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Outcomes & Research
Elbow outcomes research: PROMs, UCLR trends in MLB, and value-based care metrics for shoulder arthroplasty & elbow reconstruction.

Overview¶
Future objective, outcome-based, and comparative studies are required to evaluate optimal treatment modalities for multi-ligament injured knees before evidence-based recommendations can be established [1]. Similarly, comparative studies must utilize appropriate outcome measures with adequate sample sizes to provide meaningful results in shoulder arthroplasty outcomes [28]. Further research is needed to assess larger patient cohorts and compare outcomes to size-matched approaches for the arthroscopic treatment of off-track Hill-Sachs lesions using fresh osteochondral allograft plugs [30].
Evidence-based clinical practice guidelines, appropriate use criteria, outcome measures, and patient-reported outcome measures are critical tools to ensure the best clinical care and will be increasingly integrated into care pathways [2]. Developing a core outcome set would allow for more effective comparison across studies in systematic reviews of shoulder arthroplasty [4]. Factors leading to impactful conclusions and clinical change include the role of outcome selection, study design, presentation of results, and stakeholder involvement [12].
Case series on the use of elbow arthroscopy for management of the pediatric elbow have demonstrated significant improvements in functional outcomes and low rates of major complications [13]. Evidence surrounds several potential indications for elbow arthroscopy in the pediatric population beyond osteochondritis dissecans [13]. Heterogeneity in implant type, patient characteristics, and outcome measures, along with inadequate reporting of study details, restricts definitive conclusions in functional outcomes post-radial head arthroplasty [7]. The patients' characteristics and indications for surgery were not described in a majority of clinical outcome studies of rotator cuff repair [11].
Orthopaedic registry studies differ from randomized controlled trials in many ways and offer certain advantages, requiring an understanding of the strengths and limitations of both registry cohort studies and RCTs to properly evaluate the literature [31]. Artificial intelligence analysis of biomedical, large, clinical registry data using machine learning requires tens of thousands of subjects and a focus on substantial clinical benefit, as the minimal clinically important difference is too low a bar [5]. Registries should include validated patient-reported outcome scores and measures of clinical relevance and expectations [5].
Anatomy & Pathophysiology¶
Kinematics and Stability¶
The most common mechanism of acute elbow dislocation involves a valgus moment to an extended elbow, suggesting some dislocations result from acute valgus instability and are distinct from posterolateral rotatory instability [86]. Repetitive pitching (100 balls) induces a significant reduction in the dynamic stabilizing ability of the medial elbow against valgus laxity in high school baseball players [90].
Normative Values and Pain Effects¶
Elbow range of motion is influenced by age, sex, and BMI [83]. Normative values for isometric elbow strength exhibit large standard deviations and lack consensus on measurement devices and positions, requiring cautious interpretation [91]. Pain originating from the long head of the biceps tendon induces an approximately 30% decrease in shoulder abduction and elbow flexion strength despite the absence of structural or biomechanical abnormalities [95].
Pathologic Classification¶
A pathologic classification for elbow stiffness provides a new perspective on the understanding and standardization of elbow arthrolysis [22].
Classification¶
Evidence-based clinical practice guidelines, appropriate use criteria, outcome measures, and patient-reported outcome measures are critical tools to ensure the best clinical care for patients and will be increasingly integrated into care pathways [2]. Developing a core outcome set allows for more effective comparison across studies in systematic reviews [4] and helps standardize outcome reporting to ensure future research is relevant, interpretable, and amenable to systematic review and/or meta-analysis [6].
Elbow Stiffness: A proposed pathologic classification for elbow stiffness provides a new perspective on the understanding and standardization of elbow arthrolysis, providing satisfactory clinical outcomes [22].
Greater Trochanteric Pain Syndrome (GTPS): An intraoperative classification system and treatment algorithm for surgical treatment of various GTPS types yields favorable patient-reported outcomes [43].
Knee Replacement: Several countries' Diagnosis-Related Groups (DRG) systems for knee replacement might be improved through the introduction of classification variables for revision of knee replacement or for the presence of complications or comorbidities [47].
Shoulder Arthroplasty: Alternative glenoid classification systems or predictive models should be considered to provide more precise prognoses for patients before and after shoulder arthroplasty performed for osteoarthritis with an intact rotator cuff [59].
Meniscal Extrusion: Integrating dynamic factors and clinical outcomes in MRI-based classifications informs treatment approaches for meniscal extrusion [8].
FEDS Categories: Different Frequency, Etiology, Direction, and Severity (FEDS) categories showed varying degrees of improvement and failure rates, indicating that the system can be used to provide prognostic insight for presurgical education [67].
