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GLP-1 Receptor Agonists and Orthopaedic Surgery

How GLP-1 receptor agonists (semaglutide and related drugs) affect orthopaedic and arthroplasty patients — perioperative risk, weight optimisation, bone and fracture healing, and infection or revision risk.

Overview

Orthopaedic surgeons will increasingly encounter patients using glucagon-like peptide-1 (GLP-1) receptor agonists, necessitating a clear understanding of their perioperative implications [3]. These agents are recognized as a promising tool for preoperative weight loss in patients with obesity and type-2 diabetes mellitus undergoing orthopaedic surgery [9]. Patients taking GLP-1 receptor agonists experience noninferior clinical outcomes with the potential for weight loss leading up to total knee arthroplasty [20].

Evidence suggests that GLP-1 agonist use does not increase the odds of postoperative medical and surgical complications across various arthroplasty procedures. In nondiabetic patients taking these medications for weight loss alone, primary total hip arthroplasty outcomes remain unaffected [1]. Similarly, GLP-1 agonist use is not significantly associated with 90-day or 2-year adverse events following total shoulder arthroplasty [2], nor is it associated with increased risks for medical or surgical complications in patients with type 2 diabetes undergoing total hip arthroplasty [12]. Among patients undergoing first metatarsophalangeal joint arthrodesis, GLP-1 RA use was not associated with differences in overall complication rates in the general population [16]. Furthermore, patients using GLP-1 receptor agonists have noninferior clinical outcomes with similar risks of all examined complications as those who were not prescribed GLP-1 receptor agonists after anatomic total shoulder arthroplasty [13].

Beyond safety, GLP-1 receptor agonists may offer protective benefits. Preoperative use may be linked to reduced readmission risk following joint arthroplasty, without evidence of increased postoperative medical harm [8]. Administration for at least 90 days prior to and after primary total knee arthroplasty in patients with a BMI of ≥40 kg/m2 was associated with reductions in the risks of 90-day periprosthetic joint infection, any medical complications, and readmission [10]. GLP-1 RA use was associated with improved early surgical outcomes and decreased resource utilization following total hip and total knee arthroplasty [17], as well as lower rates of extended hospital stays after surgery in diabetic patients [12]. Findings from cubital tunnel decompression in diabetic patients support a potential protective role of GLP-1 receptor agonists in this surgical population [6].

While GLP-1 receptor agonists show potential to reduce postoperative complications in total joint arthroplasty, findings remain inconsistent, and further research is needed to clarify their impact on outcomes and establish perioperative management guidelines [4]. More research is needed to better understand the relationship between GLP-1-induced weight loss, musculoskeletal health, and perioperative outcomes, particularly in women arthroplasty patients, who are both more likely to use these medications and also at higher risk for periprosthetic fractures [5]. The benefits of GLP-1 therapy might limit infection risk; however, additional research is needed to understand the effect these medications make on patient nutrition and bone metabolism [7].

Effects on Surgery and Recovery

Arthroplasty surgeons will encounter an increasing number of patients on GLP-1 agonists, making it important to understand the implications of their use in the perioperative period [3]. GLP-1 receptor agonists are a promising tool for preoperative weight loss in patients with obesity and type-2 diabetes mellitus undergoing orthopaedic surgery [9]. GLP-1 RA use may be a preferred option for preoperative weight loss optimization in total knee arthroplasty compared to bariatric surgery [19]. Preoperative GLP-1 RA use is associated with lower complication risks compared to bariatric surgery and demonstrates a safety profile comparable to no weight-loss intervention following primary total hip arthroplasty [21].

