Clinicians › Hand
Infected Flexor Sheath (Pyogenic Flexor Tenosynovitis)

For patients: a plain-language version of this topic is available. See the patient guide.
Overview¶
Pyogenic flexor tenosynovitis is a closed-space infection of the finger or thumb flexor tendon sheath or the radial and ulnar bursae [3]. While uniform finger swelling may occur, this finding does not appear to distinguish pyogenic flexor tenosynovitis from other finger infections [4]. Ultrasound serves as a useful diagnostic tool for managing early cases, owing to its excellent negative predictive value and specificity [10]. A three-tier clinical classification system based on preoperative clinical assessment has been proposed to aid in prognosis and guide treatment for upper extremity cases [2].
Surgical decompression is the treatment of choice for nearly all cases of septic flexor tenosynovitis [6]. Expediency in surgical decompression potentially improves final motion and function [6]. Studies have demonstrated the benefits of both early treatment and systemic antibiotic use for pyogenic flexor tenosynovitis [5]. In uncomplicated cases, a single open debridement with irrigation and primary wound closure followed by 10 days of antibiotic therapy has resolved the infection [1].
Despite aggressive and prompt antibiotic therapy and surgical intervention, even otherwise healthy patients can expect some residual digital stiffness following flexor tendon sheath infection [8].
Anatomy & Pathophysiology¶
Anatomy¶
The flexor tendon sheath encloses the flexor tendons, extending from the distal interphalangeal joint proximally to the A1 pulley [18]. Anatomical continuity exists between the thumb flexor tendon sheath and the radial bursa, as well as between the small finger sheath and the ulnar bursa [18]. The radial and ulnar bursae communicate via Parona's space and extend into the carpal tunnel in up to 80% of individuals [18]. Infection can spread through these connections to the small finger flexor tendon sheaths, resulting in a horseshoe abscess, or proximally into Parona's space from the flexor tendon sheath [18].
Pathophysiology¶
Pyogenic flexor tenosynovitis is a bacterial infection located between the visceral layer on the flexor tendon and the parietal layer of the sheath [18]. Staphylococcus aureus following penetrating trauma is the most common etiology, though hematogenous spread is also a recognized cause [18, 21]. Local inoculation via lacerations, puncture wounds, and bites occurs more frequently than hematogenous spread [21]. This condition accounts for 2.5% to 9.4% of all hand infections, with one large series reporting a prevalence of 9.4% (13/138) [21, 11].
Clinical presentation may include uniform finger swelling, a finding that does not distinguish pyogenic flexor tenosynovitis from other finger infections [4]. Kanavel's four cardinal signs include: * Exquisite tenderness: Localized over the course of the sheath [18]. * Semiflexed position: The finger rests in a semiflexed posture [18]. * Pain on extension: Exquisite pain occurs upon extending the finger, most marked at the proximal end where definite swelling may be observed [18]. * Symmetrical swelling: The entire finger exhibits symmetrical swelling [18].
Not all of Kanavel's signs are necessarily present in every case [18]. If treatment is delayed, the infection can lead to tendon necrosis and adhesions, causing marked loss of motion, deformity, and potential loss of the limb [11].
Classification¶
Kanavel's Signs: The presence of all four classic signs is not required for diagnosis; however, when flexor tenosynovitis is suspected, immediate treatment must be instituted to prevent disastrous complications [18]. In a retrospective study of 40 patients, the number of Kanavel signs and the duration of symptoms were significantly greater in the surgical management group compared with the early antibiotics only group [40]. No statistical significance was found regarding age, smoking status, or specific individual Kanavel signs between these two groups [40]. Patients presenting with a shorter duration of symptoms and fewer Kanavel signs were treated successfully with antibiotics alone [40]. Conversely, operatively confirmed flexor tenosynovitis presented more acutely, characterized by fewer days of symptoms and a higher number of Kanavel signs [40].
Other Considerations: Patients with subacute presentations may represent inflammatory conditions rather than infection [40]. Computed tomography measurements, specifically the tendon sheath to tendon ratio, can differentiate flexor tenosynovitis from finger cellulitis with high sensitivity and specificity [15]. Pyogenic flexor tenosynovitis may result in uniform finger swelling, but this finding does not appear to distinguish pyogenic flexor tenosynovitis from other finger infections [4].