Other Considerations: Heterogeneity in the type of implant, patient characteristics, and outcome measures used, along with inadequate reporting of study details, restricts definitive conclusions in functional outcomes post-radial head arthroplasty [7]. The first requirement to make progress in the field of upper-extremity musculoskeletal disorders is to agree on unambiguous terminology and classification [74]. Comprehensive registries collecting information on orthopaedic injuries, treatment, complications, and outcomes are required to characterize trauma, evaluate treatment options, and improve care and outcomes [76]. Registries should include validated patient-reported outcome scores and measures of clinical relevance and expectations [5]. Epidemiology and non-epidemiology-trained reviewers can apply the levels-of-evidence guide to published studies with acceptable interobserver agreement, though the validity of this system remains a question for future research [66]. The Musculoskeletal Outcomes Data Evaluation and Management System achieved its goal regarding the development of validated questionnaires, but the data collection component did not [73].
Clinical Presentation¶
Assessment Frameworks: Evidence-based clinical practice guidelines, appropriate use criteria, outcome measures, and patient-reported outcome measures are critical tools for ensuring best clinical care and are increasingly integrated into care pathways [2].
Outcome Standardization: Development of a core outcome set helps standardize outcome reporting in Dupuytren’s disease research, ensuring future research is relevant, interpretable, and amenable to systematic review or meta-analysis [6]. A combination of generic patient reported outcomes, a disease-specific questionnaire, and physical measures using standardised protocols should be used for future outcomes studies in Dupuytren’s disease [15]. Standardizing outcomes reporting facilitates comparisons across the literature and improves understanding of the prognosis for superior labrum anterior and posterior tears [16]. There has been a demonstrated increase in core outcome sets developed for both research and routine practice, with consistently high inclusion of patient participants [44].
Patient-Reported Outcome Measures (PROMs): Patient-reported outcomes are highly useful when they inform other relevant outcomes, such as predicting return to sport, and psychological factors are potentially modifiable, allowing for early identification and intervention to improve final outcomes [33]. Only 57% of primary medical providers use patient reported outcome measures within their practice, with the information largely used for research rather than clinical decision-making [36]. Before developing or translating a new patient-reported outcome, researchers should review existing measures to determine if one already suits clinical or research needs, as new PROs should only be developed for constructs with no existing measures or for specific needs like faster completion [38]. The Persian version of the international knee documentation committee subjective knee form (IKDC-SF) demonstrates strong psychometric performance across subgroups and clinically meaningful change thresholds, supporting its use in both clinical and research settings [39]. Failure to attempt a return to sport after hip arthroscopy does not equate to a poor clinical outcome, as patients can still experience statistically significant and clinically meaningful improvements in patient-reported outcome measures [40].
Registry and Data Requirements: Artificial intelligence analysis of biomedical large clinical registry data requires tens of thousands of subjects and a focus on substantial clinical benefit, as the minimal clinically important difference is considered too low a bar [5]. Registries should include validated patient-reported outcome scores and measures of clinical relevance and expectations [5].
Diagnostic and Classification Integration: Integrating dynamic factors and clinical outcomes in MRI-based classifications supports informing treatment approaches for meniscal extrusion [8]. Prognostic subgrouping reveals more diverse patterns in pain and function recovery over 1 year than traditional diagnostic groups, potentially better reflecting the diversity in recovery of common musculoskeletal disorders [42].
Clinical Discrepancies and Follow-up: Discrepancies in patient-reported outcomes exist, with patients declining enrolment in trials investigating weight loss versus knee arthroplasty reporting more severe symptoms than those accepting participation [32]. Patients with giant cell tumour should be followed indefinitely and referred promptly if new symptoms, particularly pain, emerge [45].
Research Gaps and Methodology: Future objective outcome-based and comparative studies are needed to evaluate optimal treatment modalities for multi-ligament injured knees before evidence-based recommendations can be made [1]. Larger and long-term controlled trials are needed to support the clinical effectiveness of autologous bone marrow stem cell implantation for osteonecrosis of the knee in sickle cell disease [3]. There is a need for consistent and transparent reporting of outcomes when treating complex cases, such as two-stage revisions for periprosthetic joint infections [41]. Factors leading to impactful conclusions and clinical change include the role of outcome selection, study design, presentation of results, and stakeholder involvement [12].
Investigations¶
MRI: Integrating dynamic factors and clinical outcomes into MRI-based classifications can inform treatment approaches for meniscal extrusion [8]. The MRI-based BOGIE score correlates with early clinical function after autologous osteochondral grafting for osteochondritis dissecans of the capitellum and may be useful as an adjunct tool in decision making on activity progression for this condition [61]. A reliable 6-stage MRI-based classification addressing ulnar collateral ligament (UCL) tear grade and location may confer decision making between operative and nonoperative management of UCL tears [81]. Postoperative MRI findings reflect clinical outcomes in arthroscopic debridement for refractory lateral epicondylitis, with improvement of tendinopathy area being 60% in recovered versus 16% in unrecovered groups [68]. Improvements in MRI scores followed and continued longer than improvements assessed by clinical scores after platelet-rich plasma injection in patients with lateral epicondylitis [35].