Total Hip Arthroplasty: GLP-1 agonist use does not appear to increase the odds of postoperative medical and surgical complications in nondiabetic patients taking GLP-1 medications for weight loss alone [1]. In patients with type 2 diabetes, GLP-1 agonists were not associated with increased risks for medical or surgical complications and were associated with lower rates of extended hospital stays after surgery [12]. Preoperative GLP-1 RA use is associated with a 42% decreased risk of periprosthetic joint infection and 47% decreased risk of readmission in the 90-day postoperative period, with no difference in other risks, including aspiration [26]. GLP-1 RA administration for at least 90 days prior to and after primary total knee arthroplasty in patients with a BMI of ≥40 kg/m2 was associated with reductions in the risks of 90-day periprosthetic joint infection, any medical complications, and readmission [10]. Perioperative use of GLP-1 RA in patients with morbid obesity is associated with reduced risk of acute periprosthetic joint infection and 90-day hospital readmission [22]. Preoperative glucagon-like peptide-1 receptor agonist use may be linked to reduced readmission risk following joint arthroplasty, without evidence of increased postoperative medical harm [8]. Current observational data suggest that perioperative GLP-1 RA use in patients undergoing total hip or knee arthroplasty is not associated with a consistent increase in short-term revision rates and may be associated with a reduced risk of postoperative infection [14].

Total Shoulder Arthroplasty: GLP-1 agonist use is not significantly associated with 90-day or 2-year adverse events following total shoulder arthroplasty [2]. Patients taking GLP-1 receptor agonists experienced similar risks of all examined complications as those who were not prescribed GLP-1 receptor agonists after anatomic total shoulder arthroplasty [13]. The lack of increased postoperative risk underscores the potential of GLP-1 therapy in managing type 2 diabetes without adverse effects on total shoulder arthroplasty recovery [15]. However, GLP-1 receptor agonist use during total shoulder arthroplasty was associated with an increased risk of deep vein thrombosis, myocardial infarction, pneumonia, need for transfusion, and readmission [25].

Other Orthopaedic Procedures: GLP-1 RA use appears safe in the perioperative period for patients undergoing arthroscopic rotator cuff repair [11]. Among patients undergoing first metatarsophalangeal joint arthrodesis, GLP-1 RA use was not associated with differences in overall complication rates in the general population [16]. Patients taking GLP-1 agonists were not at higher risk for 90-day postoperative infections including surgical site infections and wound dehiscence following common hand procedures [23]. Findings from cubital tunnel decompression in diabetic patients receiving glucagon-like peptide-1 receptor agonists support a potential protective role of GLP-1RAs in this surgical population [6].

The benefits of GLP-1 therapy might limit infection risk, however additional research is needed to understand the effect these medications make on patient nutrition and bone metabolism [7]. While GLP-1 receptor agonists show potential to reduce postoperative complications in total joint arthroplasty, findings remain inconsistent, and further research is needed to clarify their impact on outcomes and establish perioperative management guidelines [4]. More research is needed to better understand the relationship between GLP-1-induced weight loss, musculoskeletal health, and perioperative outcomes, particularly in women arthroplasty patients, who are both more likely to use these medications and also at higher risk for periprosthetic fractures [5]. Conflicting findings highlight the need for further research, particularly well-designed multicenter studies and randomized controlled trials, to clarify the effects of GLP-1 RAs on surgical outcomes [18].

Practical Considerations

Arthroplasty surgeons will encounter an increasing number of patients on GLP-1 agonists, making it important to understand the implications of their use in the perioperative period [3]. Semaglutide and other GLP-1 agonists may increase the number of eligible candidates for elective total joint arthroplasty by enabling weight loss and improving diabetic control [24]. GLP-1 receptor agonist use may be a preferred option for preoperative weight loss optimization in total knee arthroplasty compared to bariatric surgery [19].

Safety Profile: GLP-1 agonist use does not appear to increase the odds of postoperative medical and surgical complications after primary total hip arthroplasty in nondiabetic patients taking these medications for weight loss alone [1]. GLP-1 agonist use is not significantly associated with 90-day or 2-year adverse events following total shoulder arthroplasty [2]. The lack of increased postoperative risk in shoulder arthroplasty underscores the potential of GLP-1 therapy in managing type 2 diabetes without adverse effects on total shoulder arthroplasty recovery [15]. GLP-1 receptor agonist use appears safe in the perioperative period for patients undergoing arthroscopic rotator cuff repair [11]. Current observational data suggest that perioperative GLP-1 receptor agonist use in patients undergoing total hip or knee arthroplasty is not associated with a consistent increase in short-term revision rates [14].

