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Glomus Tumour

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Overview¶
Glomus tumors are rare vascular neoplasms, encountered in 0.26% of patients (8 of 3014) referring for hand surgery over a 10-year period [15]. They represent one of the most painful clinical conditions confirmed by comprehensive clinical assessment [2]. Although symptoms and signs are relatively sensitive and specific when used in combination [4], the diagnosis is primarily clinical because imaging techniques do not provide a specific image of the tumor [12]. Consequently, a high index of suspicion is of primary importance when dealing with these lesions [3, 7]. These findings highlight the continued importance of clinical suspicion in glomus tumor diagnosis [1].
Clinicians must be aware that glomus tumors can present with severe morbidity despite subtle clinical signs [11]. Multiple digital glomus tumors are a definite entity, occurring in seven of 28 patients in a specific series [16]. Patients should be counseled before surgery regarding the possibility of multiple glomus tumors [7]. Clinicians should search for synchronous glomus tumors during excision to avoid recurrence or persistence of symptoms due to undiscovered multiple lesions [20]. Familiarity with extradigital glomus tumors will enable hand surgeons to provide patients with long-term relief from this unusual problem [8].
Glomus tumours are often misdiagnosed and are intervened with different treatment options before being surgically intervened [14]. A retrospective study of 11 patients with glomus tumors of the hand showed a mean age of 36.27 years and a mean follow-up of 34.40 months [46]. Although glomus tumors in children are extremely rare, most are benign and can be completely cured through surgical excision [70]. The rare nature of malignant glomus tumors mandates case presentation and longitudinal analysis to help guide surgical management and optimize outcomes [9]. Although some reports suggest that glomus tumours of uncertain malignant potential do not metastasise, a case demonstrates an unfavourable and aggressive clinical course [17]. The treatment of choice for glomangiosarcomas is wide local excision [42].
Anatomy & Pathophysiology¶
Glomus Body Anatomy and Physiology¶
The glomus body is a specialized arteriovenous anastomosis located in the dermis, specifically within the stratum reticularis [43, 45]. It functions in thermoregulation by controlling skin blood flow [43, 64]. Structurally, the glomus body consists of an afferent arteriole derived from small dermal arterioles [64]. Round, epithelial-appearing glomus cells, which are specialized cells closely related to pericytes and myocytes, surround the anastomosis alongside smooth muscle fibers and neuroreticular elements [45]. The entire glomic complex is encompassed by lamellated collagenous tissue containing small nerves and blood vessels, with unmyelinated nerve fibers typically found within and surrounding the body [45].
Tumor Histology and Origin¶
Glomus tumors are benign, highly organized, and well-differentiated neoplasms composed of modified smooth muscle cells that resemble normal glomus body cells [43]. They are considered hamartomatous proliferations originating from normal glomus cell populations within the glomus neuro-myo-arterial system [64, 21]. These rare tumors represent approximately 5% of soft tissue tumors of the hand, though other sources cite a range of 1–2% [21, 64]. Glomus tumors are usually small (less than 1 cm) and solitary, although lesions between 3 cm and 5 cm in deep locations and multiple glomus tumor lesions have been described [43]. Glomangiomas are also benign and develop from the glomus body [44].
Anatomical Distribution¶
Glomus tumors most commonly occur in the fingers, with the distal phalanx, particularly the subungual region, being the most frequent site [43, 31]. Hand glomus tumors show a predominance on the ring finger [71]. While extradigital sites are not uncommon and account for 11–65% of all cases, they are almost invariably subcutaneous [43, 64]. The forearm is the most common extradigital location, whereas glomus tumors about the wrist area are rare [39, 40]. These tumors can arise at sites where normal glomus bodies may be sparse or absent, including muscle, bone, blood vessels, and nerve [43]. Extradigital glomus tumors have been reported to be more common in men, although most subungual lesions occur in women [64].