Plain Radiography: Radiographic angles of total knee arthroplasty using true unrestricted kinematic alignment are sparsely and inconsistently reported [20]. Radiographic osteoarthritis was correlated with higher failure rates, increased conversion to total hip arthroplasty, and worse outcomes after surgical management of femoroacetabular impingement [84]. Radiographic predictors for failure in surgical hip dislocation for femoroacetabular impingement were related to over- and undertreatment of acetabular rim trimming [85]. Correlation of retrieval findings with radiographic and clinical data may help establish predictors of prostheses at risk for failure in revision reverse total shoulder arthroplasty [89].
CT: Ongoing assessment using additional X-rays, computed tomography scans, or other diagnostic tests is recommended for effective monitoring of patients experiencing pain or limited range of motion after primary anatomic and reverse total shoulder arthroplasty [65].
Other Considerations: Future objective outcome-based studies and comparative studies are needed to evaluate optimal treatment modalities for operative management of the medial collateral ligament in multi-ligament injured knees [1]. A longer follow-up period is required to determine the influence of radiological findings on final outcomes in total knee arthroplasty comparing cemented versus uncemented femoral components [17]. Different alignment strategies are often grouped under the umbrella term of kinematic alignment, contributing to conflicting reports and unresolved questions regarding the efficacy of true unrestricted kinematic alignment [20]. Comparing clinical outcomes between different modalities should consider not only statistically significant differences but also the minimal clinically important difference (MCID) [71].
Treatment¶
Non-Operative¶
Non-operative management is effective for a majority of adolescent patients with femoroacetabular impingement syndrome (FAI), with significant improvements in patient-reported outcomes (PROs) persisting at a mean 5-year follow-up [77]. Arthroscopic treatment and corticosteroid injection both demonstrate clinical effects in the management of FAI [23]. For partial anterior cruciate ligament rupture, non-operative treatment is justified as it yields good results in the majority of patients, although a substantial number will aggravate their injury over time [82]. In lumbar spinal stenosis, surgery reduces pain and disability better than nonoperative treatment, with effectiveness sustained over 2 years [48]; however, objective measures of walking ability improved in both operative and nonoperative groups, with no statistical difference between the two [48]. The overall incidence of regression is 63% among non-surgically treated symptomatic lumbar disc herniation patients [25]. Non-operative management of hip and knee osteoarthritis using PROs requires further research to clarify effects on patient outcomes [52].
Operative¶
Indications: Obesity is not a contraindication to unicompartmental knee arthroplasty (UKA) provided other patient selection criteria are adhered to [34]. Low and high body mass index, along with lower numbers of screws in the articular segment, are risk factors for non-union of distal humeral fractures in the elderly [69]. Non-union is associated with poor clinical outcomes in this population [69]. Patients failing conservative treatment report good outcomes following surgical treatment of trapezius palsy [70]. Custom hemiarthroplasty appears to be a reasonable method to salvage proximal humeral dysplasia epiphysealis hemimelica when nonsurgical management has failed to provide relief [92]. Total elbow arthroplasty in juvenile idiopathic arthritis patients provides long-term benefit with satisfactory clinical outcomes and implant durability [10].
Surgical Approach / Technique: Operative treatment of full-thickness rotator cuff tears resulted in greater improvement in Constant scores and significantly decreased pain scores compared to nonoperative management [72].
Implant Selection: Heterogeneity of implant type, patient characteristics, and outcome measures, along with inadequate reporting of study details, restricts definitive conclusions regarding functional outcomes post-radial head arthroplasty [7].
Adjuncts: Limited evidence supports bone marrow aspirate concentrate as an additive to bone marrow stimulation for osteochondral lesions of the talus [37]. Until sufficiently powered, patient- and researcher-blinded, prospective randomised controlled trials are conducted, authors advise not to implement bone marrow aspirate concentrate therapy for osteochondral lesions of the talus without clinical evidence justifying the additional costs [37]. Larger and long-term controlled trials are needed to support the clinical effectiveness of autologous bone marrow stem cell implantation for osteonecrosis of the knee in sickle cell disease [3].
