Clinicians › Hand
Paronychia (Infection Beside the Nail)

For patients: a plain-language version of this topic is available. See the patient guide.
Overview¶
Paronychia is an infection of the nail fold, with Staphylococcus pyogenes and Candida albicans frequently cultured from affected tissue in chronic cases [1]. While fungal infections of the hand most commonly present as cutaneous involvement of the skin and nails [12], the role of Candida in chronic paronychia is distinct; eradication of Candida is not associated with clinical cure in most patients, indicating it acts primarily as a colonizer of the proximal nail fold rather than a primary pathogen [7]. Although infections caused by Candida parapsilosis alone respond well to terbinafine, this agent is not as effective in candidal nail disease overall [14]. Chronic keratinaceous paronychia should be regarded as a potential complication of nail biting [3].
Complicated paronychia and hand infections are more frequent than expected, occurring in 33% of cases, and are often iatrogenic [4]. Surgical correction is indicated for nail deformities caused by congenital anomalies, tumors, and infection, which can frequently be corrected or improved surgically [9]. However, outcomes are less favorable when associated with specific injury patterns; poorer results occurred with crush or avulsion injuries, injuries of both the nail bed and nail fold, and with associated infection [38].
Anatomy & Pathophysiology¶
Definition and Etiology¶
Paronychia is defined as an inflammation of the tissue surrounding the nail plate [23] and constitutes a localized, superficial infection or abscess of the paronychial tissues of the hands or, less commonly, the feet [44]. Acute paronychia resembles acute cellulitis at other sites and is usually of streptococcal or staphylococcal origin arising from a "hangnail" or trauma [23]. The most commonly cultured organism in acute paronychia is Staphylococcus aureus [44]. In contrast, Candida species are responsible for chronic or recurrent paronychia, a condition more prevalent in women working in moist environments and those patients who work under water [28]. Chronic paronychia is most commonly an environmental disease resulting from an impairment of the epidermal barrier of the proximal nail fold [24]. The first step in its development is always a mechanical or chemical trauma that produces cuticle damage [24]. Cuticle injury can result from manicuring, occupational trauma, frequent handwashing, continuous exposure to water, and/or irritative compounds [24]. When the cuticle is damaged or lost, the epidermal barrier of the proximal nail fold is destroyed and the proximal nail fold is exposed to environmental hazards [24]. Irritants and allergens may then penetrate the proximal nail fold to produce an inflammatory reaction of the nail fold and nail matrix [24]. This inflammatory reaction interferes with normal nail growth and the formation of a new cuticle [24]. Chronic paronychia should no longer be considered a mycotic disease but an eczematous condition with multifactorial etiology [15]. Accumulating evidence indicates that in most cases chronic paronychia represents a clinical variety of contact urticaria [24].
Anatomical Pathophysiology¶
Chronic paronychia comprises two basic components: a pocket which holds moisture and allows the survival of many different organisms, and an anatomic deformity of rounding out and retraction of the posterior nail fold [23]. This anatomic deformity is caused by foreign material in the dermis [23]. The resulting dermal change with subsequent rounding out and retraction assures the continuing presence of the moisture-holding pocket [23]. Maceration of the posterior nail fold allows the passage of foreign material into the dermis of the fold and incites a chronic inflammatory reaction [34]. Sterile maceration did not produce the changes of chronic paronychia when prolonged for three to six months [34]. The addition of hemolytic streptococci, Proteus mirabilis, Proteus morganii, E. coli, and Pseudomonas aeruginosa to occluded nail folds seemed to speed maceration, but the final lesion produced did not differ significantly from those resulting from simple maceration [34]. Conversely, the retraction and rounding out phenomenon was repeatedly reproduced when C. albicans was added to the fold and occluded for 30 days [34]. Candida albicans may contribute to the development of the lesion by destroying the epidermal barrier rather than by supplying the foreign material [34]. Monilia contribute to the disease process by irritation on the surface and by penetration of debris into the dermis [23]. Debris stimulates chronic inflammation which in turn often aggravates the original defect [23].
