medicines for peripheral neuropathy. [3] (10.1016/j.jhsa.2024.09.015)
- [L4] In addition, 89% of the participants considered medical cannabis to be more effective than narcotics for adequate pain management. [4] (10.5435/jaaosglobal-d-22-00055)
- [Paper] Regular cannabis use may be associated with increased opioid usage in the context of total joint arthroplasty, and no specific guidance in the use of cannabis in perioperative pain management can be suggested based on this discovery. [5] (10.1097/corr.0000000000003472)
- [L4] Patients estimated medical cannabis could treat more than half of their spine pain, with one in three patients already using medical cannabis, and 79% of patients believe cannabis could reduce opioid usage. [6] (10.1186/s13018-024-04558-6)
- [L4] Most survey respondents believed that CBD has a role in postoperative and chronic pain management. [7] (10.1177/23259671231191766)
- [L4] Large numbers of these patients would be interested in trialing either oral or topical formulations of medical cannabis for treatment of their thumb basal joint pain. [8] (10.1016/j.jhsa.2021.10.018)
- [L3] Most patients presenting for hand and upper-extremity complaints would consider using medical cannabis (80.9%) and perceive it as a safe treatment option for common orthopedic conditions, with cost identified as a major barrier to use. [9] (10.1016/j.jhsg.2022.02.009)
- [L1] Despite enthusiasm for cannabis after orthopaedic surgical procedures, this THC does not appear to limit opioid intake after primary TKA. [10] (10.1016/j.arth.2026.02.047)
- [L1] Cannabis-based medicine did not provide clinical improvement in pain compared with a placebo in patients with traumatic brachial plexus injuries. [11] (10.1097/corr.0000000000003221)
- [L4] A majority of sports medicine surgeons believe that CBD has a role in post-operative and chronic pain management. [12] (10.1177/2325967123s00336)
- [L4] More clinical research for cannabinoids is needed to help orthopaedic traumatologists provide guidance for patients seeking advice for this recently popular therapeutic. [13] (10.5435/jaaosglobal-d-21-00047)
- [L3] Further studies are warranted to determine the efficacy and safety of perioperative cannabis use after THA to help guide orthopaedic surgeons in counseling patients. [14] (10.1016/j.arth.2023.03.040)
- [L1] Higher-level studies are needed to ascertain the impact of cannabis use for patients undergoing TJA. [15] (10.1016/j.arth.2023.07.008)
- [L2] Patients with documented cannabis dependence demonstrated higher odds of developing wound complications following hand and wrist soft-tissue surgical procedures. [16] (10.1016/j.jhsg.2026.100948)
- [L1] Buccally absorbed CBD demonstrates an acceptable safety profile and shows significant promise in reduction of pain in the immediate peri-operative period following ARCR compared to the control. [17] (10.1016/j.jse.2023.02.032)
- [Paper] This is a commentary on a randomized controlled trial by Kittithamvongs et al., which found no clinically important benefit to cannabis-based treatment as an adjuvant to standard multimodal drug therapy for neuropathic pain in traumatic brachial plexus injuries. [18] (10.1097/corr.0000000000003265)
- [L4] Current evidence demonstrates efficacy and safety for chronic musculoskeletal and neuropathic pain, but definitive conclusions regarding efficacy in hand and upper extremity conditions require continued investigation. [19] (10.1016/j.jhsa.2022.11.008)
References¶