Other Considerations: Future objective outcome-based and comparative studies are needed to evaluate the optimal treatment modality for the medial collateral ligament in multi-ligament injured knees [1]. Evidence-based clinical practice guidelines, appropriate use criteria, outcome measures, and patient-reported outcome measures are critical tools to ensure the best clinical care for patients [2]. Developing a core outcome set would allow for more effective comparison across studies in systematic reviews of shoulder arthroplasty research [4]. Development of a core outcome set will help standardize outcome reporting and ensure future research in Dupuytren’s disease is relevant, interpretable, and amenable to systematic review and/or meta-analysis [6]. A combination of generic patient reported outcomes, a disease-specific questionnaire, and physical measures using standardised protocols should be used for future outcomes studies on Dupuytren’s disease [15]. Patients' characteristics and indications for surgery were not described in a majority of clinical outcome studies of rotator cuff repair [11]. Outcome evaluation is a systematic and objective procedure to determine the impact and success of a therapeutic program, focusing on the patient's well-being in daily life [46]. Understanding what constitutes a real-world benefit from treatment is key to designing and critically appraising clinical research [50]. Non-responders to patient-reported outcomes in hip and knee arthroplasty had significantly increased mortality and significantly worse baseline scores despite similar demographics and revision risk [63]. Findings point to a lack in robustness for conclusions drawn from randomized controlled trials relating to nonoperative treatment for lateral epicondylitis, where a reversal of only 3 patient outcomes could considerably influence reported statistically significant findings [54]. No evidence exists on outcomes following non-operative management of femoroacetabular impingement with concomitant Tönnis Grade 2 or more hip osteoarthritis [78]. Expanded indications or changing surgical preferences are possible reasons for trends in the surgical treatment of cubital tunnel syndrome [29]. The overall decrease in anterior cruciate ligament tears, anterior cruciate ligament reconstruction, and nonoperative management found in the United States from 2010 to 2020 is a reversal from trends reported in the literature from previous decades [88].
Complications¶
Nerve palsy: Distal peripheral neuropathy develops as a new onset complication in 14.6% of previously asymptomatic patients undergoing arthroscopic rotator cuff repair, with 91.7% of those cases resolving by 3 months [27].
Shoulder Arthroplasty Complications: Anatomic total shoulder arthroplasty in patients younger than 50 years of age is associated with moderately inferior functional outcomes and long-term survivorship compared to older patients [18]. A history of prior implant complication is the most important patient feature for predicting complications and unplanned readmission following primary anatomic total shoulder replacements [98]. Patients undergoing shoulder surgery with a history of cervical spine conditions have increased rates of surgical complications compared to patients without dual shoulder-cervical spine pathology [93]. Surgeon experience significantly modifies patient selection, results, and complications for reverse shoulder arthroplasty [106]. The stemless reverse total shoulder arthroplasty design implant is associated with a low complication rate and good early clinical outcomes [96].
Elbow Arthroplasty Complications: Complication rates remain high for linked total elbow replacement systems despite design advances [99].
Hand Surgery Complications: Postoperative complication rates for distal biceps tendon repair are similar to prior studies, although the true rate of rerupture may be higher than previously thought [103]. Major complications occur at roughly half the rate in the staged group compared to the single-stage group for fasciectomy in severe PIPJ contractures in Dupuytren disease, although the study was underpowered for complication analysis [104].
Other Considerations: Autologous bone marrow stem cell implantation for osteonecrosis of the knee in sickle cell disease requires larger and long-term controlled trials to support its clinical effectiveness [3].
Recovery¶
Light activity (weeks): Specific timelines for light activity are not defined in the current evidence base. However, early functional status changes are observed between 1- and 2-year follow-up assessments following hip arthroscopy, where 21.5% of patients improved and 18.6% declined in self-reported functional status [51].
Full activity (months): Long-term functional outcomes vary by procedure and patient age. Patients under 50 years of age undergoing anatomic total shoulder arthroplasty may expect moderately inferior functional outcomes and long-term survivorship compared to older patients [18]. Conversely, minimally invasive Oxford unicompartmental knee arthroplasty ensures excellent functional outcome and high survivorship in the long term [49]. Total elbow arthroplasty with the Discovery Elbow System resulted in improved function, reduced pain, and high patient satisfaction at a 4-year mean follow-up [9].
Complete recovery / outcome plateau (months): Final outcomes for certain interventions require extended observation. A longer follow-up period is required to determine the influence of radiological findings on final outcome for cemented versus uncemented femoral components in total knee arthroplasty [17]. Further studies with long-term follow-up are needed to determine whether the grafted area maintains structural and functional integrity after Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee [53]. For distal biceps short head tears, good outcomes are achieved with acute and delayed reconstruction, though the natural history is poor akin to complete tears [26].
Rehabilitation protocol: Functional ability and health-related quality of life improved after rehabilitation in a structured national rehabilitation program for patients with musculoskeletal disorders [62]. For revision rotator cuff repair, short-term clinical outcomes were similar to primary rotator cuff repair [60].
Functional milestones: Outcomes reporting requires standardization. Standardization of outcomes reporting for superior labrum anterior and posterior tears is needed to facilitate comparisons across the literature and improve understanding of prognosis [16]. In the context of chondrosarcoma of the pelvis and upper end of the femur, a ten or fifteen-year survival rate is more meaningful than a five-year rate for assessing cure [114]. Lesser improvements in survival have been seen in patients with metastatic or recurrent Ewing sarcoma family of tumors compared to those with localized disease [115].