Pathophysiology of Pain¶
The characteristic clinical presentation includes exquisite superficial tenderness and paroxysms of pain often associated with temperature change or cold [43]. The classic triad consists of paroxysmal pain, localized tenderness, and cold intolerance [64]. Glomus tumors present as small red-blue nodules initially accompanied by a paroxysm of pain radiating away from the lesion, with extreme point tenderness and cold insensitivity being characteristic features [45]. The precise mechanism of pain production is not yet established [43]. However, glomus bodies lie in a rich neural bed under neurologic control, and glomus cells are adjacent to this neural bed, which may explain the severe pain and hypersensitivity [43, 64]. A pain-associated vasoactive peptide, substance P, has been observed within nerve fibers in glomus tumors [43]. Additionally, mast cells of the glomus tumor may play an important role in mediating pain [64]. Occasionally, a glomus tumor can cause pain by directly compressing forearm nerves [64].
Etiology and Risk Factors¶
The etiology of glomus tumors is not clear [64]. An autosomal dominant pattern of inheritance has been reported [64]. A history of injury is cited as a factor in development, and although trauma as a causative factor has not been confirmed, several retrospective studies mention preceding trauma or injury to the area where the tumor developed [64, 35]. In a study of 56 cases of extradigital glomus tumors over a 20-year period, 20% of cases had associated trauma prior to symptom onset [35]. In another study, three out of eight patients with glomus tumors of the digits gave a history of preceding trauma [35]. The history of trauma is considered an important cause of glomus tumors [72].
Clinical Presentation and Diagnostic Challenges¶
Glomus tumors are among the most painful clinical conditions confirmed by comprehensive clinical assessment [2]. Symptoms and signs are relatively sensitive and specific when used in combination [4]. Despite this, glomus tumors of the hand are associated with prolonged diagnostic delay regardless of tumor location [5]. Early occult lesions may not be revealed by physical examination due to barely detectable symptoms [24]. These subcutaneous, mostly subungual nodules have a disproportionate negative impact despite their small size [71]. Symptoms are often unclear even when significant pain is present, leading to late diagnosis [21]. Chronic pain from glomus tumors evolves in the upper limb and causes disability and handicap [21]. Though benign, these tumors can cause decades of severe pain if misdiagnosed [10]. Glomus tumors are often misdiagnosed and subjected to different treatment options before surgical intervention [14]. Subungual glomus tumours have a characteristic clinical presentation [36]. Diagnosis is supported by a combination of magnetic resonance imaging and clinical examination [54]. Clinical evaluation of the hand requires combining patient history with a careful physical examination to pinpoint possible pathologic processes [47].
Classification¶
Pathological Morphology: Glomus tumors are classified into three distinct histological subtypes: solid glomus tumor, glomangioma, and glomangiomyoma [106]. Solid glomus tumors consist predominantly of glomus cells [106]. Glomangiomas feature glomus cells surrounding a large number of blood vessels [106]. Glomangiomyomas contain a large number of vascular smooth muscle cells [106].
Glomangioma Characteristics: Glomangiomas represent the vascular variant of the glomus tumor [73]. They are more common in extradigital sites of the hand and forearm compared to typical glomus tumors [73]. These lesions usually occur as multiple lesions [73]. Clinically, glomangiomas are usually painless and often present as areas of discoloration, lacking the typical triad of pain, distinct local tenderness, and sensitivity to cold found in glomus tumors [73]. Histologically, they are characterized by prominent cavernous spaces with interspersed glomus cells [73]. They are poorly circumscribed and resemble a cavernous haemangioma [73]. Glomangiomas may exhibit pseudomalignant features such as poor encapsulation, cellular pleomorphism, and mitosis [73].
Other Considerations: Malignant glomus tumors are rare and mandate case presentation and longitudinal analysis to guide surgical management [9]. Glomus tumors of uncertain malignant potential have been reported to demonstrate an unfavourable and aggressive clinical course despite some reports suggesting they do not metastasise [17].