Clinical Presentation¶
Pyogenic flexor tenosynovitis is a relatively common but often misdiagnosed hand infection [9]. The condition is most commonly associated with S aureus following penetrating trauma [18]. While not all of Kanavel's signs will be present, the clinical suspicion of flexor tenosynovitis mandates immediate treatment to prevent disastrous complications, including tendon adhesions or even necrosis [18].
Diagnostic Evaluation¶
Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis [19]. CT measurements, specifically the tendon sheath to tendon ratio, can differentiate FTS from finger cellulitis with high sensitivity and specificity [15]. The presence of pus within the flexor sheath is the only significant predictive factor for repeated flexor tendon washout [13].
Prognosis and Outcomes¶
A three-tier clinical classification system based on preoperative clinical assessment is proposed to aid in prognosis and guidance in the treatment of pyogenic flexor tenosynovitis of the upper extremity [2].
Investigations¶
Clinical Examination¶
Kanavel described three cardinal signs of pyogenic flexor tenosynovitis: exquisite tenderness over the course of the sheath limited to the sheath, flexion of the finger, and exquisite pain on extending the finger most marked at the proximal end [11]. Kanavel also noted that the whole of the involved finger is uniformly swollen, although this was not initially described as a cardinal sign [11]. A three-tier clinical classification system based on preoperative clinical assessment has been proposed to aid in prognosis and treatment guidance for pyogenic flexor tenosynovitis [2]. A careful physical examination is essential to direct care and future testing if indicated, as diagnostic tests can be expensive, time consuming, and often nonspecific [20].
Imaging¶
Ultrasound: Ultrasound is useful as a diagnostic tool for managing early pyogenic flexor tenosynovitis due to its excellent negative predictive value and specificity [10]. Point-of-care ultrasound has been utilized in the emergency department for the diagnosis of pyogenic flexor tenosynovitis [22].
CT: Contrast-enhanced computed tomography measurements, specifically the tendon sheath to tendon ratio, can differentiate flexor tenosynovitis from finger cellulitis with high sensitivity and specificity [15].
MRI: MRI may aid in the preoperative diagnosis of vascular malformations in tendon sheaths that present as tenosynovitis [44].
Other Considerations: Pyogenic flexor tenosynovitis may result in uniform finger swelling, but this finding does not appear to distinguish pyogenic flexor tenosynovitis from other finger infections [4]. Preoperative imaging was useful in assessing the condition of flexor tendons in cases of chronic or severe tenosynovitis [46].
Treatment¶
Non-Operative¶
No patients with suspicion for pyogenic flexor tenosynovitis based on specific criteria were managed with antibiotics alone [16].
Operative¶
Indications: Expediency in surgical treatment potentially improves final motion and function [6]. Early diagnosis of purulent flexor tenosynovitis followed by drainage through small incisions and continuous postoperative irrigation appear to lead to the best functional outcome [12]. Patients with frank purulence on clinical examination are taken immediately to the operating room for irrigation and debridement and flexor sheath washout [16]. Frank purulence is defined as draining purulence from a wound or the presence of a diffuse subcutaneous and/or palpable abscess [16]. Patients with pyogenic flexor tenosynovitis but without frank findings of purulence on examination may undergo a limited bedside flexor sheath irrigation and debridement in the emergency department [16].
Surgical Approach / Technique: A designation of purulence after irrigation and debridement is defined by the clinical provider as an overt thick, white, odorous fluid expressed from the hand [16]. Fluid types including dark, cloudy, bloody, or clear fluid are deemed as nonpurulent and as a possible manifestation of early flexor tenosynovitis [16]. If purulence is encountered during limited bedside irrigation and debridement, patients are taken to the operating room [16]. For limited bedside procedures, an oblique Bruner incision is made over the area(s) of concern [16], and a longitudinal incision is made along the most volar aspect of the flexor sheath [16]. Abnormal fluid expressed either subcutaneously or from within the flexor sheath is cultured during limited bedside irrigation and debridement [16]. The wound is irrigated with sterile saline fluid and a bulky soft dressing is applied during limited bedside irrigation and debridement [16].
Adjuncts: Management of pyogenic flexor tenosynovitis includes prompt administration of empirical intravenous antibiotics [21]. Systemic antibiotic use shows benefits in the management of acute pyogenic flexor tenosynovitis [5].
Prognosis and Outcomes: Early treatment of pyogenic flexor tenosynovitis shows benefits [5]. Complication rates can be high, leading to impaired function and even amputation of the affected digit, despite prompt treatment and regardless of the protocol used [21].