Clinical Presentation and Demographics¶
Chronic paronychia almost exclusively affects adult women [24]. Paronychia is more common in women than in men, with a female-to-male ratio of 3:1 [44]. In adults, chronic paronychia is very gradual in onset and often begins with a swelling and separation of the lateral nail fold from the side of the nail [23]. Some adults will have only one side of the posterior nail fold involved after the lesion has been present for several years [23]. In children, chronic paronychia lesions are generally prominent, with total involvement of the posterior nail fold [23]. In children, the lesion appears as a marked rounding out and retraction of the posterior nail fold, and thick pustular material can often be expressed from the pocket under that fold [23]. Thumb-sucking is the most frequent predisposing factor of chronic paronychia in children [23]. Chronic paronychia is clinically characterized by a chronic inflammation of the proximal nail fold with or without nail plate abnormalities [24]. The condition usually has a prolonged course interspersed with recurrent self-limited episodes of acute exacerbations [24]. If paronychia is neglected, pus may spread under the nail sulcus to the opposite side, resulting in a "run-around abscess" [44]. Pus may also accumulate beneath the nail itself and lift the plate off the underlying matrix [44]. Immunosuppressive states and systemic diseases such as diabetes can alter the causative organisms and the intensity of treatment required [44].
Classification¶
Paronychia is classified primarily by clinical presentation and etiology rather than a single standardized grading system. The condition is divided into acute and chronic forms, each with distinct pathophysiological origins and clinical features.
Acute Paronychia: Acute paronychia is clinically similar to acute cellulitis at other sites and is usually of streptococcal or staphylococcal origin [23]. It typically arises from a "hangnail" or trauma [23]. It is rare for an acute lesion to be followed by a chronic paronychia [23].
Chronic Paronychia: Chronic paronychia is characterized by a chronic inflammation of the proximal nail fold with or without nail plate abnormalities [24]. In adults, the onset is very gradual and often begins with swelling and separation of the lateral nail fold from the side of the nail [23]. In children, the lesion appears as marked rounding out and retraction of the posterior nail fold [23]. The underlying cause is generally agreed to be prolonged exposure to cold water, allowing Candida and Pseudomonas species to act as opportunist pathogens [27]. However, mechanisms of infection, trauma, and prolonged immersion of the hands in water are not sufficient to explain the chronic forms of the disease [16]. Candida eradication was not associated with clinical cure in most patients, indicating that Candida is just a colonizer of the proximal nail fold [7].
Etiology and Predisposing Factors: The first step in the development of chronic paronychia is mechanical or chemical trauma that produces cuticle damage [24]. Cuticle injury can result from manicuring, occupational trauma, frequent handwashing, or continuous exposure to water and irritative compounds [24]. Consequently, chronic paronychia is most commonly an environmental disease resulting from an impairment of the epidermal barrier of the proximal nail fold [24]. Thumb-sucking is the most frequent predisposing factor for chronic paronychia in children [23]. Chronic paronychia should be regarded as a potential complication of nail biting [3]. Chronic keratinaceous paronychia is a distinct entity associated with nail biting [3].
Pathophysiology and Complications: The dermal change with subsequent rounding out and retraction assures the continuing presence of the pocket in chronic paronychia [23]. Chronic monilial disease usually localizes at sites of pre-existing defects [23]. The debris from monilial infection stimulates chronic inflammation which often aggravates the original defect [23]. Complicated paronychia and hand infections are more frequent than expected, occurring in 33% of cases [4]. These complicated infections are often iatrogenic [4].
Clinical Presentation¶
Paronychia is a common inflammatory condition of the nail fold often associated with infection [68]. Etiologies include fungal, viral, or most commonly bacterial causes [68]. Neonatal paronychia is a rare presentation, with only one previously reported case in the literature involving a patient younger than 1 month of age [68].
Acute Paronychia¶
Acute paronychia usually arises from a "hangnail" or trauma and is of streptococcal or staphylococcal origin [23]. The typical presentation involves a tender, swollen, and erythematous eponychium with a purulent collection under the nailfold but not under the nail plate itself [22]. Erythema does not extend proximal to the distal interphalangeal joint [22]. Radiographs are normal except for soft tissue swelling dorsally in the region of the infection [22].