Outcomes and Complications: Preoperative glucagon-like peptide-1 receptor agonist use may be linked to reduced readmission risk following joint arthroplasty, without evidence of increased postoperative medical harm [8]. GLP-1 receptor agonist use was associated with improved early surgical outcomes and decreased resource utilization following total hip and total knee arthroplasty [17]. Perioperative GLP-1 receptor agonist use in patients undergoing total hip or knee arthroplasty may be associated with a reduced risk of postoperative infection [14]. Semaglutide and other GLP-1 agonists may potentially reduce postoperative complications such as sepsis and prosthetic joint infections [24]. Findings from cubital tunnel decompression in diabetic patients support a potential protective role of GLP-1 receptor agonists in this surgical population [6].

Research Gaps: GLP-1 receptor agonists show potential to reduce postoperative complications in total joint arthroplasty, but findings remain inconsistent and further research is needed to clarify their impact on outcomes and establish perioperative management guidelines [4]. Conflicting findings highlight the need for further research, particularly well-designed multicenter studies and randomized controlled trials, to clarify the effects of GLP-1 receptor agonists on surgical outcomes [18]. More research is needed to better understand the relationship between GLP-1-induced weight loss, musculoskeletal health, and perioperative outcomes, particularly in women arthroplasty patients who are more likely to use these medications and at higher risk for periprosthetic fractures [5]. The benefits of GLP-1 therapy might limit infection risk, but additional research is needed to understand the effect these medications have on patient nutrition and bone metabolism [7].