Clinical Presentation¶
Pain and Symptom Characteristics¶
Glomus tumors present with focal, often debilitating pain [32] that is variable in intensity [3]. The hallmark symptom is paroxysmal pain usually elicited by tactile stimulation [57]. Symptoms are frequently unclear despite significant pain [21], and misdiagnosis can result in decades of severe suffering [10]. In some cases, the presentation mimics Type II Complex Regional Pain Syndrome (CRPS) [25] or involves atypical shoulder radiation [10]. The mean duration of symptoms prior to diagnosis is 7.2 years [32].
Physical Examination and Clinical Signs¶
Diagnosis relies on a delicate amalgam of symptoms, signs, and investigations [27], with a classic patient history and meticulous physical examination paramount enough to override inconclusive advanced imaging [10]. Clinical diagnosis is feasible based on history and examination alone [18], as symptoms and signs are relatively sensitive and specific when used in combination [4]. Superficial lesions are readily apparent on inspection due to characteristic blue-red coloration [57]. Subungual glomus tumours exhibit a characteristic clinical presentation [36].
Demographics and Epidemiology¶
Glomus tumors occur most commonly between 20 and 40 years of age with no sex predilection [57]. They represent approximately 5% of soft tissue tumors of the hand [21]. In a 10-year hand surgery referral series, the disease was encountered in 0.26% of patients (8 of 3014) [15]. A retrospective surgical pathology database indicated that the upper extremity was involved in 12/25 (48%) of cases, while the lower extremity was involved in 12/25 (48%) [32].
Anatomical Location¶
Tumors develop within the glomus neuro-myo-arterial system, mostly in the hand at the subungual region [21]. In the vast majority of cases, the tumor arises in the subungual region of the digits [57]. Glomus tumors are occasionally found in the palm and foot [57] and may appear anywhere, even at sites where the glomus body is normally absent [57]. The forearm is the most common extradigital location [39], with the frequency of extradigital cases in reported series varying from 11% to 65% [39]. One case (4%) in a retrospective database was located within the trachea [32].
Multiplicity and Associated Conditions¶
Multiple lesions occur in approximately 10% of cases [57]. Multiple digital glomus tumors are a definite entity, occurring in seven of 28 patients in one series [16]. Glomus tumor must be included in the differential diagnosis for neurofibromatosis patients presenting with a painful lesion of the hand or finger [51]. Specifically, in patients with type I neurofibromatosis presenting with a painful subcutaneous lesion, glomus tumor must be considered [53].
Diagnostic Challenges and Delay¶
Glomus tumors are associated with prolonged diagnostic delay regardless of tumor location [5]. As an uncommon soft tissue neoplasm, they may be easily dismissed by clinicians, resulting in prolonged periods before correct diagnosis [13]. A significant proportion of patients are initially diagnosed with psychiatric disorders [57]. Early diagnosis is critical to avoid lengthy treatment delays, chronic pain, disuse syndromes, and psychiatric misdiagnoses [93]. Diagnostic delay implies treatment delay, leading to amplified suffering and real disability due to high-intensity pain [19]. A high index of suspicion is necessary when tumors arise from deeper structures at unusual anatomical sites [57], highlighting the continued importance of clinical suspicion [1].
Investigations¶
Clinical Diagnosis: Clinical suspicion remains critical for diagnosing glomus tumors, particularly when magnetic resonance imaging is negative [1]. A high index of suspicion is required due to variable pain presentation [3], as these tumors are easily dismissed by clinicians, resulting in prolonged diagnostic delays [13]. Diagnosis is confirmed by comprehensive clinical assessment [2], where a classic patient history and meticulous physical examination can override inconclusive advanced imaging [10].