Chronic Paronychia¶
Chronic paronychia presents with erythema, swelling, and pain, although the degree of erythema and swelling is often less than that associated with acute paronychia [32]. Symptoms are generally present for 6 weeks at the time of diagnosis [32]. Episodic exacerbations may occur, often following exposure to moist environments [32]. The proximal nail fold may become raised and separated from the underlying nail [32]. Associated nail changes include ridging, grooving, discoloration, and/or rounding of the nail plate [32].
In children, the lesion appears as marked rounding out and retraction of the posterior nail fold, with thick pustular material often expressible from the pocket under that fold [23]. Cuticle injury can result from manicuring, occupational trauma, frequent handwashing, or continuous exposure to water and/or irritative compounds [24]. The mechanisms of infection, trauma, and prolonged immersion of the hands in water are not sufficient to explain the chronic forms of the disease [16].
Two basic components characterize chronic paronychia: a pocket which holds moisture and allows the survival of many different organisms, and an anatomic deformity of rounding out and retraction of the posterior nail fold due to foreign material in the dermis [23]. The dermal change with subsequent rounding out and retraction assures the continuing presence of the pocket [23]. This debris stimulates chronic inflammation, which in turn often aggravates the original defect [23]. Strong and weak concentrations of primary irritants produced erythema and ridging of the nail without the rounding out of the fold [34]. The addition of hemolytic streptococci, Proteus mirabilis, Proteus morganii, E. coli, and Pseudomonas aeruginosa to occluded nail folds seemed to speed maceration, but the final lesion produced did not differ significantly from those resulting from simple maceration [34].
All patients in a study of chronic paronychia had a positive culture for C. albicans from the nail fold before biopsy [67]. Cultures from the dermis of the paronychia were all negative, and there was no yeast growth on any of the bacterial cultures taken from these areas [67]. Chronic paronychia responds slowly to treatment and may take several weeks or months [15]. If untreated, painful episodes of acute inflammation may be experienced as a result of continuous penetration of various pathogens [15].
Atypical and Complicated Presentations¶
Further diagnostic testing may be warranted in atypical cases of chronic paronychia in which malignancy or systemic etiologies are suspected [32]. The clinical differential diagnosis of a new periungual or subungual lesion (with or without an associated nail plate dystrophy) should include tumor metastasis to the nail unit not only in oncology patients, but also in previously cancer-free individuals [13]. Physicians should consider squamous cell carcinoma of the nail unit in each case of a nail abnormality unresponsive to topical treatment [37]. A patient with Kaposi's sarcoma in the hand of an AIDS patient presented with what appeared to be a chronic paronychia [35].
Complicated paronychia and hand infections are more frequent than expected (33% of cases) and often iatrogenic [4]. The combination of persistent, active inflammation, compromised vasculature, poor hand hygiene, poor healing and a reluctance to seek treatment may allow paronychia to evolve and erode into the joint space [19]. Atypical hand infections are difficult to recognize and treat due to their indolent nature and nonspecific symptoms [83].
Investigations¶
Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis [47].
Plain radiography: Radiographs are typically normal, except for some soft tissue swelling dorsally in the region described in a case of acute paronychia [22]. Early osteomyelitis of the bone can be detected long before the roentgenogram reveals evidences of destruction [117]. In a case of metastatic bronchogenic carcinoma masquerading as a felon, the diagnostic consideration of neoplasm was entertained only after cortical destruction was present on later roentgenographs [118].
Other Considerations: Physicians should consider SCCNU in each case of a nail abnormality unresponsive to topical treatment [37].
Treatment¶
Non-Operative¶
Conservative management is the primary approach for acute paronychia in the absence of pus under the nail or in the nailfold, typically involving oral anti-staphylococcal antibiotics with or without warm saline soaks [22]. Advocates of warm soaks posit that heat encourages the spontaneous drainage of occult pus [22]. For early paronychia, a conservative method of lifting the cuticle and inserting a sterile rubber ribbon can arrest and cure the condition in a few days without nail removal [39]. Chemical sealing using cyanoacrylate glue heals the gap between the proximal nail fold and nail plate within 6–8 weeks, providing relief from chronic paronychia [6].