Key Evidence

  • [L3] Use of a GLP-1 agonist does not appear to increase the odds of postoperative medical and surgical complications after THA in nondiabetic patients taking GLP-1 medications for weight loss alone. (10.1016/j.arth.2025.03.012)
  • [L1] GLP-1 agonist use is not significantly associated with 90-day or 2-year adverse events following total shoulder arthroplasty. (10.1016/j.jse.2025.12.005)
  • [L5] Arthroplasty surgeons will encounter an increasing number of patients on GLP-1 agonists, making it important to understand the implications of their use in the perioperative period. (10.1016/j.arth.2023.12.002)
  • [L5] The paper concludes that while GLP-1 receptor agonists show potential to reduce postoperative complications in total joint arthroplasty, findings remain inconsistent, and further research is needed to clarify their impact on outcomes and establish perioperative management guidelines. (10.1016/j.arth.2025.10.027)
  • [L5] More research is needed to better understand the relationship between GLP-1-induced weight loss, musculoskeletal health, and perioperative outcomes, particularly in women arthroplasty patients, who are both more likely to use these medications and also at higher risk for periprosthetic fractures. (10.1016/j.arth.2026.03.063)
  • [L3] These findings support a potential protective role of GLP-1RAs in this surgical population. (10.5397/cise.2025.00801)
  • [L3] The benefits of GLP-1 therapy might limit infection risk, however additional research is needed to understand the effect these medications make on patient nutrition and bone metabolism. (10.5435/jaaos-d-24-01284)
  • [L1] Preoperative glucagon-like peptide-1 receptor agonist use may be linked to reduced readmission risk following joint arthroplasty, without evidence of increased postoperative medical harm. (10.1016/j.arth.2025.11.036)
  • [L5] GLP-1 receptor agonists are a promising tool for preoperative weight loss in patients with obesity and type-2 diabetes mellitus undergoing orthopaedic surgery. (10.2106/jbjs.24.01287)
  • [L3] GLP-1 RA administration for at least 90 days prior to and after primary TKA in patients with a BMI of ≥40 kg/m2 was associated with reductions in the risks of 90-day PJI, any medical complications, and readmission. (10.2106/jbjs.24.00468)
  • [L3] These findings suggest that GLP-1RA use appears safe in the perioperative period for patients undergoing arthroscopic RCR. (10.1177/23259671251412408)
  • [L3] This study demonstrated that GLP-1 agonists were not associated with increased risks for medical or surgical complications in patients who had DM undergoing THA and were associated with lower rates of extended hospital stays after surgery. (10.1016/j.arth.2024.10.099)
  • [L3] Patients taking GLP-1 RAs experienced similar risks of all examined complications as those who were not prescribed GLP-1 RAs. (10.1177/2325967125s00120)
  • [L4] Current observational data suggest that perioperative GLP-1 RA use in patients undergoing total hip or knee arthroplasty is not associated with a consistent increase in short-term revision rates and may be associated with a reduced risk of postoperative infection. (10.1186/s42836-026-00375-w)
  • [L3] The lack of increased postoperative risk underscores the potential of GLP-1 therapy in managing T2DM without adverse effects on TSA recovery. (10.1016/j.jse.2024.07.045)
  • [L3] Among patients undergoing first MTPJ arthrodesis, GLP-1 RA use was not associated with differences in overall complication rates in the general population. (10.5435/jaaos-d-26-00153)
  • [L1] GLP-1RA use was associated with improved early surgical outcomes and decreased resource utilization following THA and TKA. (10.1016/j.arth.2025.09.054)
  • [L4] However, conflicting findings highlight the need for further research, particularly well-designed multicenter studies and randomized controlled trials, to clarify the effects of GLP-1 RAs on surgical outcomes. (10.1016/j.arth.2025.07.015)
  • [L3] These findings suggest that GLP-1 RA use may be a preferred option for preoperative weight loss optimization in TKAs. (10.1016/j.arth.2025.08.073)
  • [L3] Patients using GLP-1RAs have noninferior clinical outcomes with the potential for weight loss leading up to TKA. (10.1016/j.arth.2025.02.042)
  • [L3] Preoperative GLP-1 RA use is associated with lower complication risks compared to bariatric surgery and demonstrates a safety profile comparable to no weight-loss intervention. (10.1016/j.arth.2026.04.032)
  • [L3] Perioperative use of GLP-1 RA in patients who had morbid obesity is associated with reduced risk of acute periprosthetic joint infection and 90-day hospital readmission. (10.1016/j.arth.2024.12.008)
  • [L3] This study found that patients taking GLP-1 agonists were not at higher risk for 90-day postoperative infections including surgical site infections and wound dehiscence. (10.1016/j.jhsa.2025.08.004)
  • [L5] Semaglutide and other GLP-1 agonists may increase the number of eligible candidates for elective total joint arthroplasty by enabling weight loss and improving diabetic control, while also potentially reducing postoperative complications such as sepsis and prosthetic joint infections. (10.1016/j.arth.2023.12.014)
  • [L3] GLP-1 receptor agonist use during total shoulder arthroplasty was associated with an increased risk of deep vein thrombosis, myocardial infarction, pneumonia, need for transfusion, and readmission. (10.1016/j.jse.2024.09.012)
  • [L3] Preoperative GLP-1 RA use is associated with a 42% decreased risk of periprosthetic joint infection and 47% decreased risk of readmission in the 90-day postoperative period following THA and TKA, respectively, with no difference in other risks, including aspiration. (10.1016/j.arth.2024.05.079)

References

[1] GLP-1 Agonists for Weight Loss: Do They Increase Complications in Non-diabetic Patients Undergoing Primary Total Hip Arthroplasty?. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.03.012

[2] GLP-1 receptor agonist therapy is not associated with adverse events following shoulder surgery: a systematic review and meta-analysis. Journal of Shoulder and Elbow Surgery. 2026. DOI: 10.1016/j.jse.2025.12.005

[3] The Impact of Glucagon-Like Peptide-1 Agonists on Hip and Knee Arthroplasty and Perioperative Considerations. The Journal of Arthroplasty. 2024. DOI: 10.1016/j.arth.2023.12.002

[4] Glucagon-Like Peptide-1 Receptor Agonists: Have We Found the Holy Grail for Total Joint Arthroplasty?. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.10.027

[5] GLP-1 Receptor Agonist Weight Loss Therapy and Arthroplasty: Are Women at Greater Risk for Complications?. The Journal of Arthroplasty. 2026. DOI: 10.1016/j.arth.2026.03.063

[6] Characteristics and outcomes of cubital tunnel decompression in diabetic patients receiving glucagon-like peptide-1 receptor agonists. Clinics in Shoulder and Elbow. 2025. DOI: 10.5397/cise.2025.00801