Other Considerations: Several procedural and demographic factors influence recovery trajectories. Autologous bone marrow stem cell implantation for osteonecrosis of the knee in sickle cell disease requires larger and long-term controlled trials to support its clinical effectiveness [3]. Prospective, long-term observational studies are needed to understand the natural history of early post-traumatic osteoarthritis before formulating and studying interventions [24]. Longitudinal studies require continued contact and evaluation of patients for many years after the administration of treatment, and every reasonable effort should be made to obtain information on all patients in a study to ensure meaningful data [111].
Total elbow arthroplasty provides long-term benefit with satisfactory clinical outcomes and implant durability in patients with juvenile idiopathic arthritis [10]. Total elbow arthroplasty offers satisfactory clinical outcomes at long-term follow-up, with relatively stable revision and complication rates compared to short and medium term [19]. Early reimplantation (abbreviated two-stage) provides similar outcomes to traditional two-stage exchange, though optimal timing and selection criteria remain undefined [112]. Patients with a preoperative duration of symptomatic medial knee overload/arthritis of two years or greater do not experience inferior patient-reported outcomes or clinical outcomes than patients with a symptom duration of less than 2 years at mid-term follow-up [113]. Mobile and fixed-bearing (all-polyethylene tibial component) total knee arthroplasty designs functioned equivalently at the time of early follow-up in a low-to-moderate-demand patient group [116].
Non-surgical management of lumbar disc herniation shows an overall incidence of regression of 63% among symptomatic patients [25]. Following arthroscopic rotator cuff repair, 14.6% of previously asymptomatic patients develop new onset distal peripheral neuropathy, but 91.7% of those experience resolution by 3 months [27].
Key Evidence¶
- [L4] Future objective outcome-based studies as well as comparative studies are needed to further evaluate the optimal treatment modality before evidence-based recommendations can be made. [1] (10.1007/s00167-009-0810-4)
- [L4] Larger and long-term controlled trials are needed to support its clinical effectiveness. [3] (10.1186/s12891-018-2067-x)
- [L2] Developing a core outcome set would allow for more effective comparison across studies in systematic reviews. [4] (10.1371/journal.pone.0187865)
- [L5] Registries should include validated patient-reported outcome scores and measures of clinical relevance and expectations. [5] (10.1016/j.arthro.2023.10.035)
- [L1] Development of a core outcome set will help standardize outcome reporting, and ensure future research in this field is relevant, interpretable, and amenable to systematic review and/or meta-analysis. [6] (10.1177/1753193420903624)
- [L4] The heterogeneity of type of implant, patient characteristics and outcome measures used, along with an inadequate reporting of study details, restrict any definitive conclusions being made. [7] (10.1177/1758573214524934)
- [L4] Results also support integrating dynamic factors and clinical outcomes in MRI-based classifications to inform treatment approaches. [8] (10.1002/ksa.12183)
- [L4] The Discovery Elbow System resulted in improved function, reduced pain, and high patient satisfaction. [9] (10.1016/j.jse.2014.08.013)
- [L4] However, most benefit from the intervention for a long term with satisfactory clinical outcomes and implant durability. [10] (10.1016/j.jse.2014.03.012)
- [L3] The patients' characteristics and indications for surgery were not described in a majority of clinical outcome studies of rotator cuff repair. [11] (10.1007/s11999-008-0585-9)
- [Paper] The purpose of this review is to discuss which factors lead to impactful conclusions and clinical change, including the role of outcome selection, study design, presentation of results, and stakeholder involvement. [12] (10.1016/j.injury.2019.10.082)
- [L1] Case series published to date have demonstrated significant improvements in functional outcomes and low rates of major complications, with evidence surrounding several potential indications beyond osteochondritis dissecans. [13] (10.1016/j.arthro.2021.01.047)
- [L1] A combination of generic patient reported outcomes, a disease-specific questionnaire, and physical measures using standardised protocols should be used for future outcomes studies. [15] (10.1186/1471-2474-14-131)
- [L4] Efforts to standardize outcomes reporting would facilitate comparisons across the literature and improve our understanding of the prognosis of this injury. [16] (10.1016/j.jse.2016.04.020)
- [L1] A longer follow-up period is required to determine the influence of radiological findings on final outcome. [17] (10.1007/s00167-010-1347-2)
- [L4] Compared to older patients, those under 50 may expect moderately inferior functional outcomes and long-term survivorship. [18] (10.1016/j.jse.2025.09.005)
- [L4] Our systematic review established that TEA offers patients satisfactory clinical outcomes at long-term follow-up, with relatively stable revision and complication rates compared to short and medium term. [19] (10.1016/j.jse.2020.11.014)