Chronic paronychia requires preventive measures as the main part of therapy [15]. Topical steroids play a major role in therapy and are more effective than systemic anti-fungals (level of evidence B) [15]. Tacrolimus has recently shown promising results in the treatment of chronic paronychia [15]. Fungal infections of the hand can be treated with topical or local therapy [12]. In a small number of patients treated for chronic paronychia, all improved at the same rate, probably because the care of the nail folds is more important than the medication applied [21].
Specific pharmacological and physical agents have demonstrated efficacy. Nineteen of 29 patients (65.5%) in Cohort B reported moderately or very painful nails at baseline that decreased to five patients (17.2%) at visit 3 in a trial of a novel topical povidone-iodine formulation [8]. Chronic paronychia required on average 20.4 ± 18.32 days of therapy to reach the treatment endpoint using low-level laser therapy [18]. Fifty-nine patients with proved monilial paronychia were treated with the nail polish sealer method [20]. Additionally, 50 mg/day fluconazole is both effective and safe in the management of chronic paronychia [36].
Operative¶
Indications: Surgical therapy should be resorted to in recalcitrant cases of chronic paronychia [15]. The author believes that a simple procedure should be tried first in almost every case, as many patients may be cured without recourse to nail removal [10]. En bloc excision of the proximal nail fold is a useful method in recalcitrant chronic paronychia [2]. The square flap technique was employed for exuberant chronic paronychia with involvement of all digits and an unsatisfactory response to clinical therapies [71].
Surgical Approach / Technique: In cases of complicated paronychia, thorough excision is essential [30]. The Swiss roll technique is a simple method for the treatment of chronic and severe acute paronychia with run around infection involving both nail folds [26]. The square flap technique cured paronychia in all but 2 cases, measured by cuticle regrowth [31]. A single case of severe paronychia was treated by burning holes through the nail with a heated wire to drain pus, resulting in instant relief and the patient returning to full duty by the fifth morning [5].
Adjuncts: Simultaneous nail removal augments the results in most cases of chronic paronychia [15]. Nail removal should be performed when concurrent nail irregularities are seen in the surgical treatment of chronic paronychia [17]. In a prospective study of 46 patients with acute felon and paronychia, antibiotics were not necessary after surgical treatment [43]. Conversely, empirical antibiotic therapy with amoxicillin–clavulanic acid is appropriate in cases of complicated paronychia [30].
Other Considerations: The study reports on 26 patients treated for paronychia granulomatosa [111].
Complications¶
General Infection Risks: Hand infections carry a high rate of complications that are often difficult to manage [102]. If chronic paronychia remains untreated, continuous penetration of various pathogens results in painful episodes of acute inflammation [15].
Joint Erosion: In patients with thromboangiitis obliterans, atypical chronic sterile paronychia can evolve and erode into the joint space [19]. This progression may occur when persistent active inflammation, compromised vasculature, poor hand hygiene, poor healing, and reluctance to seek treatment combine to allow the infection to invade the joint [19].
Chronic Morphological Changes: In children, chronic paronychia is characterized by total involvement of the posterior nail fold, marked rounding out and retraction of the posterior nail fold, and thick pustular material expressed from the pocket under that fold [23]. In adults, the condition often begins with swelling and separation of the lateral nail fold from the side of the nail, with some patients having only one side of the posterior nail fold involved after the lesion has been present for several years [23]. The proximal nail fold may become raised and separated from the underlying nail [32].
Nail Plate and Cuticle Alterations: Chronic paronychia is characterized by a chronically indurated and rounded or bolstered cuticle, recurring episodes of increased inflammation, drainage, and eventual thickening and longitudinal grooving of the nail plate [80].
Other Considerations: Candida and nondermatophyte infections often involve the surrounding nail folds, causing paronychia in addition to nail plate disease [33].
