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Infected Flexor Sheath (Pyogenic Flexor Tenosynovitis)

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Overview¶
Pyogenic flexor tenosynovitis is a closed-space infection of the finger or thumb flexor tendon sheath or the radial and ulnar bursae [9]. Although described as uncommon [3], it is a relatively common but often misdiagnosed hand infection [6]. The condition may present with uniform finger swelling, though this finding does not appear to distinguish pyogenic flexor tenosynovitis from other finger infections [10]. Ultrasound serves as a useful diagnostic tool for managing early cases due to its excellent negative predictive value and specificity [8].
The consequences of untreated or delayed management include destruction of the tendon sheath, scarring, inflammation causing oedema of the soft tissues of the finger with resultant finger stiffness, or occasionally compartment syndrome [13]. Even in otherwise healthy patients who receive aggressive and prompt antibiotic therapy and surgical intervention, some residual digital stiffness is expected following flexor tendon sheath infection [4]. The presence of pus within the flexor sheath is the only significant predictive factor for repeated flexor tendon washout [15].
Surgical decompression is the treatment of choice for nearly all cases of septic flexor tenosynovitis, with expediency potentially improving final motion and function [2]. Studies demonstrate benefits of early treatment and systemic antibiotic use [5]. Early diagnosis followed by drainage through small incisions and continuous postoperative irrigation appears to lead to the best functional outcome [18]. A single open debridement with irrigation and primary wound closure followed by 10 days of antibiotic therapy has resolved uncomplicated cases [1]. Limited flexor sheath incision and drainage in the emergency department provides a potential safe and effective way to manage patients with early flexor tenosynovitis [19]. No complications were experienced in managing pyogenic flexor tenosynovitis through closed continuous irrigation with lidocaine and immediate mobilization [11].
Anatomy & Pathophysiology¶
Anatomy¶
The flexor tendon sheath contains the flexor tendons and extends from the distal interphalangeal joint proximally to the A1 pulley [25]. The fibroosseous tunnel, or digital flexor sheath, extends distally to the proximal aspect of the distal phalanx [63]. The synovial sheath comprises a visceral and parietal component separated by a potential synovial cavity containing a very thin layer of synovial fluid [64]. This structure allows a considerable amplitude of movement for the flexor tendons [64]. The tenosynovium lining the fibroosseous tunnel supplies nutrition and lubrication to the poorly vascularized flexor tendons [63]. Within the sheath, tendon vascularity is supplied via the vincula system, specifically the vinculum longus and brevis [63]. The A2 and A4 pulleys are the most essential in maintaining the mechanical advantage of the flexor tendons [63].
The thumb flexor tendon sheath is contiguous with the radial bursa [25, 63]. The small finger sheath is contiguous with the ulnar bursa [25, 63]. The radial and ulnar bursae communicate via Parona's space [25]. In some patients, the radial and ulnar bursae communicate, allowing a horseshoe abscess to spread between the thumb and little finger [63]. The radial and ulnar bursae extend up to the carpal tunnel in up to 80% of people [25].
Pathophysiology¶
Pyogenic flexor tenosynovitis is a bacterial infection of the flexor tendon sheath between the visceral layer on the flexor tendon and the parietal layer [25]. It is a closed-space infection of the hand that can result in severe stiffness and other sequela [3]. The condition is most commonly associated with S. aureus after a penetrating trauma [25]. Local inoculation via lacerations, puncture wounds, and bites are more common causes than hematogenous spread [36]. Pyogenic flexor tenosynovitis can also be caused by hematogenous spread [36].
Pus in hand infections is a mixture of bacterial virulence factors, neutrophil-derived degranulation and netosis, dead and dying pathogens, defensive neutrophils, other immune cell types, and dead and dying host structural cells [47]. Infections can spread to the radial and ulnar bursa connections, resulting in a horseshoe abscess [25]. Proximal spread of infection into Parona's space can occur [25].
Pyogenic flexor tenosynovitis can result in tendon necrosis and adhesions leading to marked loss of motion, deformity, and loss of limb, particularly if treatment is delayed [16]. The most common adverse sequelae of acute pyogenic flexor tenosynovitis are loss of digital range of motion and persistent infection [41]. Loss of motion occurs in 10% to 25% of patients with acute pyogenic flexor tenosynovitis [41]. Persistent infection is reported in up to 9% of cases of acute pyogenic flexor tenosynovitis [41]. Persistent infection is more common in patients with purulent exudate discovered intraoperatively, with a 20% incidence [41]. Other reported complications of acute pyogenic flexor tenosynovitis include tendon necrosis with rupture, skin and soft tissue loss necessitating flap coverage, and amputation [41]. Despite aggressive and prompt antibiotic therapy and surgical intervention, otherwise healthy patients can expect some residual digital stiffness following flexor tendon sheath infection [4].