MRI: MRI is the most sensitive diagnostic tool for glomus tumors [96]. In a series of six patients with hand glomus tumors, MRI depicted the tumors in excellent detail, facilitating diagnosis in atypical presentations and serving as a valuable noninvasive means for early diagnosis of occult tumors [31]. MRI with a marker placed in the region of point tenderness is the best method for identifying small glomus tumors [32]. Characteristic imaging features include a small circumscribed mass at the site of point tenderness showing high T2 signal, uniform enhancement after gadolinium administration, and diffuse contrast medium enhancement [32]. MRI has also aided diagnosis in unusual locations, such as the fingertip [61]. However, MRI is not reliable for diagnosing intravenous glomus tumors [97]. Failure to diagnose glomus tumors on MRI is associated with smaller tumor size, atypical pathology, and atypical location [92]. In four cases where MRI was negative, histology confirmed glomus tumors; the lack of delineation was attributed to their small size (2–3 mm) [50].
Ultrasound: Ultrasonography shows lesions as well-circumscribed with marked vascularity on color Doppler evaluation [32]. The diagnosis is suggested by a small circumscribed mass at the site of point tenderness demonstrating marked vascularity on Doppler [32]. Ultrasound confirmed the presence and precise location of a subungual glomus tumor before surgery [66]. While user-dependent, ultrasound may be non-inferior for a sonographer familiar with subungual imaging [58]. In one case, ultrasound identified a well-defined cystic lesion with internal debris measuring 14 - 6 - 10 mm within the subcutaneous layer [35]. In the same case, the lesion was avascular, incompressible, and appeared similar to a neuroma on ultrasound [35].
Other Imaging Modalities: Various methods proposed to augment physical examination include plain x-rays, arteriograms, thermograms, and high-resolution real-time ultrasound [31]. These modalities have limitations regarding radiation exposure, operator-dependent technique, or both [31]. Three-dimensional reconstruction using multidetector computed tomography angiography illustrated the tumor, vascular branches, and bony components in a single image [68]. Imaging studies can be of little utility in distinguishing glomus tumors from other lesions, such as giant cell tumor of the tendon sheath [98].
Treatment¶
Non-Operative¶
The provided evidence base does not support conservative management as a definitive treatment strategy for glomus tumors. Surgical intervention is the established standard of care, with no evidence cited regarding the efficacy of weight loss, physical therapy, NSAIDs, or injections in curing the condition.
Operative¶
Indications: Complete surgical excision is the reference treatment and treatment of choice for glomus tumors [21, 57]. Once identified, these tumors can be effectively treated with complete excision [6]. The procedure is curative, providing immediate relief [10] and dramatically curing the condition [2]. Excision relieves symptoms in most patients [20], with an immediate effect on pain and hypersensitivity [25]. In specific cases, excision results in complete pain relief and resolution of clinical symptoms [23]. Most benign glomus tumors in children can be completely cured through surgical excision [70].
Surgical Approach / Technique: Excision of glomus tumors is curative with minimal risk of recurrence [34]. A transungual approach has resulted in the complete improvement of symptoms without recurrences [33]. The Microscopic Transungual Surgical Approach has potential efficacy in treating these tumors [99]. In a study of subungual glomus tumors, no new nail deformity was found with the transungual approach, contrary to reported literature [41]. However, neither a nail-sparing approach nor microscopic excision lowered the incidence of nail deformities in a multicentre study [69]. The current evidence on glomus tumors is limited to retrospective case series and literature reviews, with no studies comparing different surgical approaches [26].
Other Considerations: Local recurrence is rare and usually indicates inadequate excision [57]. No risk factors significantly predicted recurrence in a multicentre study of digital glomus tumours [69]. Multiple digital glomus tumors are a definite entity, occurring in seven of 28 patients in a 1979 series [16]. Multiple lesions occur in approximately 10% of cases [57]. Although some reports suggest that glomus tumours of uncertain malignant potential do not metastasise, a 2012 case demonstrated an unfavourable and aggressive clinical course [17]. Malignant transformation appears to be such a rare phenomenon that it can be disregarded from the clinical point of view [57].