Recovery¶
Non-Operative Management: A simple procedure should be tried first in almost every case, as many patients may be cured without recourse to nail removal [10]. In the treatment of chronic paronychia, the care of the nail folds is more important than the medication applied [21]. When treated with low-level laser therapy (LLLT), chronic paronychia required on average 20.4 ± 18.32 days of therapy to reach the treatment endpoint [18]. Following chemical sealing with cyanoacrylate glue, the gap between the proximal nail fold and nail plate heals and fills up within 6–8 weeks, providing relief from chronic paronychia [6]. Regarding pain reduction, nineteen of 29 patients (65.5%) in Cohort B reported moderately or very painful nails at baseline that decreased to five patients (17.2%) at visit 3 following treatment with a novel topical povidone-iodine formulation [8].
Operative Management: During surgical treatment of paronychia, tissues appearing infected are widely excised while preserving as much of the nail matrix as possible [43]. Antibiotics are not necessary after surgical treatment for acute felon and paronychia in patients without complications or at-risk conditions [43]. In a single case of severe paronychia, the condition was treated by burning holes through the nail with a heated wire to drain pus, resulting in instant relief and the patient returning to full duty by the fifth morning [5].
Complications and Prognosis: Nail-bed injuries are often neglected and can result in a painful deformed nail that diminishes the function of the finger in pinch and other activities [29].
Key Evidence¶
- [L5] The paper reviews the aetiology and treatment of chronic paronychia, noting that Staphylococcus pyogenes and Candida albicans are frequently cultured from infected nail folds. [1] (10.1136/bmj.4.5730.257)
- [L2] En bloc excision of the proximal nail fold is a useful method in recalcitrant chronic paronychia. [2] (10.1111/j.1524-4725.2006.32079.x)
- [L5] Chronic keratinaceous paronychia should be regarded as a potential complication of nail biting. [3] (10.1136/bmj.280.6208.189-g)
- [L4] Complicated paronychia and hand infections are more frequent than expected (33% of cases) and often iatrogenic. [4] (10.1016/j.hansur.2019.10.076)
- [L5] The author reports a single case of severe paronychia treated by burning holes through the nail with a heated wire to drain pus, resulting in instant relief and the patient returning to full duty by the fifth morning. [5] (10.1136/bmj.2.4417.299-a)
- [L4] The gap between the proximal nail fold and nail plate heals and fills up within 6–8 weeks, providing relief from chronic paronychia. [6] (10.25259/csdm_132_2023)
- [L1] Candida eradication was not associated with clinical cure in most patients, indicating that Candida is just a colonizer of the proximal nail fold. [7] (10.1067/mjd.2002.122191)
- [L2] Nineteen of 29 patients (65.5%) in Cohort B reported moderately or very painful nails at baseline that decreased to five patients (17.2%) at visit 3. [8] (10.1007/s10637-019-00825-0)
- [Paper] Congenital anomalies, tumors, and infection can also cause nail deformities and can frequently be corrected or improved surgically. [9] (10.1016/s0894-1130(00)80018-6)
- [L5] The author believes that this simple procedure should be tried first in almost every case, as many patients may be cured without recourse to nail removal. [10] (10.1056/nejm193412062112313)
- [L5] Fungal infections of the hand are most commonly cutaneous infections involving the skin and nails and can be treated with topical or local therapy. [12] (10.1016/j.hcl.2020.03.009)