Classification¶
Three-Tier Clinical Classification: A three-tier clinical classification system based on preoperative clinical assessment has been proposed to aid in prognosis and guidance in the treatment of pyogenic flexor tenosynovitis of the upper extremity [7].
Kanavel’s Cardinal Signs: Kanavel’s 4 cardinal symptoms and signs of pyogenic flexor tenosynovitis include exquisite tenderness over the course of the sheath, limited to the sheath [25]. The signs also include a semiflexed position of the finger [25]. Exquisite pain on extending the finger, most marked at the proximal end where definite swelling often may be seen, is a third cardinal sign [25]. The fourth sign is symmetrical swelling of the entire finger [25]. Not all of Kanavel's signs will be present, but when flexor tenosynovitis is suspected, treatment should be instituted immediately to prevent disastrous complications [25].
Other Considerations: The flexor tendon sheath runs from the distal interphalangeal joint proximally to the A1 pulley [25]. The thumb flexor tendon sheath and the radial bursa are contiguous [25]. The small finger sheath and ulna bursa are contiguous [25]. The radial and ulna bursae communicate via Parona's space [25]. The radial and ulna bursae extend up to the carpal tunnel in up to 80% of people [25]. Infections can spread to the radial and ulna bursae connections, with spread to small finger flexor tendon sheaths, resulting in a horseshoe abscess [25]. Proximal spread into Parona's space can occur [25]. In one large series, pyogenic flexor tenosynovitis was reported to represent 9.4% (13/138) of hand infections [16]. CT measurements, specifically the tendon sheath to tendon ratio, can differentiate FTS from finger cellulitis with high sensitivity and specificity [24].
Clinical Presentation¶
Definition and Epidemiology¶
Pyogenic flexor tenosynovitis is an infection of the flexor tendon sheath of the finger [16]. If treatment is delayed, the condition can result in tendon necrosis and adhesions, leading to marked loss of motion, deformity, and loss of limb [16].
Clinical Signs and Symptoms¶
The diagnosis relies on identifying specific clinical signs. Kanavel described three cardinal signs: exquisite tenderness over the course of the sheath limited to the sheath, flexion of the finger, and exquisite pain on extending the finger most marked at the proximal end [16]. Kanavel further noted that the whole of the involved finger is uniformly swollen [16]. These observations are consolidated into four cardinal symptoms and signs: exquisite tenderness over the course of the sheath limited to the sheath, a semiflexed position of the finger, exquisite pain on extending the finger most marked at the proximal end where definite swelling often may be seen, and symmetrical swelling of the entire finger [25]. Not all of Kanavel's signs will be present when flexor tenosynovitis is suspected [25].
Diagnostic Evaluation¶
Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis [28]. Commonly used inflammatory blood markers, including WBC, ESR, and CRP, may be helpful in diagnosing purulent flexor tenosynovitis; if elevated, the likelihood of infection is extremely high [87]. CT measurements, specifically the tendon sheath to tendon ratio, can differentiate flexor tenosynovitis from finger cellulitis with high sensitivity and specificity [24].
Investigations¶
Clinical Examination¶
A careful physical examination is essential to direct care and future testing if indicated [33]. Early recognition and clinical suspicion remain paramount to minimizing potentially devastating consequences from delayed treatment of these infections [16]. Dr Allen B. Kanavel initially described three cardinal signs of pyogenic flexor tenosynovitis in 1912: exquisite tenderness over the course of the sheath limited to the sheath, flexion of the finger, and exquisite pain on extending the finger most marked at the proximal end [16]. Kanavel explained that "the whole of the involved finger is uniformally swollen," although this was not noted in his initial description as a cardinal sign [16].
Imaging¶
MRI: MRI may aid in preoperative diagnosis of vascular malformations in tendon sheaths that present as tenosynovitis [93]. Preoperative imaging was useful in a case of chronic or severe tenosynovitis to assess the condition of flexor tendons [101].