Complications¶
Stiffness / Arthrofibrosis: Even otherwise healthy patients can expect some residual digital stiffness following flexor tendon sheath infection despite aggressive and prompt antibiotic therapy and surgical intervention [8]. This outcome persists even when management includes early diagnosis, drainage through small incisions, and continuous postoperative irrigation, which are associated with the best functional outcomes [12].
Infection (PJI): Severe infection can lead to impaired function or even amputation of the affected digit despite timely and thorough treatment [24].
Other Considerations: A three-tier clinical classification system based on preoperative clinical assessment has been proposed to aid in prognosis and guidance in the treatment of pyogenic flexor tenosynovitis [2]. Surgical decompression is the treatment of choice for nearly all cases of septic flexor tenosynovitis, with expediency potentially improving final motion and function [6]. Studies have shown benefits of early treatment of pyogenic flexor tenosynovitis and of systemic antibiotic use [5].
Key Evidence¶
- [L4] A single open debridement with irrigation and primary wound closure followed by 10 days of antibiotic therapy resolved uncomplicated pyogenic flexor tenosynovitis. [1] (10.1007/s00402-016-2587-5)
- [L2] The authors propose a three-tier clinical classification system based on preoperative clinical assessment to aid in prognosis and guidance in the treatment of pyogenic flexor tenosynovitis of the upper extremity. [2] (10.2106/jbjs.f.01356)
- [L5] Pyogenic flexor tenosynovitis is a closed-space infection of the finger or thumb flexor tendon sheath or the radial and ulnar bursae. [3] (10.1016/s0749-0712(21)00418-2)
- [L4] Pyogenic flexor tenosynovitis may result in uniform finger swelling, but this does not appear to distinguish PFT from other finger infections. [4] (10.1016/j.jhsa.2019.01.013)
- [L3] The studies showed benefits of early treatment of pyogenic flexor tenosynovitis and of systemic antibiotic use. [5] (10.1177/1753193415570248)
- [L5] Surgical decompression is the treatment of choice for nearly all cases of septic flexor tenosynovitis, with expediency potentially improving final motion and function. [6] (10.1016/j.jhsa.2010.11.033)
- [L5] Despite aggressive and prompt antibiotic therapy and surgical intervention, even otherwise healthy patients can expect some residual digital stiffness following flexor tendon sheath infection. [8] (10.5435/jaaos-20-06-373)
- [L5] Pyogenic flexor tenosynovitis is a relatively common but often misdiagnosed hand infection. [9] (10.1136/bcr-2012-006778)
- [L2] Ultrasound is useful as a diagnostic tool for managing early pyogenic flexor tenosynovitis thanks to its excellent negative predictive value and specificity. [10] (10.1016/j.hansur.2017.12.004)
- [L5] [11] (10.1007/s11999-015-4367-x)
- [L4] Early diagnosis of purulent flexor tenosynovitis followed by drainage through small incisions and continuous postoperative irrigation appear to lead to the best functional outcome. [12] (10.1177/1753193408087071)
- [Paper] The presence of pus within the flexor sheath is the only significant predictive factor for repeated flexor tendon washout. [13] (10.1055/s-0040-1715556)
- [L3] The study demonstrates that CT measurements, specifically the tendon sheath to tendon ratio, can differentiate FTS from finger cellulitis with high sensitivity and specificity. [15] (10.1177/15589447221092058)
- [L4] [16] (10.1177/1558944721999729)
- [L5] [18] (10.1016/j.jhsa.2011.05.035)
- [L5] Hand and upper-extremity infections are usually a clinical diagnosis, but imaging and laboratory evaluation aid in diagnosis. [19] (10.1016/j.hcl.2020.03.002)
- [L5] [21] (10.1016/j.jhsa.2019.04.011)
- [L4] [22] (10.5811/cpcem.2018.3.37415)
- [Paper] Despite timely and thorough treatment, severe infection can nevertheless lead to impaired function or even amputation of the affected digit. [24] (10.1055/s-0039-1700370)