- [L4] The clinical differential diagnosis of a new periungual or subungual lesion (with or without an associated nail plate dystrophy) should include tumor metastasis to the nail unit not only in oncology patients, but also in previously cancer-free individuals. [13] (10.1097/00042728-200103000-00014)
- [L1] Infections caused by Candida parapsilosis alone responded well, but terbinafine is not as effective in candidal nail disease overall. [14] (10.3109/09546639209088701)
- [L4] [15] (10.4103/0019-5154.123482)
- [L4] The author describes the principal clinical characteristics of paronychia and reviews its pathogenesis, stressing the fact that the mechanisms of infection, trauma and prolonged immersion of the hands in water, are not sufficient to explain the chronic forms of the disease. [16] (10.1159/000255443)
- [L4] Nail removal should be performed when concurrent nail irregularities are seen. [17] (10.1016/s0363-5023(10)80118-2)
- [L4] Chronic paronychia required on average 20.4 ± 18.32 days of therapy to reach the treatment endpoint. [18] (10.5978/islsm.10.133)
- [L5] The combination of persistent, active inflammation, compromised vasculature, poor hand hygiene, poor healing and a reluctance to seek treatment may well have allowed the paronychia to evolve and erode into the joint space. [19] (10.1111/j.1440-0960.2012.00967.x)
- [L4] Fifty-nine patients with proved monilial paronychia were treated with the nail polish sealer method. [20] (10.1001/archderm.1955.03730340045008)
- [L4] Although a small number of patients were treated, they all improved at the same rate; probably because the care of the nail folds is more important than the medication applied. [21] (10.1097/00043764-196606000-00039)
- [L5] [22] (10.1016/j.jhsa.2011.11.021)
- [L4] [23] (10.1177/000992286800700213)
- [L5] [24] (10.5070/d32wb4g9wf)
- [L4] The Swiss roll technique is a simple method for the treatment of chronic and severe acute paronychia with run around infection involving both nail folds. [26] (10.1097/bth.0b013e3181ec089e)
- [L5] The underlying cause of chronic paronychia is generally agreed to be prolonged exposure to (cold) water, allowing Candida and Pseudomonas species to act as opportunist pathogens. [27] (10.1136/bmj.2.6200.1294-a)
- [L5] [28] (10.1302/2058-5241.4.180082)
- [L5] Nail-bed injuries are often neglected and can result in a painful deformed nail that diminishes the function of the finger in pinch and other activities. [29] (10.1097/00130911-200206000-00002)
- [L4] In cases of complicated paronychia, thorough excision is essential and empirical antibiotic therapy with amoxicillin–clavulanic acid is appropriate. [30] (10.1016/j.hansur.2025.102235)
- [L4] The novel method cured paronychia in all but 2 cases, measured by cuticle regrowth. [31] (10.1016/j.jaad.2016.02.1154)
- [L5] [32] (10.5435/jaaos-22-03-165)
- [L5] [33] (10.1016/j.jhsa.2013.11.017)
- [L4] [34] (10.1001/archderm.1964.01590270141032)
- [L5] The patient had what appeared to be a chronic paronychia. [35] (10.1016/s0363-5023(86)80151-4)
- [L4] These results show that 50 mg/day fluconazole is both effective and safe in the management of chronic paronychia. [36] (10.3109/09546639909056029)
- [L4] Physicians should consider SCCNU in each case of a nail abnormality unresponsive to topical treatment. [37] (10.1016/j.jhsa.2018.01.010)
- [L4] Poorer results occurred with crush or avulsion injuries, with injuries of both nail bed and nail fold, and with associated infection. [38] (10.1016/s0363-5023(84)80153-7)
- [L5] Early paronychia can be arrested and cured in a few days without the necessity of nail removal through a conservative method of lifting the cuticle and inserting a sterile rubber ribbon. [39] (10.1056/nejm192511051931904)
- [L2] [43] (10.1016/j.hansur.2015.12.003)
- [L4] [44] (10.1097/01.bth.0000163575.00615.69)
- [L5] Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis. [47] (10.1016/j.hcl.2020.03.002)