Complications¶
Diagnostic Delay and Misdiagnosis: Glomus tumors are frequently dismissed by clinicians, resulting in a prolonged period before correct diagnosis is established [13]. This diagnostic delay often leads to misdiagnosis for months or even years [21]. The subsequent treatment delay amplifies suffering and can cause real disability due to high-intensity pain [19]. Symptoms are often unclear despite significant pain, degrading the patient's quality of life during the misdiagnosis period [21]. This degradation in quality of life is considered the most disabling factor of the disease [21]. A subungual tumor with a 15-year delay and atypical shoulder radiation highlights the need for heightened clinical suspicion [10]. Severe morbidity can occur with subtle clinical signs in rare presentations [11].
Atypical Presentation and Diagnostic Challenges: While the classic presentation is a painful subcutaneous nodule in a subungual or digital pulp location, atypical presentations are well documented [31]. Early occult lesions may not be revealed on physical examination, making localization for extirpation difficult [31]. Glomus tumors can present as Type II CRPS, such as a periosteal glomus tumor at the metacarpal base [25]. Extradigital cases account for 11–65% of all glomus tumor cases and are reported to be more common in men, although most subungual lesions occur in women [64]. The forearm is the most common extradigital location [64]. A glomus tumor can occasionally cause pain by directly compressing the forearm nerves [64].
Imaging and Localization: Various diagnostic methods have been proposed to augment physical examination, including plain x-rays, arteriograms, thermograms, and high-resolution real-time ultrasound [31]. All these methods have limitations regarding radiation exposure, operator-dependent technique, or both [31]. Magnetic resonance imaging (MRI) with a marker placed in the region of point tenderness is the best method for identifying small glomus tumors [32]. These tumors exhibit high T2 signal and uniform enhancement after gadolinium administration [32]. MRI proved valuable as a noninvasive and accurate means for the early diagnosis of occult glomus tumors, facilitating diagnosis in patients with atypical presentation [31]. The continued importance of clinical suspicion is highlighted, particularly when the tumor is not diagnosed on MRI [1].
Other Considerations: Glomus tumors are benign neoplasms arising from glomus bodies, which are specialized arteriovenous anastomoses serving a thermoregulatory function [43]. The first clinical description is credited to Wood in 1812, with the term "glomus" coined by Masson in 1924 [43]. These tumors are highly organized, well-differentiated, and benign [43]. The mechanism of pain production is not fully established, but the presence of substance P within nerve fibers and the neurologic control of glomus bodies may be relevant [43]. Glomus tumors account for 1-2% of soft tissue tumors of the hand [64]. In a Mayo clinic series, they accounted for 1.6% of 500 consecutive primary soft tissue tumours of the extremities [73]. Mean tumor size was 13 mm, with a mean duration of symptoms of 7.2 years [32]. The upper extremity was involved in 48% of tumors, the lower extremity in 48%, and one case (4%) was within the trachea [32]. Essentially, all glomus tumors are benign and are adequately treated by excision [45]. Infrequent cases of recurrence are probably the result of incomplete excision or missed multiple tumors [45]. On removal of the tumor, symptoms are usually completely resolved [45].
Recovery¶
Other Considerations: Complete surgical excision of glomus tumors is curative [2]. Surgical excision is associated with minimal risk of recurrence [34]. Excision through a transungual approach resulted in complete improvement of symptoms without recurrences [33]. Surgical management can improve the quality of life in patients treated for glomus tumors of the upper limb [21]. Multiple digital glomus tumors are a definite entity, occurring in seven of 28 patients in a reported series [16].