- [L1] Different alignment strategies are often grouped under the umbrella term of kinematic alignment, which contributes to conflicting reports, confusion and unresolved questions regarding the efficacy of true unrestricted kinematic alignment. [20] (10.1002/ksa.12494)
- [L4] Our systematic review established that RHA results in satisfactory clinical outcomes and modest complication and revision rates at long-term follow-up, despite high levels of radiologic degenerative changes over the same period. [21] (10.1016/j.jse.2021.03.142)
- [L4] This study suggests that the proposed pathologic classification provides a new perspective on the understanding and standardization of elbow arthrolysis, providing satisfactory clinical outcomes. [22] (10.1016/j.jse.2019.08.001)
- [L1] AT and CT both can have clinical effects when facing FAI. [23] (10.1186/s13018-022-03187-1)
- [L5] The conference identified critical gaps between laboratory and clinical investigations, emphasizing the need for prospective, long-term observational studies to understand the natural history of early post-traumatic osteoarthritis before formulating and studying interventions. [24] (10.1177/0363546511411654)
- [L1] The overall incidence of regression is 63% among non-surgically treated symptomatic lumbar disc herniation patients. [25] (10.1186/s12891-020-03548-z)
- [L4] They present acutely, have a poor natural history akin to complete tears, and have good outcomes with acute and delayed reconstruction. [26] (10.1016/j.jse.2020.04.038)
- [L2] Additionally, 14.6% of previously asymptomatic patients develop new onset DPN, but 91.7% of those also experience resolution by 3 months. [27] (10.1016/j.jse.2016.12.039)
- [L1] Comparative studies need to use appropriate outcome measures with adequate sample sizes to provide meaningful results. [28] (10.1016/j.jse.2024.11.029)
- [L3] Possible reasons include expanded indications or changing surgical preferences. [29] (10.1016/j.jhsa.2013.04.044)
- [L4] Further research is needed to assess larger patient cohorts and compare outcomes to size-matched approaches. [30] (10.1016/j.jse.2024.06.008)
- [L3] Orthopaedic registry studies differ from randomized controlled trials in many ways and offer certain advantages; the strengths and limitations of registry cohort studies and RCTs must be understood to properly evaluate the literature. [31] (10.2106/jbjs.n.01332)
- [L4] We observed discrepancies in patient-reported outcomes, with those who declined enrolment reporting more severe symptoms. [32] (10.1002/ksa.12546)
- [L5] Patient-reported outcomes are highly useful when they inform other relevant outcomes, such as predicting return to sport, and psychological factors are potentially modifiable, allowing for early identification and intervention to improve final outcomes. [33] (10.1016/j.arthro.2022.11.028)
- [L4] Improvements in the MRI scores followed and continued longer than improvements assessed by the clinical scores. [35] (10.1016/j.jse.2022.01.147)
- [L4] Only 57% of primary medical providers are using patient reported outcome measures within their practice, with the information largely used for research rather than clinical decision-making. [36] (10.1177/2325967119s00107)
- [L1] Until sufficiently powered, patient- and researcher-blinded, prospective randomised controlled trials are conducted, the authors advise not to implement this therapy without clinical evidence that justifies the additional costs. [37] (10.1007/s00167-023-07651-1)
- [L5] Before developing or translating a new patient-reported outcome (PRO), researchers should review existing measures to determine if one already suits the clinical or research needs, as new PROs should only be developed for constructs with no existing measures or for specific needs like faster completion. [38] (10.1016/j.jht.2015.01.010)
- [L3] Its strong psychometric performance across subgroups and clinically meaningful change thresholds supports its use in both clinical and research settings. [39] (10.1016/j.jisako.2025.101053)
- [L5] Failure to attempt a return to sport does not equate to a poor clinical outcome, as patients can still experience statistically significant and clinically meaningful improvements in patient-reported outcome measures. [40] (10.1016/j.arthro.2022.01.015)
- [L4] There is a need for consistent and transparent reporting of outcomes when treating complex cases. [41] (10.1016/j.arth.2025.10.031)
- [L3] Prognostic subgrouping revealed more diverse patterns in pain and function recovery over 1 year than observed in the same patients classified by traditional diagnostic groups and may better reflect the diversity in recovery of common MSK disorders. [42] (10.1186/s12891-021-04332-3)
- [L3] This validation study supports that the classification system and treatment algorithm for surgical treatment of various GTPS types leads to favorable patient-reported outcomes. [43] (10.1016/j.arthro.2021.01.058)
- [L2] There has been a demonstrated increase in core outcome sets developed for both research and routine practice, and consistently high inclusion of patient participants. [44] (10.1371/journal.pone.0244878)
- [L4] Patients with GCT should be followed indefinitely, and referred promptly if new symptoms, particularly pain, emerge. [45] (10.1302/0301-620x.104b12.bjj-2022-0401.r1)