Laboratory and Pathology¶
Laboratory: Three patients presented with classic signs and symptoms of acute bacterial tenosynovitis, but the inflammatory condition was found to be sterile in each instance [17].
Treatment¶
Non-Operative¶
While early recognition and clinical suspicion are paramount to minimizing potentially devastating consequences from delayed treatment [16], and systemic antibiotic use shows benefits [5], surgical decompression remains the treatment of choice for nearly all cases of septic flexor tenosynovitis [2]. There is no standardized treatment algorithm regarding the need for, timing, or type of surgical treatment [36].
Operative¶
Indications: Management of pyogenic flexor tenosynovitis includes prompt administration of empirical intravenous antibiotics and often surgical treatment [36]. When flexor tenosynovitis is suspected, treatment should be instituted immediately to prevent disastrous complications including tendon adhesions or necrosis [25]. Expediency in treatment potentially improves final motion and function [2].
Surgical Approach / Technique: Early diagnosis followed by drainage through small incisions and continuous postoperative irrigation appears to lead to the best functional outcome [18]. Limited flexor sheath incision and drainage in the emergency department provides a potential safe and effective way to manage patients with early flexor tenosynovitis [19]. For mycobacterial flexor tenosynovitis, immediate operative debridement and flexor sheath irrigation, followed by a full course of antimycobacterial antibiotic therapy managed by an infectious disease specialist, optimize chances of acceptable functional outcome and infection eradication [14]. Successful management of Mycobacterium asiaticum flexor tenosynovitis included radical flexor tenosynovectomy and therapy with oral minocycline and clarithromycin [32]. Treatment of Candida albicans tenosynovitis was successful after radical synovectomy of both the flexor and extensor aspects of the hand after failure to respond to combined amphotericin B and 5-fluorouracil therapy [53]. Standard two-stage flexor tendon reconstruction is a reasonable option once tuberculous infection has been adequately treated and is not associated with recurrence of that infection [23]. The disease will respond to a combined treatment of tendon sheath drainage, irrigation, and antibiotics, whereas antibiotics alone may be insufficient for acute gonococcal flexor tenosynovitis [98].
Postoperative Care: Continuous postoperative catheter irrigation is not necessary for the treatment of suppurative flexor tenosynovitis, as there were no statistically significant differences in outcomes between patients receiving intraoperative irrigation only and those receiving both intraoperative and continuous postoperative irrigation [72].
Outcomes: The advent of antibiotics and appropriate surgical treatment has decreased the risk of serious sequelae secondary to pyogenic flexor tenosynovitis [16]. Complication rates for pyogenic flexor tenosynovitis can be high, leading to impaired function and even amputation of the affected digit, despite prompt treatment [36]. Flexor tenosynovitis along with proper antibiotic treatment resulted in complete resolution in a patient with chronic tenosynovitis caused by Actinobacillus actinomycetemcomitans [21].
Complications¶
Stiffness / Arthrofibrosis: Pyogenic flexor tenosynovitis frequently results in severe stiffness and other sequelae [3]. Even in otherwise healthy patients, residual digital stiffness is expected following flexor tendon sheath infection, despite aggressive and prompt antibiotic therapy and surgical intervention [4]. This stiffness arises from scarring and inflammation causing oedema of the soft tissues of the finger [13].
Tissue Destruction: The consequences of pyogenic flexor tenosynovitis can include destruction of the tendon sheath [13]. In severe cases, despite timely and thorough treatment, infection can lead to impaired function or even amputation of the affected digit [37]. Pyogenic flexor tenosynovitis can also lead to digital ischaemic necrosis and amputation [13, 6].
Compartment Syndrome: Pyogenic flexor tenosynovitis can result in compartment syndrome [13].
Other Considerations: A rare complication of acute pyogenic flexor tenosynovitis is the isolation of Nocardia nova from the affected digit approximately 6 weeks after surgical treatment [46].
Recovery¶
Other Considerations: The consequences of pyogenic flexor tenosynovitis can include destruction of the tendon sheath, scarring and inflammation causing oedema of the soft tissues of the finger with resultant finger stiffness or, occasionally, compartment syndrome [13]. Expediency in surgical decompression potentially improves final motion and function [2].