Key Evidence¶
- [L4] These findings highlight the continued importance of clinical suspicion in glomus tumor diagnosis. [1] (10.1016/j.jhsa.2014.12.002)
- [Paper] Glomus tumor is one of the most painful clinical conditions confirmed by comprehensive clinical assessment and cured dramatically by complete surgical excision. [2] (10.4103/jfmpc.jfmpc_446_20)
- [Paper] Glomus tumors can present with variable pain, and a high index of suspicion is needed for diagnosis. [3] (10.7759/cureus.30038)
- [Paper] Although glomus tumours are uncommon tumours, symptoms and signs are relatively sensitive and specific when used in combination. [4] (10.5999/aps.2013.40.5.492)
- [Paper] Glomus tumors of the hand are associated with prolonged diagnostic delay regardless of tumor location. [5] (10.7759/cureus.107434)
- [Paper] Once identified, glomus tumors can be effectively treated with complete excision. [6] (10.7759/cureus.86227)
- [L5] A high clinical suspicion is of primary importance when dealing with these lesions, and patients should be counseled before surgery regarding the possibility of multiple glomus tumors. [7] (10.1016/j.jhsa.2004.09.008)
- [L4] Familiarity with extradigital glomus tumors will enable hand surgeons to provide patients with long-term relief from this unusual problem. [8] (10.1016/j.jhsa.2017.07.025)
- [L4] The rare nature of malignant glomus tumors mandates case presentation and longitudinal analysis to help guide surgical management and optimize outcomes. [9] (10.1177/1558944715614874)
- [Paper] [10] (10.1002/ccr3.71849)
- [Paper] We report this case for the rare presentation of glomus tumour (severe morbidity with subtle clinical signs). [11] (10.4103/0974-2077.146683)
- [L5] The diagnosis of glomus tumor is primarily clinical because imaging techniques do not give a specific image of the tumor. [12] (10.1016/s1058-2746(02)00029-0)
- [L4] Glomus tumour is an uncommon soft tissue neoplasm that commonly occurs in the extremities and may be easily dismissed by clinicians, resulting in a prolonged period before the right diagnosis is made. [13] (10.1186/s13018-023-04234-1)
- [L4] Glomus tumours are often misdiagnosed and are intervened with different treatment options before being surgically intervened. [14] (10.4103/jwas.jwas_171_22)
- [L4] Glomus tumor is a rare disease, encountered in 0.26% of patients (8 of 3014) referring for hand surgery over a 10-year period. [15] (10.1097/bth.0b013e3181c767d4)
- [L4] Multiple digital glomus tumors are a definite entity, occurring in seven of 28 patients in this series. [16] (10.1016/s0363-5023(79)80076-3)
- [L5] Although some reports suggest that glomus tumours of uncertain malignant potential do not metastasise, this case demonstrates an unfavourable and aggressive clinical course. [17] (10.1136/bcr-2012-007618)
- [Paper] Diagnosis of glomus tumours can be made clinically based on history taking and clinical examination. [18] (10.5704/moj.1703.020)
- [Paper] Although the glomus tumor is a rare lesion, we need to be familiar with it because a diagnostic delay also implies a treatment delay which will lead to amplified suffering and even real disability due to the high-intensity pain in these cases. [19] (10.47162/rjme.62.1.23)
- [Case_report] Excision of the tumor relieves symptoms in most patients, but clinicians should search for synchronous glomus tumors during excision to avoid recurrence or persistence of symptoms due to undiscovered multiple lesions. [20] (10.1016/j.jhsa.2013.07.024)
- [L4] [21] (10.1016/j.main.2014.07.001)
- [Paper] Early occult lesions of glomus tumor in the hand may not be revealed by physical examination because of their barely detectable symptoms. [24] (10.5999/aps.2013.40.4.392)