[7] The Effects of Glucagon-Like Peptide-1 Agonist Therapy on Risk of Infection, Fracture, and Early Revision in Primary Total Joint Arthroplasty. Journal of the American Academy of Orthopaedic Surgeons. 2025. DOI: 10.5435/jaaos-d-24-01284

[8] Glucagon-Like Peptide-1 Receptor Agonists, Readmission, and Postoperative Complications in Arthroplasty: A Systematic Review and Meta-Analysis. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.11.036

[9] GLP-1 Receptor Agonists in Orthopaedic Surgery: Implications for Perioperative Care and Outcomes. Journal of Bone and Joint Surgery. 2025. DOI: 10.2106/jbjs.24.01287

[10] Glucagon-Like Peptide-1 Receptor Agonists Decrease Medical and Surgical Complications in Morbidly Obese Patients Undergoing Primary TKA. Journal of Bone and Joint Surgery. 2024. DOI: 10.2106/jbjs.24.00468

[11] Effect of Glucagon-like Peptide-1 Receptor Agonists on Outcomes and Complications Following Arthroscopic Rotator Cuff Repair: A Matched-Cohort Analysis. Orthopaedic Journal of Sports Medicine. 2026. DOI: 10.1177/23259671251412408

[12] Glucagon-Like Peptide-1 Receptor Agonist Use Is Not Associated With Increased Complications After Total Hip Arthroplasty in Patients Who Have Type 2 Diabetes. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2024.10.099

[13] Poster 6: GLP-1 Receptor Agonist Use Is Not Associated With an Increased Risk of Complications After Anatomic Total Shoulder Arthroplasty. Orthopaedic Journal of Sports Medicine. 2025. DOI: 10.1177/2325967125s00120

[14] Glucagon-like peptide-1 receptor agonists in total joint arthroplasty: a comprehensive systematic review of what orthopaedic surgeons should know. Arthroplasty. 2026. DOI: 10.1186/s42836-026-00375-w

[15] Does use of glucagon-like peptide-1 agonists increase perioperative complications in patients undergoing shoulder arthroplasty?. Journal of Shoulder and Elbow Surgery. 2025. DOI: 10.1016/j.jse.2024.07.045

[16] Effect of Glucagon-Like Peptide-1 Receptor Agonist Use on Fusion Outcomes After First Metatarsophalangeal Arthrodesis in Patients With Type 2 Diabetes Mellitus. Journal of the American Academy of Orthopaedic Surgeons. 2026. DOI: 10.5435/jaaos-d-26-00153

[17] The Impact of Glucagon-Like Peptide-1 Receptor Agonist Use on Clinical Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis of 346,899 Patients. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.09.054

[18] Impact of Glucagon-Like Peptide-1 Receptor Agonists on Postoperative Outcomes in Arthroplasty: A Systematic Review. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.07.015

[19] Short-Term Complications of Preoperative Weight Loss Strategies in Total Knee Arthroplasty: Bariatric Surgery Versus Glucagon-Like Peptide-1 Receptor Agonists. The Journal of Arthroplasty. 2026. DOI: 10.1016/j.arth.2025.08.073

[20] Trends, Demographics, and Outcomes for Glucagon-Like Peptide-1 Receptor Agonist Use in Total Knee Arthroplasty: An 11-Year Perspective. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.02.042

[21] Preoperative GLP-1 Agonist Use Is Associated with Decreased Complications Compared to Bariatric Surgery Following Primary Total Hip Arthroplasty. The Journal of Arthroplasty. 2026. DOI: 10.1016/j.arth.2026.04.032

[22] Utilization of Glucagon-Like Peptide-1 Receptor Agonist at the Time of Total Hip Arthroplasty for Patients Who Have Morbid Obesity. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2024.12.008

[23] Glucagon-like peptide-1 Agonists and Common Hand Procedures: Perioperative and Postoperative Risks and Complications. The Journal of Hand Surgery. 2025. DOI: 10.1016/j.jhsa.2025.08.004

[24] Semaglutide and Other GLP-1 Agonists: A Boon for the Arthroplasty Industry?. The Journal of Arthroplasty. 2024. DOI: 10.1016/j.arth.2023.12.014