- [L5] Outcome evaluation is a systematic and objective procedure to determine the impact and success of a therapeutic program, focusing on the patient's well-being in daily life. [46] (10.1016/j.otsr.2013.06.012)
- [L3] Several countries' DRG system might be improved through the introduction of classification variables for revision of knee replacement or for the presence of complications or comorbidities. [47] (10.1007/s00167-013-2374-6)
- [L1] The effectiveness for pain and disability was sustained over 2 years, but the objective measure of walking ability improved in both groups, with no statistical difference between operative and nonoperative groups. [48] (10.2106/jbjs.8908.ebo2)
- [L3] Oxford UKA of the medial compartment ensures good long-term survivorship with an excellent functional outcome. [49] (10.1007/s00167-018-5299-2)
- [L5] Understanding what constitutes a real-world benefit from treatment is key to designing and critically appraising clinical research. [50] (10.1177/1753193419870100)
- [L3] Between 1- and 2-year follow-up assessments, 21.5% of patients improved and 18.6% declined in self-reported functional status. [51] (10.1177/03635465221122769)
- [L2] Further research is necessary to clarify the effects on patient outcomes of using PROs in clinical practice. [52] (10.1186/s12891-019-2620-2)
- [L4] However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time. [53] (10.1007/s00167-010-1042-3)
- [L2] Findings point to a lack in robustness for conclusions drawn from RCTs relating to nonoperative treatment for lateral epicondylitis, where a reversal of only 3 patient outcomes could considerably influence reported statistically significant findings. [54] (10.1016/j.xrrt.2025.03.008)
- [L3] Alternative glenoid classification systems or predictive models should be considered to provide more precise prognoses. [59] (10.1016/j.jse.2023.08.029)
- [L3] The short term clinical outcomes of patients undergoing revision rotator cuff repair were similar to primary rotator cuff repair. [60] (10.1177/2325967114s00016)
- [L3] The MRI-based BOGIE score appears to correlate with early clinical function and may be useful as an adjunct tool in decision making on activity progression. [61] (10.1177/0363546520902475)
- [L3] Functional ability and health related quality of life improved after rehabilitation. [62] (10.1186/1471-2474-14-57)
- [L3] Non-responders had significantly increased mortality and significantly worse baseline scores despite similar demographics and revision risk. [63] (10.1302/0301-620x.108b1.bjj-2025-0683.r1)
- [L3] Compared with CTA patients, RA patients achieved similar clinical outcomes following RSA. [64] (10.1016/j.jse.2020.05.022)
- [L4] For patients experiencing pain or limited range of motion, ongoing assessment using additional X-rays, computed tomography scans, or other diagnostic tests is recommended for effective monitoring. [65] (10.1016/j.jse.2024.11.010)
- [L4] Epidemiology and non-epidemiology-trained reviewers can apply the levels-of-evidence guide to published studies with acceptable interobserver agreement, though the validity of this system remains a question for future research. [66] (10.2106/00004623-200408000-00016)
- [L2] Different FEDS categories showed varying degrees of improvement and failure rates, indicating that the system can be used to provide prognostic insight for presurgical education. [67] (10.1016/j.jse.2019.12.002)
- [L4] In the recovered and unrecovered groups, improvement of tendinopathy area was 60% versus 16%, indicating that postoperative MRI findings reflect clinical outcomes. [68] (10.1016/j.arthro.2022.07.019)
- [L3] Non-union is associated with poor clinical outcomes. [69] (10.1177/17585732221131923)
- [L4] Patients failing conservative treatment report good outcomes following surgical treatment of trapezius palsy. [70] (10.1177/1758573219872730)
- [L4] To compare clinical outcomes between different modalities, we should consider not only statistically significant differences but also the MCID. [71] (10.1016/j.jse.2017.10.032)
- [L1] Operative treatment resulted in greater improvement in Constant scores and significantly decreased pain scores compared to nonoperative management. [72] (10.1016/j.jse.2017.09.032)
- [L4] The Musculoskeletal Outcomes Data Evaluation and Management System achieved its goal regarding the development of validated questionnaires, but the data collection component did not. [73] (10.1097/01.blo.0000137589.23853.61)
- [L1] The first requirement to make progress in this field is to agree on unambiguous terminology and classification of UEDs. [74] (10.1186/1471-2474-7-7)
- [L5] Comprehensive registries collecting information on orthopaedic injuries, treatment, complications, and outcomes are required to characterize trauma, evaluate treatment options, and improve care and outcomes. [76] (10.1016/j.injury.2005.02.027)
- [L2] Nonoperative management of FAI syndrome is effective in a majority of adolescent patients, with significant improvements in PROs persisting at a mean 5-year follow-up. [77] (10.1177/03635465211030512)
- [L4] No evidence exists on outcomes following non-operative management of FAI with concomitant Tönnis Grade 2 or more OA of the hip. [78] (10.1007/s00167-022-07274-y)
- [L3] IM and EM guides provided comparable radiographic and clinical outcomes, allowing flexible selection based on patient anatomy and surgical conditions. [79] (10.1186/s12891-025-09390-5)