- [Case_report] Excision of symptomatic glomus tumors has an immediate effect on pain and hypersensitivity. [25] (10.1177/1558944719895618)
- [L4] The evidence on glomus tumor is limited to retrospective case series and literature reviews, with no studies comparing different surgical approaches. [26] (10.1016/j.jhsa.2011.10.026)
- [Paper] The diagnosis of a glomus tumor is a delicate amalgam of symptoms, signs, and investigations. [27] (10.4103/idoj.idoj_1186_24)
- [L4] [31] (10.1016/0363-5023(92)90353-q)
- [L4] [32] (10.1007/s00256-010-1067-1)
- [Paper] Excision of glomus tumors through a transungual approach resulted in the complete improvement of symptoms without recurrences. [33] (10.1016/j.jpra.2020.09.004)
- [Paper] Surgical excision of glomus tumors was curative with minimal risk of recurrence. [34] (10.4103/idoj.idoj_786_24)
- [L4] [35] (10.1177/1758573216640190)
- [Paper] Subungual glomus tumours have characteristic clinical presentation. [36] (10.4103/0974-2077.123401)
- [L5] The frequency of extradigital cases reported in these series varied from 11% to 65%, with the forearm noted to be the most common extradigital location. [39] (10.1016/s0266-7681(05)80105-6)
- [L4] Glomus tumors about the wrist area are rare. [40] (10.1016/s0363-5023(83)80095-1)
- [Paper] Contrary to reported literature, we did not find the development of any new nail deformity with this approach. [41] (10.4103/0019-5413.159611)
- [L5] The treatment of choice for glomangiosarcomas is wide local excision. [42] (10.1016/s0363-5023(97)80057-3)
- [L5] [43] (10.1016/s1058-2746(99)90162-3)
- [L4] In principle, glomangiomas are benign; they develop from the glomus body and occur especially in the fingers (subungual). [44] (10.1007/bf00932451)
- [L5] [45] (10.1016/s0363-5023(09)91114-5)
- [Paper] The retrospective study of 11 patients with glomus tumors of the hand showed a mean age of 36.27 years and a mean follow-up of 34.40 months. [46] (10.11604/pamj.2016.24.262.8154)
- [L4] The four cases in which the MRI was negative all proved histologically to be glomus tumours, and the lack of delineation was attributed to their small size (2–3 mm). [50] (10.1016/j.jhsb.2005.06.009)
- [L3] Glomus tumor should be included in the differential diagnosis in neurofibromatosis patients who present with a painful lesion of the hand or finger. [51] (10.1016/j.jhsa.2013.05.025)
- [Paper] In the patient with type I neurofibromatosis who presents with a painful subcutaneous lesion, the diagnosis of glomus tumor must be considered. [53] (10.1097/gox.0000000000000144)
- [L5] A combination of magnetic resonance imaging and clinical examination is used to support the diagnosis. [54] (10.1016/j.jhsa.2006.05.018)
- [L5] [57] (10.1067/mse.2000.108961)
- [Paper] US is user-dependent and may be non-inferior for a sonographer familiar with subungual US. [58] (10.1159/000530397)
- [L5] Magnetic resonance imaging has been shown to help in the diagnosis of a glomus tumor in an unusual location in a fingertip. [61] (10.1016/0363-5023(90)90072-y)
- [Paper] [64] (10.1155/2014/619490)
- [L5] Ultrasonography confirmed the presence and precise location of a subungual glomus tumour before surgery. [66] (10.1016/0266-7681(93)90235-8)
- [Paper] Three-dimensional reconstruction illustrated the tumor, vascular branches, and bony components in a single image. [68] (10.5021/ad.2015.27.2.226)
- [L4] No risk factors significantly predicted recurrence, and neither a nail-sparing approach nor microscopic excision lowered the incidence of nail deformities. [69] (10.1177/1753193418774176)
- [Paper] Although glomus tumors in children are extremely rare, most are benign and can be completely cured through surgical excision. [70] (10.1002/ccr3.72907)