- [L4] [67] (10.1001/archderm.1962.01590090066015)
- [L5] [68] (10.1111/pde.15017)
- [L5] [71] (10.5935/scd1984-8773.2026180505)
- [L4] [80] (10.1097/00006534-197607000-00011)
- [L4] Atypical hand infections are difficult to recognize and treat due to their indolent nature and nonspecific symptoms; early identification through appropriate laboratory testing and surgical treatment paired with medical management is imperative for eradication of the causative organism. [83] (10.1016/j.jhsa.2025.09.023)
- [L5] Hand infections are associated with a high rate of complications that are often difficult to manage. [102] (10.1016/j.hcl.2020.03.010)
- [L4] The study reports on 26 patients treated for paronychia granulomatosa. [111] (10.2340/000155555319320)
- [L4] Early osteomyelitis of the bone can be detected long before the roentgenogram reveals evidences of destruction. [117] (10.1097/00000658-194001000-00013)
- [L5] Only after cortical destruction was present on later roentgenographs was the diagnostic consideration of neoplasm entertained. [118] (10.1016/s0363-5023(83)80171-3)
See Also¶
References¶
[1] Problems of chronic paronychia.. BMJ. 1970. DOI: 10.1136/bmj.4.5730.257
[2] En Bloc Excision of Proximal Nail Fold for Treatment of Chronic Paronychia. Dermatologic Surgery. 2006. DOI: 10.1111/j.1524-4725.2006.32079.x
[3] Points: Treatment of chronic paronychia. BMJ. 1980. DOI: 10.1136/bmj.280.6208.189-g
[4] Les panaris compliqués d’emblée : plus fréquents qu’attendus et souvent iatrogènes. Hand Surgery and Rehabilitation. 2019. DOI: 10.1016/j.hansur.2019.10.076
[5] Treatment of Severe Paronychia. BMJ. 1945. DOI: 10.1136/bmj.2.4417.299-a
[6] Chemical sealing of proximal nail fold with cyanoacrylate glue for accelerated regeneration of nail cuticle as a treatment of chronic paronychia. Cosmoderma. 2023. DOI: 10.25259/csdm_132_2023
[7] Topical steroids versus systemic antifungals in the treatment of chronic paronychia: An open, randomized double-blind and double dummy study. Journal of the American Academy of Dermatology. 2002. DOI: 10.1067/mjd.2002.122191
[8] A randomized phase 2 trial of the efficacy and safety of a novel topical povidone-iodine formulation for Cancer therapy-associated Paronychia. Investigational New Drugs. 2019. DOI: 10.1007/s10637-019-00825-0
[9] Understanding the perionychium. Journal of Hand Therapy. 2000. DOI: 10.1016/s0894-1130(00)80018-6
[10] Note on the Treatment of Paronychia. New England Journal of Medicine. 1934. DOI: 10.1056/nejm193412062112313
[12] Fungal Infections of the Hand. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.009
[13] Metastatic Tumors to the Nail Unit. Dermatologic Surgery. 2001. DOI: 10.1097/00042728-200103000-00014
[14] Terbinafine in chronic paronychia and candida onychomycosis. Journal of Dermatological Treatment. 1992. DOI: 10.3109/09546639209088701
[15] Management of chronic paronychia. Indian Journal of Dermatology. 2014. DOI: 10.4103/0019-5154.123482
[16] Pathogenesis and Treatment of Chronic Paronychia. Dermatologica. 2009. DOI: 10.1159/000255443
[17] Eponychial marsupialization and nail removal for surgical treatment of chronic paronychia. The Journal of Hand Surgery. 1991. DOI: 10.1016/s0363-5023(10)80118-2
[18] TREATMENT OF NAIL DISORDERS WITH LLLT (2) CHRONIC PARONYCHIA AND INGROWN NAIL. LASER THERAPY. 1998. DOI: 10.5978/islsm.10.133
[19] Atypical chronic sterile paronychia leading to tissue and joint space destruction in a patient with thromboangiitis obliterans. Australasian Journal of Dermatology. 2012. DOI: 10.1111/j.1440-0960.2012.00967.x
[20] USE OF NAIL POLISH SEALER IN TREATMENT OF MONILIAL PARONYCHIA. Archives of Dermatology. 1955. DOI: 10.1001/archderm.1955.03730340045008