- [L4] A reliable 6-stage MRI-based classification addressing UCL tear grade and location may confer decision making between operative and nonoperative management. [81] (10.1016/j.jse.2018.11.063)
- [L3] Non-operative treatment of partial ACL rupture is justified as it yields good results in the majority of patients, though a substantial number will aggravate their injury over time. [82] (10.1007/s001670050015)
- [L4] Elbow ROM is influenced by age, sex and BMI. [83] (10.1177/1758573217728711)
- [L1] Radiographic osteoarthritis was correlated with higher failure rates, increased conversion to total hip arthroplasty, and worse outcomes after surgical management of femoroacetabular impingement. [84] (10.5435/jaaos-d-17-00380)
- [L4] Radiographic predictors for failure were related to over- and undertreatment of acetabular rim trimming. [85] (10.1007/s11999-014-4025-8)
- [L4] The most common mechanism appears to involve a valgus moment to an extended elbow, suggesting some acute elbow dislocations may result from acute valgus instability and are distinct in nature and mechanism from posterolateral rotatory instability. [86] (10.1016/j.jhsa.2012.12.017)
- [L3] The overall midterm risk of revision after RSA for CTA was low (5%). [87] (10.1016/j.jse.2018.02.060)
- [L4] The overall decrease in ACL tears, ACLR, and nonoperative management found in this study is a reversal from trends reported in the literature from previous decades. [88] (10.1016/j.arthro.2024.08.018)
- [L4] Correlation of retrieval findings with radiographic and clinical data may help establish predictors of prostheses at risk for failure. [89] (10.1016/j.jse.2015.06.004)
- [L5] Pitching 100 balls induces a significant reduction in dynamic stabilizing ability against elbow valgus laxity. [90] (10.1016/j.jse.2023.11.001)
- [L4] Large standard deviations of normative values in combination with different measurement devices used, as well as the different measurement positions of the subjects, demonstrated that there is no consensus about measuring the isometric elbow strength and therefore the normative values have to be interpreted with caution. [91] (10.1177/1758573217748643)
- [Case_report] This appears to be a reasonable method to salvage this difficult and challenging problem when nonsurgical management has failed to provide relief. [92] (10.1016/j.jse.2011.08.043)
- [L2] Patients undergoing shoulder surgery with a history of a cervical spine condition have increased rates of surgical complications and mixed but consistently nonsuperior patient-reported outcomes compared to patients without dual shoulder-cervical spine pathology. [93] (10.1016/j.arthro.2025.01.010)
- [L4] Pain originating from LHBT induced an approximately 30% decrease of shoulder abduction and elbow flexion strength despite there being no structural or biomechanical abnormalities in this model. [95] (10.1016/j.jse.2018.05.009)
- [L4] The study observed a low complication rate and good early clinical outcomes, indicating that this approach can be considered for broader use in the future. [96] (10.5397/cise.2024.00836)
- [L3] History of prior implant complication was the most important patient feature for XGBoost performance, a novel patient feature that surgeons should consider when counseling patients. [98] (10.1177/24715492221075444)
- [L3] Despite design advances, complication rates remain high. [99] (10.1302/0301-620x.96b10.33815)
- [L4] Postoperative complication rates were similar to those found in prior studies, although the true rate of rerupture may be higher than previously thought. [103] (10.1016/j.jse.2015.11.012)
- [L3] Major complications occurred at roughly half the rate in the staged group, suggesting a potential safety advantage, although the study was underpowered for complication analysis. [104] (10.1016/j.jhsa.2025.10.019)
- [L3] Experience did not lead us to operate on younger patients, but significantly modified patient selection, results, and complications. [106] (10.1016/j.jse.2011.11.010)
- [L5] Longitudinal studies require continued contact and evaluation of patients for many years after the administration of treatment, and every reasonable effort should be made to obtain information on all patients in a study to ensure meaningful data. [111] (10.2106/00004623-199803000-00018)
- [L1] Early reimplation (abbreviated two-stage) provides similar outcomes to traditional two-stage exchange, though optimal timing and selection criteria remain undefined. [112] (10.1016/j.arth.2025.10.075)
- [L4] Patients with a preoperative duration of symptomatic medial knee overload/arthritis of two years or greater do not experience inferior PRO or clinical outcomes than patients with a symptom duration of less than 2 years at mid-term follow-up. [113] (10.1016/j.jisako.2022.03.003)
- [L5] Despite marked improvements in survival during the past 40 years for patients with localized disease, lesser improvements have been seen in patients with metastatic or recurrent disease. [115] (10.5435/00124635-201002000-00004)
- [L1] The two designs functioned equivalently at the time of early follow-up in this low-to-moderate-demand patient group. [116] (10.2106/jbjs.j.00157)
See Also¶
- Osteochondritis Dissecans of the Capitellum
- Patient Outcomes
- Elbow Arthroplasty
- Cubital Tunnel Syndrome
References¶
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