Key Evidence¶
- [L4] A single open debridement with irrigation and primary wound closure followed by 10 days of antibiotic therapy resolved uncomplicated pyogenic flexor tenosynovitis. [1] (10.1007/s00402-016-2587-5)
- [L5] Surgical decompression is the treatment of choice for nearly all cases of septic flexor tenosynovitis, with expediency potentially improving final motion and function. [2] (10.1016/j.jhsa.2010.11.033)
- [L5] Pyogenic flexor tenosynovitis (PFT) is an uncommon closed-space infection of the hand that can result in severe stiffness and other sequela. [3] (10.2106/jbjs.rvw.26.00015)
- [L5] Despite aggressive and prompt antibiotic therapy and surgical intervention, even otherwise healthy patients can expect some residual digital stiffness following flexor tendon sheath infection. [4] (10.5435/jaaos-20-06-373)
- [L3] The studies showed benefits of early treatment of pyogenic flexor tenosynovitis and of systemic antibiotic use. [5] (10.1177/1753193415570248)
- [L5] Pyogenic flexor tenosynovitis is a relatively common but often misdiagnosed hand infection. [6] (10.1136/bcr-2012-006778)
- [L2] The authors propose a three-tier clinical classification system based on preoperative clinical assessment to aid in prognosis and guidance in the treatment of pyogenic flexor tenosynovitis of the upper extremity. [7] (10.2106/jbjs.f.01356)
- [L2] Ultrasound is useful as a diagnostic tool for managing early pyogenic flexor tenosynovitis thanks to its excellent negative predictive value and specificity. [8] (10.1016/j.hansur.2017.12.004)
- [L5] Pyogenic flexor tenosynovitis is a closed-space infection of the finger or thumb flexor tendon sheath or the radial and ulnar bursae. [9] (10.1016/s0749-0712(21)00418-2)
- [L4] Pyogenic flexor tenosynovitis may result in uniform finger swelling, but this does not appear to distinguish PFT from other finger infections. [10] (10.1016/j.jhsa.2019.01.013)
- [L4] No complications were experienced in managing pyogenic flexor tenosynovitis through this approach. [11] (10.1097/bth.0000000000000164)
- [L5] The consequences of pyogenic flexor tenosynovitis can be destruction of the tendon sheath, scarring and inflammation causing oedema of the soft tissues of the finger with resultant finger stiffness or, occasionally, compartment syndrome. [13] (10.1016/j.jhsb.2006.02.019)
- [Case_report] Immediate operative debridement and flexor sheath irrigation, followed by a full course of antimycobacterial antibiotic therapy managed by an infectious disease specialist, optimize chances of acceptable functional outcome and infection eradication. [14] (10.1016/j.jhsa.2012.11.011)
- [Paper] The presence of pus within the flexor sheath is the only significant predictive factor for repeated flexor tendon washout. [15] (10.1055/s-0040-1715556)
- [L5] [16] (10.1007/s11999-015-4367-x)
- [L4] Three patients presented with classic signs and symptoms of acute bacterial tenosynovitis, but the inflammatory condition was found to be sterile in each instance. [17] (10.1016/s0363-5023(86)80122-8)
- [L4] Early diagnosis of purulent flexor tenosynovitis followed by drainage through small incisions and continuous postoperative irrigation appear to lead to the best functional outcome. [18] (10.1177/1753193408087071)
- [L4] Limited flexor sheath I&D in the ED provides a potential safe and effective way to manage patients with early flexor tenosynovitis. [19] (10.1177/1558944721999729)
- [L5] Flexor tenosynovitis along with proper antibiotic treatment resulted in complete resolution in this patient. [21] (10.1016/s0363-5023(87)80294-0)
- [L4] Standard two-stage flexor tendon reconstruction is a reasonable option once the tuberculous infection has been adequately treated and is not associated with recurrence of that infection. [23] (10.1177/1753193409360604)