- [L4] These subcutaneous, mostly subungual, nodules, with predominance on the ring finger, have a disproportionate negative impact despite their small size. [71] (10.1016/j.hansur.2017.04.002)
- [Paper] The history of trauma is an important cause of GTs, and the most common site of extra-subungual tissue is the knee, especially in young adults. [72] (10.21037/atm-20-6998)
- [L4] [73] (10.1054/jhsb.1998.0013)
- [L4] Failure to diagnose glomus tumors on MRI is associated with smaller tumor size, atypical glomus tumor pathology, and atypical location. [92] (10.1016/j.jhsa.2014.06.096)
- [Paper] Early diagnosis of glomus tumors is important to avoid lengthy treatment delays, chronic pain, disuse syndromes, and psychiatric misdiagnoses. [93] (10.4103/jfmpc.jfmpc_88_19)
- [Paper] MRI is the most sensitive diagnostic tool for glomus tumors. [96] (10.11604/pamj.2017.26.155.11899)
- [L5] Unlike extradigital glomus tumors, magnetic resonance imaging is not reliable in diagnosing intravenous glomus tumors. [97] (10.1177/1558944716675296)
- [Case_report] Imaging studies can be of little utility in distinguishing glomus tumors from other lesions like giant cell tumor of the tendon sheath. [98] (10.1016/j.jhsa.2012.02.035)
- [Paper] Our study suggests the potential efficacy of the Microscopic Transungual Surgical Approach in treating glomus tumors. [99] (10.3389/fmed.2025.1607299)
- [Paper] [106] (10.1016/j.abd.2023.03.005)
See Also¶
References¶
[1] Characteristics of Glomus Tumors in the Hand Not Diagnosed on Magnetic Resonance Imaging. The Journal of Hand Surgery. 2015. DOI: 10.1016/j.jhsa.2014.12.002
[2] Digital glomus tumor: An experience of 57 cases over 20 years. Journal of Family Medicine and Primary Care. 2020. DOI: 10.4103/jfmpc.jfmpc_446_20
[3] Hand and Foot Glomus Tumors: Significance of MRI Diagnosis Followed by Histopathological Assessment. Cureus. 2022. DOI: 10.7759/cureus.30038
[4] Where is the Lesion? Glomus Tumours of the Hand. Archives of Plastic Surgery. 2013. DOI: 10.5999/aps.2013.40.5.492
[5] Diagnostic Delay and Clinical Characteristics of Glomus Tumors in the Hand: A Case Series of 11 Patients. Cureus. 2026. DOI: 10.7759/cureus.107434
[6] Management of Glomus Tumors: Experience From a Tertiary Care Centre in India. Cureus. 2025. DOI: 10.7759/cureus.86227
[7] Multiple occurrences of different histologic types of the glomus tumor. The Journal of Hand Surgery. 2005. DOI: 10.1016/j.jhsa.2004.09.008
[8] An Extradigital Glomus Tumor of the Median Antebrachial Vein. The Journal of Hand Surgery. 2018. DOI: 10.1016/j.jhsa.2017.07.025
[9] Malignant Glomus Tumors of the Hand. HAND. 2016. DOI: 10.1177/1558944715614874
[10] Unmasking the Silent Glomus Tumor of the Index Finger—A Case Report and Literature Review. Clinical Case Reports. 2026. DOI: 10.1002/ccr3.71849
[11] Unusual location of glomus tumour on the right ring finger. Journal of Cutaneous and Aesthetic Surgery. 2014. DOI: 10.4103/0974-2077.146683
[12] Extradigital glomus tumor of the triceps tendon as a cause of elbow pain: a case report. Journal of Shoulder and Elbow Surgery. 2003. DOI: 10.1016/s1058-2746(02)00029-0
[13] Glomus tumour: an institutional experience of 31 cases. Journal of Orthopaedic Surgery and Research. 2023. DOI: 10.1186/s13018-023-04234-1
[14] Glomus Tumour of Hand––A Commonly Misdiagnosed Pathology. Journal of West African College of Surgeons. 2022. DOI: 10.4103/jwas.jwas_171_22
[15] Diagnosis and Management of Glomus Tumors of the Hand. Techniques in Hand & Upper Extremity Surgery. 2010. DOI: 10.1097/bth.0b013e3181c767d4
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