[21] The Treatment of Chronic Paronychia. Journal of Occupational and Environmental Medicine. 1966. DOI: 10.1097/00043764-196606000-00039
[22] Acute Paronychia. The Journal of Hand Surgery. 2012. DOI: 10.1016/j.jhsa.2011.11.021
[23] Chronic Paronychia in Children. Clinical Pediatrics. 1968. DOI: 10.1177/000992286800700213
[24] Controversy: the role of yeasts in chronic paronychia: pro. Dermatology Online Journal. 2003. DOI: 10.5070/d32wb4g9wf
[26] Swiss Roll Technique for Treatment of Paronychia. Techniques in Hand & Upper Extremity Surgery. 2011. DOI: 10.1097/bth.0b013e3181ec089e
[27] Treatment of chronic paronychia. BMJ. 1979. DOI: 10.1136/bmj.2.6200.1294-a
[28] Infections of the hand: an overview. EFORT Open Reviews. 2019. DOI: 10.1302/2058-5241.4.180082
[29] Nail-Bed Repair and Reconstruction. Techniques in Hand and Upper Extremity Surgery. 2002. DOI: 10.1097/00130911-200206000-00002
[30] Epidemiology and management of purulent paronychia: A bicentric study. Hand Surgery and Rehabilitation. 2025. DOI: 10.1016/j.hansur.2025.102235
[31] Chronic paronychia treatment: Square flap technique. Journal of the American Academy of Dermatology. 2016. DOI: 10.1016/j.jaad.2016.02.1154
[32] Acute and Chronic Paronychia of the Hand. Journal of the American Academy of Orthopaedic Surgeons. 2014. DOI: 10.5435/jaaos-22-03-165
[33] Fungal Nail Infections. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2013.11.017
[34] Experimental Studies on Chronic Paronychia. Archives of Dermatology. 1964. DOI: 10.1001/archderm.1964.01590270141032
[35] Kaposi's sarcoma in the hand of an AIDS patient. The Journal of Hand Surgery. 1986. DOI: 10.1016/s0363-5023(86)80151-4
[36] Fluconazole 50 mg/day therapy in the management of chronic paronychia. Journal of Dermatological Treatment. 1999. DOI: 10.3109/09546639909056029
[37] Squamous Cell Carcinoma of the Nail Unit: Review of the Literature. The Journal of Hand Surgery. 2018. DOI: 10.1016/j.jhsa.2018.01.010
[38] A study of nail bed injuries: Causes, treatment, and prognosis. The Journal of Hand Surgery. 1984. DOI: 10.1016/s0363-5023(84)80153-7
[39] The Treatment of Early Paronychia. The Boston Medical and Surgical Journal. 1925. DOI: 10.1056/nejm192511051931904
[43] Acute felon and paronychia: Antibiotics not necessary after surgical treatment. Prospective study of 46 patients. Hand Surgery and Rehabilitation. 2016. DOI: 10.1016/j.hansur.2015.12.003
[44] DAREJD Simple Technique of Draining Acute Paronychia. Techniques in Hand & Upper Extremity Surgery. 2005. DOI: 10.1097/01.bth.0000163575.00615.69
[47] Imaging and Laboratory Workup for Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.002
[67] Chronic Paronychia. Archives of Dermatology. 1962. DOI: 10.1001/archderm.1962.01590090066015
[68] Acute paronychia in a neonate secondary to clindamycin‐resistant Staphylococcus aureus. Pediatric Dermatology. 2022. DOI: 10.1111/pde.15017
[71] Exuberant chronic paronychia: a surgical approach using the square flap technique. Surgical & Cosmetic Dermatology. 2026. DOI: 10.5935/scd1984-8773.2026180505
[80] SURGICAL CURE OF CHRONIC PARONYCHIA BY EPONYCHIAL MARSUPIALIZATION. Plastic and Reconstructive Surgery. 1976. DOI: 10.1097/00006534-197607000-00011
[83] Atypical Hand Infections. The Journal of Hand Surgery. 2026. DOI: 10.1016/j.jhsa.2025.09.023
[102] Complications of Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.010
[111] Surgical treatment of paronychia granulomatosa hallucis. Acta Dermato-Venereologica. 1975. DOI: 10.2340/000155555319320
[117] NEW INCISION FOR CLOSED SPACE INFECTION (FELON) INVOLVING DISTAL PHALANX OF FINGER. Annals of Surgery. 1940. DOI: 10.1097/00000658-194001000-00013
[118] Metastatic bronchogenic carcinoma masquerading as a felon. The Journal of Hand Surgery. 1983. DOI: 10.1016/s0363-5023(83)80171-3