[25] Glucagon-like peptide-1 receptor agonist use is associated with increased risk of perioperative complication and readmission following shoulder arthroplasty. Journal of Shoulder and Elbow Surgery. 2025. DOI: 10.1016/j.jse.2024.09.012

[26] Decreased Risk of Readmission and Complications With Preoperative GLP-1 Analog Use in Patients Undergoing Primary Total Joint Arthroplasty. The Journal of Arthroplasty. 2024. DOI: 10.1016/j.arth.2024.05.079

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b. TO THE EXTENT POSSIBLE, IN NO EVENT WILL THE LICENSOR BE LIABLE TO YOU ON ANY LEGAL THEORY (INCLUDING, WITHOUT LIMITATION, NEGLIGENCE) OR OTHERWISE FOR ANY DIRECT, SPECIAL, INDIRECT, INCIDENTAL, CONSEQUENTIAL, PUNITIVE, EXEMPLARY, OR OTHER LOSSES, COSTS, EXPENSES, OR DAMAGES ARISING OUT OF THIS PUBLIC LICENSE OR USE OF THE LICENSED MATERIAL, EVEN IF THE LICENSOR HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH LOSSES, COSTS, EXPENSES, OR DAMAGES. WHERE A LIMITATION OF LIABILITY IS NOT ALLOWED IN FULL OR IN PART, THIS LIMITATION MAY NOT APPLY TO YOU.

c. The disclaimer of warranties and limitation of liability provided above shall be interpreted in a manner that, to the extent possible, most closely approximates an absolute disclaimer and waiver of all liability.

Section 6 -- Term and Termination.

a. This Public License applies for the term of the Copyright and Similar Rights licensed here. However, if You fail to comply with this Public License, then Your rights under this Public License terminate automatically.

b. Where Your right to use the Licensed Material has terminated under Section 6(a), it reinstates:

1. automatically as of the date the violation is cured, provided it is cured within 30 days of Your discovery of the violation; or

2. upon express reinstatement by the Licensor.

For the avoidance of doubt, this Section 6(b) does not affect any right the Licensor may have to seek remedies for Your violations of this Public License.

c. For the avoidance of doubt, the Licensor may also offer the Licensed Material under separate terms or conditions or stop distributing the Licensed Material at any time; however, doing so will not terminate this Public License.

d. Sections 1, 5, 6, 7, and 8 survive termination of this Public License.

Section 7 -- Other Terms and Conditions.

a. The Licensor shall not be bound by any additional or different terms or conditions communicated by You unless expressly agreed.

b. Any arrangements, understandings, or agreements regarding the Licensed Material not stated herein are separate from and independent of the terms and conditions of this Public License.

Section 8 -- Interpretation.

a. For the avoidance of doubt, this Public License does not, and shall not be interpreted to, reduce, limit, restrict, or impose conditions on any use of the Licensed Material that could lawfully be made without permission under this Public License.

b. To the extent possible, if any provision of this Public License is deemed unenforceable, it shall be automatically reformed to the minimum extent necessary to make it enforceable. If the provision cannot be reformed, it shall be severed from this Public License without affecting the enforceability of the remaining terms and conditions.

c. No term or condition of this Public License will be waived and no failure to comply consented to unless expressly agreed to by the Licensor.

d. Nothing in this Public License constitutes or may be interpreted as a limitation upon, or waiver of, any privileges and immunities that apply to the Licensor or You, including from the legal processes of any jurisdiction or authority.


Creative Commons is not a party to its public licenses. Notwithstanding, Creative Commons may elect to apply one of its public licenses to material it publishes and in those instances will be considered the “Licensor.” The text of the Creative Commons public licenses is dedicated to the public domain under the CC0 Public Domain Dedication. Except for the limited purpose of indicating that material is shared under a Creative Commons public license or as otherwise permitted by the Creative Commons policies published at creativecommons.org/policies, Creative Commons does not authorize the use of the trademark "Creative Commons" or any other trademark or logo of Creative Commons without its prior written consent including, without limitation, in connection with any unauthorized modifications to any of its public licenses or any other arrangements, understandings, or agreements concerning use of licensed material. For the avoidance of doubt, this paragraph does not form part of the public licenses.

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