[1] Cannabidiol for Postoperative Pain Control After Arthroscopic Rotator Cuff Repair Demonstrates No Deficits in Patient-Reported Outcomes Versus Placebo: 1-Year Follow-up of a Randomized Controlled Trial. Orthopaedic Journal of Sports Medicine. 2024. DOI: 10.1177/23259671231222265
[2] Poster 186: Cannabidiol for Post-Operative Pain Control after Arthroscopic Rotator Cuff Repair Demonstrates No Functional Deficits at 1-Year. Orthopaedic Journal of Sports Medicine. 2023. DOI: 10.1177/2325967123s00172
[3] The Use of Cannabinoids in the Treatment of Peripheral Neuropathy and Neuropathic Pain: A Systematic Review. The Journal of Hand Surgery. 2025. DOI: 10.1016/j.jhsa.2024.09.015
[4] Patient Experience and Perspective on Medical Cannabis as an Alternative for Musculoskeletal Pain Management. JAAOS: Global Research and Reviews. 2022. DOI: 10.5435/jaaosglobal-d-22-00055
[5] CORR Insights®: Do Medical and Recreational Marijuana State Laws Impact Trends in Postoperative Opioid Prescriptions Among Patients Who Have Undergone TJA?. Clinical Orthopaedics & Related Research. 2025. DOI: 10.1097/corr.0000000000003472
[6] Perceptions in orthopedic surgery on the use of cannabis in treating pain: a survey of patients with spine pain (POSIT Spine). Journal of Orthopaedic Surgery and Research. 2024. DOI: 10.1186/s13018-024-04558-6
[7] Perceptions and Opinions on Cannabidiol in the Orthopaedic Sports Medicine Community. Orthopaedic Journal of Sports Medicine. 2023. DOI: 10.1177/23259671231191766
[8] Assessment of Medical Cannabis in Patients With Osteoarthritis of the Thumb Basal Joint. The Journal of Hand Surgery. 2023. DOI: 10.1016/j.jhsa.2021.10.018
[9] Hand Surgery Patient Perspectives on Medical Cannabis: A Survey of Over 600 Patients. Journal of Hand Surgery Global Online. 2023. DOI: 10.1016/j.jhsg.2022.02.009
[10] A Synthetic Form of Cannabinoid Does Not Decrease Opioid Use After Total Knee Arthroplasty: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Study. The Journal of Arthroplasty. 2026. DOI: 10.1016/j.arth.2026.02.047
[11] Does Cannabis-based Medicine Improve Pain and Sleep Quality in Patients With Traumatic Brachial Plexus Injuries? A Triple-blind, Crossover, Randomized Controlled Trial. Clinical Orthopaedics & Related Research. 2024. DOI: 10.1097/corr.0000000000003221
[12] Poster 373: Perceptions & Opinions on Cannabidiol Among Sports Medicine Orthopaedic Surgeons. Orthopaedic Journal of Sports Medicine. 2023. DOI: 10.1177/2325967123s00336
[13] Knowledge and Opinion on Cannabinoids Among Orthopaedic Traumatologists. JAAOS: Global Research and Reviews. 2021. DOI: 10.5435/jaaosglobal-d-21-00047
[14] Cannabis Use Does Not Affect Outcomes After Total Hip Arthroplasty. The Journal of Arthroplasty. 2023. DOI: 10.1016/j.arth.2023.03.040
[15] Cannabis Use Following Total Joint Arthroplasty is Associated With Increased Risks? A Meta-Analysis. The Journal of Arthroplasty. 2024. DOI: 10.1016/j.arth.2023.07.008
[16] Is Cannabis Dependence Associated with Postoperative Infections in Hand and Wrist Surgeries?. Journal of Hand Surgery Global Online. 2026. DOI: 10.1016/j.jhsg.2026.100948
[17] Effects Of Cannabidiol On Post-Operative Pain Following Arthroscopic Rotator Cuff Repair. Journal of Shoulder and Elbow Surgery. 2023. DOI: 10.1016/j.jse.2023.02.032
[18] CORR Insights®: Does Cannabis-based Medicine Improve Pain and Sleep Quality in Patients With Traumatic Brachial Plexus Injuries? A Triple-blind, Crossover, Randomized Controlled Trial. Clinical Orthopaedics & Related Research. 2024. DOI: 10.1097/corr.0000000000003265
[19] Medical Cannabis in Hand Surgery: A Review of the Current Evidence. The Journal of Hand Surgery. 2023. DOI: 10.1016/j.jhsa.2022.11.008