- [L3] The study demonstrates that CT measurements, specifically the tendon sheath to tendon ratio, can differentiate FTS from finger cellulitis with high sensitivity and specificity. [24] (10.1177/15589447221092058)
- [L5] [25] (10.1016/j.jhsa.2011.05.035)
- [L5] Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis. [28] (10.1016/j.hcl.2020.03.002)
- [L5] Successful management included radical flexor tenosynovectomy and therapy with oral minocycline and clarithromycin. [32] (10.1016/s0363-5023(98)80066-x)
- [L5] [36] (10.1016/j.jhsa.2019.04.011)
- [Paper] [37] (10.1055/s-0039-1700370)
- [L4] [41] (10.1097/bth.0b013e3181bef5a3)
- [L4] This case is unique in that the patient experienced a rare complication of acute pyogenic flexor tenosynovitis with a previously unreported organism isolate of Nocardia nova cultured from the affected digit approximately 6 weeks after surgical treatment. [46] (10.1016/j.jhsa.2017.11.016)
- [L5] [47] (10.1177/17531934231174819)
- [L5] Treatment was successful after radical synovectomy of both the flexor and extensor aspects of the hand after he failed to respond to combined amphotericin B and 5-fluorouracil therapy. [53] (10.1016/s0363-5023(85)80217-3)
- [L3] [72] (10.1054/jhsb.2000.0400)
- [L3] Commonly used inflammatory blood markers (WBC, ESR, and CRP) may be helpful in diagnosing purulent flexor tenosynovitis; if elevated, the likelihood of infection is extremely high. [87] (10.1016/j.jhsa.2013.08.094)
- [L4] Vascular malformations in tendon sheaths can present as tenosynovitis, creating a diagnostic challenge; early diagnosis and treatment are necessary to prevent complications, and MRI may aid in preoperative diagnosis. [93] (10.1007/s11552-011-9384-y)
- [L5] The disease will respond to a combined treatment of tendon sheath drainage, irrigation, and antibiotics, where as antibiotics alone may be insufficient. [98] (10.1016/s0363-5023(81)80106-2)
- [L4] Preoperative imaging was useful in a case of chronic or severe tenosynovitis to assess the condition of flexor tendons, and wide-awake surgery was the appropriate procedure for the treatment of this case. [101] (10.1055/s-0038-1645951)
See Also¶
References¶
[1] Treatment of digital pyogenic flexor tenosynovitis: single open debridement, irrigation, and primary wound closure followed by antibiotic therapy. Archives of Orthopaedic and Trauma Surgery. 2016. DOI: 10.1007/s00402-016-2587-5
[2] Septic Flexor Tenosynovitis. The Journal of Hand Surgery. 2011. DOI: 10.1016/j.jhsa.2010.11.033
[3] Management of Pyogenic Flexor Tenosynovitis. JBJS Reviews. 2026. DOI: 10.2106/jbjs.rvw.26.00015
[4] Flexor Tendon Sheath Infections of the Hand. Journal of the American Academy of Orthopaedic Surgeons. 2012. DOI: 10.5435/jaaos-20-06-373
[5] A systematic review of the management of acute pyogenic flexor tenosynovitis. Journal of Hand Surgery (European Volume). 2015. DOI: 10.1177/1753193415570248
[6] Pyogenic flexor tenosynovitis leading to an amputation. BMJ Case Reports. 2012. DOI: 10.1136/bcr-2012-006778
[7] Factors Affecting the Prognosis of Pyogenic Flexor Tenosynovitis. The Journal of Bone & Joint Surgery. 2007. DOI: 10.2106/jbjs.f.01356
[8] Usefulness of ultrasound for the diagnosis of pyogenic flexor tenosynovitis: A prospective single-center study of 57 cases. Hand Surgery and Rehabilitation. 2018. DOI: 10.1016/j.hansur.2017.12.004
[9] PYOGENIC FLEXOR TENOSYNOVITIS. Hand Clinics. 1998. DOI: 10.1016/s0749-0712(21)00418-2
[10] Radiographic Soft Tissue Thickness Differentiating Pyogenic Flexor Tenosynovitis From Other Finger Infections. The Journal of Hand Surgery. 2019. DOI: 10.1016/j.jhsa.2019.01.013
[11] Closed Continuous Irrigation With Lidocaine and Immediate Mobilization for Treatment of Pyogenic Tenosynovitis. Techniques in Hand & Upper Extremity Surgery. 2017. DOI: 10.1097/bth.0000000000000164
[13] MRSA Pyogenic Flexor Tenosynovitis Leading to Digital Ischaemic Necrosis and Amputation. Journal of Hand Surgery. 2006. DOI: 10.1016/j.jhsb.2006.02.019