- [L4] [40] (10.1177/15589447211043187)
- [L4] Vascular malformations in tendon sheaths can present as tenosynovitis, creating a diagnostic challenge; early diagnosis and treatment are necessary to prevent complications, and MRI may aid in preoperative diagnosis. [44] (10.1007/s11552-011-9384-y)
- [L4] Preoperative imaging was useful in a case of chronic or severe tenosynovitis to assess the condition of flexor tendons, and wide-awake surgery was the appropriate procedure for the treatment of this case. [46] (10.1055/s-0038-1645951)
See Also¶
References¶
[1] Treatment of digital pyogenic flexor tenosynovitis: single open debridement, irrigation, and primary wound closure followed by antibiotic therapy. Archives of Orthopaedic and Trauma Surgery. 2016. DOI: 10.1007/s00402-016-2587-5
[2] Factors Affecting the Prognosis of Pyogenic Flexor Tenosynovitis. The Journal of Bone & Joint Surgery. 2007. DOI: 10.2106/jbjs.f.01356
[3] PYOGENIC FLEXOR TENOSYNOVITIS. Hand Clinics. 1998. DOI: 10.1016/s0749-0712(21)00418-2
[4] Radiographic Soft Tissue Thickness Differentiating Pyogenic Flexor Tenosynovitis From Other Finger Infections. The Journal of Hand Surgery. 2019. DOI: 10.1016/j.jhsa.2019.01.013
[5] A systematic review of the management of acute pyogenic flexor tenosynovitis. Journal of Hand Surgery (European Volume). 2015. DOI: 10.1177/1753193415570248
[6] Septic Flexor Tenosynovitis. The Journal of Hand Surgery. 2011. DOI: 10.1016/j.jhsa.2010.11.033
[8] Flexor Tendon Sheath Infections of the Hand. Journal of the American Academy of Orthopaedic Surgeons. 2012. DOI: 10.5435/jaaos-20-06-373
[9] Pyogenic flexor tenosynovitis leading to an amputation. BMJ Case Reports. 2012. DOI: 10.1136/bcr-2012-006778
[10] Usefulness of ultrasound for the diagnosis of pyogenic flexor tenosynovitis: A prospective single-center study of 57 cases. Hand Surgery and Rehabilitation. 2018. DOI: 10.1016/j.hansur.2017.12.004
[11] In Brief: Kanavel's Signs and Pyogenic Flexor Tenosynovitis. Clinical Orthopaedics & Related Research. 2016. DOI: 10.1007/s11999-015-4367-x
[12] Purulent Flexor Tenosynovitis: Factors Influencing the Functional Outcome. Journal of Hand Surgery (European Volume). 2008. DOI: 10.1177/1753193408087071
[13] Prognostic Factors for Repeated Flexor Tenosynovitis Washout: A Retrospective Study. Journal of Hand and Microsurgery. 2022. DOI: 10.1055/s-0040-1715556
[15] Contrast Enhanced Computed Tomography in the Diagnosis of Acute Pyogenic Flexor Tenosynovitis. HAND. 2022. DOI: 10.1177/15589447221092058
[16] Limited Flexor Sheath Incision and Drainage in the Emergency Department in the Management of Early Pyogenic Flexor Tenosynovitis. HAND. 2021. DOI: 10.1177/1558944721999729
[18] Hand Infections. The Journal of Hand Surgery. 2011. DOI: 10.1016/j.jhsa.2011.05.035
[19] Imaging and Laboratory Workup for Hand Infections. Hand Clinics. 2020. DOI: 10.1016/j.hcl.2020.03.002
[20] Orthopaedic Knowledge Update 13 Ebook Without Multimedia. Anatomy, Evaluation, Clinical Examination, and Imaging > Evaluation and Clinical Examination: Current Concepts.
[21] Pyogenic Flexor Tenosynovitis: Evaluation and Treatment Strategies. The Journal of Hand Surgery. 2019. DOI: 10.1016/j.jhsa.2019.04.011
[22] Pyogenic Flexor Tenosynovitis by Point-of-care Ultrasound in the Emergency Department. Clinical Practice and Cases in Emergency Medicine. 2018. DOI: 10.5811/cpcem.2018.3.37415
[24] Pyogenic Flexor Tenosynovitis: Evaluation and Treatment Strategies. Journal of Hand and Microsurgery. 2019. DOI: 10.1055/s-0039-1700370
[40] Antibiotics Versus Surgery in Treatment of Early Flexor Tenosynovitis. HAND. 2022. DOI: 10.1177/15589447211043187
[44] Vascular Malformation of the Flexor Tendon Presenting as Tenosynovitis. HAND. 2011. DOI: 10.1007/s11552-011-9384-y
[46] Flexor Tendon Entrapment Caused by Intratendinous Tumor-Like Chronic Proliferative Tenosynovitis. Journal of Hand and Microsurgery. 2019. DOI: 10.1055/s-0038-1645951