[14] Acute Mycobacterial Flexor Tenosynovitis Following Accidental Bacillus Calmette-Guérin Inoculation in a Health Care Worker: Case Report. The Journal of Hand Surgery. 2013. DOI: 10.1016/j.jhsa.2012.11.011
[15] Prognostic Factors for Repeated Flexor Tenosynovitis Washout: A Retrospective Study. Journal of Hand and Microsurgery. 2022. DOI: 10.1055/s-0040-1715556
[16] In Brief: Kanavel's Signs and Pyogenic Flexor Tenosynovitis. Clinical Orthopaedics & Related Research. 2016. DOI: 10.1007/s11999-015-4367-x
[17] Sterile flexor tenosynovitis of the hand: A report of three cases. The Journal of Hand Surgery. 1986. DOI: 10.1016/s0363-5023(86)80122-8
[18] Purulent Flexor Tenosynovitis: Factors Influencing the Functional Outcome. Journal of Hand Surgery (European Volume). 2008. DOI: 10.1177/1753193408087071
[19] Limited Flexor Sheath Incision and Drainage in the Emergency Department in the Management of Early Pyogenic Flexor Tenosynovitis. HAND. 2021. DOI: 10.1177/1558944721999729
[21] Chronic tenosynovitis caused by Actinobacillus actinomycetemcomitans. The Journal of Hand Surgery. 1987. DOI: 10.1016/s0363-5023(87)80294-0
[23] Staged flexor tendon reconstruction in a patient with caseous tuberculous tenosynovitis. Journal of Hand Surgery (European Volume). 2010. DOI: 10.1177/1753193409360604
[24] Contrast Enhanced Computed Tomography in the Diagnosis of Acute Pyogenic Flexor Tenosynovitis. HAND. 2022. DOI: 10.1177/15589447221092058
[25] Hand Infections. The Journal of Hand Surgery. 2011. DOI: 10.1016/j.jhsa.2011.05.035
[28] Imaging and Laboratory Workup for Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.002
[32] Flexor tenosynovitis due to Mycobacterium asiaticum. The Journal of Hand Surgery. 1998. DOI: 10.1016/s0363-5023(98)80066-x
[33] Orthopaedic Knowledge Update 13 Ebook Without Multimedia. Anatomy, Evaluation, Clinical Examination, and Imaging > Evaluation and Clinical Examination: Current Concepts.
[36] Pyogenic Flexor Tenosynovitis: Evaluation and Treatment Strategies. The Journal of Hand Surgery. 2019. DOI: 10.1016/j.jhsa.2019.04.011
[37] Pyogenic Flexor Tenosynovitis: Evaluation and Treatment Strategies. Journal of Hand and Microsurgery. 2019. DOI: 10.1055/s-0039-1700370
[41] Use of Continuous Marcaine Irrigation in the Management of Suppurative Flexor Tenosynovitis. Techniques in Hand & Upper Extremity Surgery. 2009. DOI: 10.1097/bth.0b013e3181bef5a3
[46] A Rare Cause of Pyogenic Flexor Tenosynovitis: Nocardia nova. The Journal of Hand Surgery. 2018. DOI: 10.1016/j.jhsa.2017.11.016
[47] Hand infection: a management approach based on a new understanding of combined bacterial and neutrophil mediated tissue damage. Journal of Hand Surgery (European Volume). 2023. DOI: 10.1177/17531934231174819
[53] Candida albicans tenosynovitis of the hand. The Journal of Hand Surgery. 1985. DOI: 10.1016/s0363-5023(85)80217-3
[63] A Lange Medical Book Current Diagnosis Treatment In Orthopedics Fifth Edition. 9Hand Surgery > FLEXOR TENDON INJURY.
[64] Exam Of The Hand Wrist 2Ed. 1.3 MOVEMENTS OF THE HAND AND WRIST > Gliding mechanisms.
[72] Continuous Postoperative Catheter Irrigation is not Necessary for the Treatment of Suppurative Flexor Tenosynovitis. Journal of Hand Surgery. 2000. DOI: 10.1054/jhsb.2000.0400
[87] The Diagnostic Accuracy of Inflammatory Blood Markers for Purulent Flexor Tenosynovitis. The Journal of Hand Surgery. 2013. DOI: 10.1016/j.jhsa.2013.08.094
[93] Vascular Malformation of the Flexor Tendon Presenting as Tenosynovitis. HAND. 2011. DOI: 10.1007/s11552-011-9384-y
[98] Acute gonococcal flexor tenosynovitis-Case report and literature review. The Journal of Hand Surgery. 1981. DOI: 10.1016/s0363-5023(81)80106-2
[101] Flexor Tendon Entrapment Caused by Intratendinous Tumor-Like Chronic Proliferative Tenosynovitis. Journal of Hand and Microsurgery. 2019. DOI: 10.1055/s-0038-1645951